Objective:To explore the effect of informatization three-level linkage health management in stroke patients.Methods:From January 2019 to January 2021, convenience sampling was used to select 136 stroke patients admitted to Lishui Hospital of Traditional Chinese Medicine as the research object. According to the random number table method, the patients were divided into the observation group and the control group, with 68 cases in each group. The observation group was given informatization three-level linkage health management, and the control group received traditional three-level linkage health management, and the intervention period was 6 months. The scores of Self-Management Behavior Scale of Stroke (SMBSS) , Barthel Index, Family Adaptation Partnership Growth Affection and Resolve (APGAR) and stroke recurrence were compared between the two groups before and after the intervention.Results:Among the 136 patients, the intervention was terminated in three cases due to disease progression, in two cases due to other reasons, and in three cases due to the invalidity of the questionnaire, resulting in no reference significance to the research data. In the end, 65 patients were included in the observation group and 63 patients in the control group. After 6 months of intervention, the SMBSS, Barthel index and APGAR scores of the observation group were higher than those of the control group, and the differences were statistically significant ( P<0.05) . There was no statistical difference in the recurrence of stroke between the two groups ( P>0.05) . Conclusions:The informatization three-level linkage health management can improve the self-management ability, daily life ability and family intimacy of stroke patients.