The results of study showed no significant differences on the stability of eye drop preparation containing vitamin B5 kept in neutral glass bottle and in PE vial. Light and high temperature make impact on the stability of the preparation so it needs to be kept from light in a cool place. With selected formula, the eye drop containing vitamin B5 kept in PE vial has stability at least 12 months at room conditions
Ophthalmic Solutions ; Pantothenic Acid

Experimental studies were carried out concerning the disintegration of 10 preparation of tablet, capsules with various group of medicinal products, produced and distributed by the Pharmaceutical Enterprise X including tablets of paracetamol, tablet of indomethacine, tablet of isoniazid, tablet of metronidazol, tablet of quinin sulfate, tablet of papaverin hydrochloride, tablet of theophylin and tablet of chloroquin phosphate. Results showed that 9 preparations (90%) satisfied the criterions of disintegration
Pharmaceutical Preparations ; Adjuvants, Pharmaceutic ; Capsules ; drugs ; tablets

Drug's quality on the market must conform to standards of manufacturer based on Vietnamese Pharmacopoeia III. This report deals with standard about dissolubility of some antibiotic pill products of Pharmaceutical Factory X circulating on the market, such as amoxiciline, penicilline, cloramphenicol, ciprifloxacine, .... (10 types) by Dissolution test method, showed that there were 9 products (90%) attained standards Vietnamese Pharmacopoeia III. This is a impressed result of Vietnamese Pharmaceutical Industry in enhancing drug's quality
Solubility ; Antibiotics, Antifungal ; Quality Control

The effect of buffer system, adjustment substance pH, pH of solution, antioxygen and antiseptic on the stability of eye drop solution with vitamin B5 was studied. The result: at pH 5,5, buffer system of acetat, of citrat and of phosphat strictly influence to the stability of eye drop solution containing vitamin B5. This solution also sustained with antioxygen dinatri edetat 0,02%, combining with natri metabisulfid 0,1% -0,3% don’t make increase the stability of product. The antiseptic of benzalkonium clorid and chlorobutanol don’t influence to the stability of this solution. But benzalkonium clorid is appropriate than chlorobutanol because of it don’t absorb through PE plastic, the antiseptic efficacy increase with the presence of dinatri edetat and this make increase the bioavailability of drug
Ophthalmic Solutions ; Pantothenic Acid ; Pharmaceutical Preparations

This paper introduced some solution for strengthening the quality of domestic drug, the factors for guaranteeing comprehensive management of drug quality, a model of organization system, comprehensive practical system in drug manufacture and supply. And the methods of the quality of domestic drug.
Pharmaceutical Preparations ; Quality Control

Although development of the information technology, computerization, automation, industrial robots and modernization of equipments, the consideration and enhancement of the human resource always play an most important role for the company's success and development. This paper presented some problems of the human resource of the drugs quality assurance network in the pharmaceutical companies and introduced some solutions for this aspects
Pharmaceutical Preparations ; Public Sector ; Private Sector

This paper introduced the drug quality guarantee and quality guarantee system; Situation of drug quality guarantee system in drug manufacturing enterprise of Vietnam. Orientation and building of quality guarantee system in drug manufacturing enterprise
Pharmaceutical Preparations ; Quality Control ; Public Sector ; Private Sector

Pharmaceuticals industry is developing over the country. In a new tendency, pharmaceutical enterprises have trained staff and workers to meet new requirements as well as invested in infrastructure and modern equipment. These enterprises have registered to produce 7,569 medical completed products including 4,000 new medications which are resulted from 401 active ingredients. Revenues in 2004 reached 4,700 billion VND. However, Vietnam’s pharmaceutical industry is still limited and Vietnam ranks in forth group in world's pharmaceutical industry. Restrictions of Vietnam’s pharmaceutical industry are presented in two factors: pharmaceutical chemistry industry and pharmaceutical biological industry. In global’s competitive market with many unprecedented changes, Vietnamese enterprises in general and pharmaceutical enterprises in particular have a few competition advantages. Therefore, competition advantages should be created in the market. Factors of human resources and science – technology is very important, which is key foundation and motivation to help the pharmaceutical enterprises stablize and develop in current integration tendency
Pharmaceutical Preparations ; Industry

Establishing the formulation of 0.1% diclofenac eye drops by making up solution and quantitative by High- Performance Liquid Chromatography (HPLC). Results: Natri diclofenac eye drop 0.1% mixing with phosphate buffer 0.05M get the most stability at pH=7.5. The percentage of propylene glycol and natrimetabisulfit in the formulation influenced significantly the stability of eye drop solution. The stability increased gradually if the rates of natri metabisulfit antioxygen are 0.1%; 0.2% and 0.3% or there was an increase of propylene glycol with the rate of 0%, 5% and 10%. This preparation is stable at least 5 months at temperature 50oC and protected from light. This preparation may be stable more than 20 months at room conditions 30oC and protected from light
Ophthalmic Solutions ; Diclofenac

The factors selected as an independent variable to study included antioxidant dinatri EDTA and viscosity enhancers PVP. Value of pH and percent of remained tobramycine contents after 3 months with ageing at 500C compared with primary tobramycine were selected as a dependent variable. Experimental model was designed according to model of quadratic equation including 9 formulas. The relationship between independent variables X and dependent variables Y conformed to quadratic regressive equation. Base on preliminary formulas selected, Modde 5.0 software was used to trace experimentally and deal with the results. Optimal formula of tobramycine eye drop 0.3% had stableness over 3 months at 50oC and over 12 months at normal condition
Ophthalmic Solutions ; Tobramycin