Objective: To itvestigate the effect of Antidepressant on refractory irritable bowel syndrome(IBS).Methods: A self-control study of subclincal dosage of antidepressants therapy(fluoxetine 10mg/d or paroxetine 10mg/d) for 12 weeks in 46 patients with refractory IBS was performed.The clinical outcomes were evaluated by indexs of symptom severity and symptom frequency and the score of Hamiton depession scale(HAMD) and Hamiton anxiety(HAMA).Results: All 46 cases completed the therapy.After the course of treatment,indexes of symptom severity and symptom frequency and the scores of HAMD and HAMA were significantly lower than those before treatment(P

Objective To discuss the value of network with real-time monitoring case in hospital. Methods Using the real time monitoring case of "No.1 Military Medical Project" and examining, analysis and evaluating. Results The quality of case and medical care were advanced obviously. Conclusion The scientification and standardization of case realized is propitious for hospital management.

Objective: To explore the express of type A behavior in families with and without history of hypertension Method: 178 members of 40 families with history of hypertension and 27 families without completed type A behavior questionnaire Result: Type A behavior was not associated with hypertension 35 2% children of both parents with type A was type A, 34 4% children of both parents with type B was type B Children of one parent with type A were more commonly manifested as type B Conclusion: Type A behavior has no association with hypertension Behavior pattern itself has family constellation

0.05),but the rate of recurrent bleeding in EBL group was significantly lower than that in EIS group (6.3% vs. ~40.0% , P0.05). Conclusions EBL is an effective and safe ~endoscopic treatment for hemorrhagic Dieulafoy's lesion.

Objective To observe the expression and distribution of IL 10 in local vessel after balloon injury in rat and study its significance in the response of artery injury Methods RT PCR and Western Blot as well as immunohistochemical method were used to assay the changes of IL 10′s mRNA as well as expression and distribution of protein Results There is no expression of IL 10 in vascular wall of normal rat After Balloon injury, the level of IL 10 mRNA and product of IL 10 was up regulated, and immunohistochemiscal staining showed immunoreactive IL 10 mainly in smooth muscle cells Conclusion IL 10 is expressed in balloon injured aorta and may contribute to the modulation of the local inflammatory response

Adult ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Mouth Mucosa ; drug effects ; Phytotherapy ; Recurrence ; Stomatitis, Aphthous ; drug therapy

Non-motor symptoms are important components of the manifestations of Parkinson's disease, usually including neuropsychotic symptoms, sleep disorder, autonomic dysfunction, feels obstacle, and so on. This paper reviewed the manifestation, relevant factors,pathogenesis and treatment of non-motor symptoms of Parkinson's disease.

Objective:To investigate the expression and clinical significance of effector T cell (Teff), regulatory T cell (Treg) and their cytokines in patients with vitiligo.Methods:84 patients with vitiligo (38 cases in stable stage, 46 cases in advanced stage) who were admitted to the Dermatology Department of the Dezhou People's Hospital between June 2018 and June 2019 and 30 healthy people (control group) were enrolled in the study. The levels of Teff subsets and Treg cells in peripheral blood were detected by flow cytometry. The levels of Teff subsets and Treg cells-associated cytokines were detected by enzyme-linked immunosorbent assay (ELISA). The relationship between Teff subsets and Treg cells levels in peripheral blood, relationship between Teff subgroups, Treg cells-associated cytokines and course of vitiligo, skin lesion area were analyzed.Results:The levels of T helper cell (Th)17 and Th22 in peripheral blood of vitiligo group were significantly higher than those of control group, while levels of Treg cells were significantly lower than control group ( P<0.05). Compared with the stable vitiligo group, the levels of Th17 and Th22 in peripheral blood were higher and levels of Treg cells were lower in the advanced vitiligo group ( P<0.05). Treg cell level was negatively correlated with Th17 cell level ( r=-0.303, P=0.001), and negatively correlated with Th22 cell level ( r=-0.200, P=0.033). The levels of serum interleukin (IL)-17 and IL-22 in vitiligo group were significantly higher than those in control group, while the level of transforming growth factor-β (TGF-β) was significantly lower than that in control group ( P<0.05). Compared with the stable vitiligo group, levels of serum IL-17 and IL-22 were higher and level of TGF-β was lower in the advanced vitiligo group ( P<0.05). Correlation analysis showed that levels of IL-17 and IL-22 were positively correlated with skin lesion area ( r=0.361, 0.288, P<0.05), and level of TGF-β was negatively correlated with skin lesion area ( r=-0.312, P<0.05). Conclusions:Teff/Treg cells are unbalanced in patients with vitiligo, showing obvious shift to Teff subsets. The progression of vitiligo may be related to Teff subsets and Treg cells-associated cytokines.

0.05), but the rate in eradicating varices after the first treatment session was significantly higher(66.7% vs. 10.0%, P 0.05); the comparison of the Kaplan Meier estimate of survival did not show any statistically significant differences in the two groups. Conclusions The sandwich method leads to longer retention of sclerosant in varices and is far superior to EVL alone with respect to the rate in eradicating varices after the first treatment session and prevention of rebleeding and variceal recurrence. The study shows the sandwich method is the optimal endoscopic method for the treatment of EVB.

Objective: To establish the determination method for osthole in Cnidii and Fuyan ling Capsule(Fructus Cnidii, Radix Sophorae Flavescentis, Herba Agrimoniae, Radix Stemmonae, etc.). Methods: RP HPLC was used with Alltima C 18 column (250mm?4.6mm,5?m), detection wavelength at 322nm, mobile phrase: methanol water (75∶25), flow rate: 1mL?min -1 . Results: Regression equation of Fuyanling capsules is Y =22957x-816, and r=0.9999 with repetition rate RSD 1.45%. Conclusion: This method is simple, easy and reliable.