1.Primary Aldosteronism and Cerebrovascular Diseases.
Zheng Wei CHEN ; Chi Sheng HUNG ; Vin Cent WU ; Yen Hung LIN
Endocrinology and Metabolism 2018;33(4):429-434
As diagnostic techniques have advanced, primary aldosteronism (PA) has emerged as the most common cause of secondary hypertension. The excess of aldosterone caused by PA resulted in not only cardiovascular complications, including coronary artery disease, myocardial infarction, arrhythmia, and heart failure, but also cerebrovascular complications, such as stroke and transient ischemic attack. Moreover, PA is associated more closely with these conditions than is essential hypertension. In this review, we present up-to-date findings on the association between PA and cerebrovascular diseases.
Aldosterone
;
Arrhythmias, Cardiac
;
Cerebrovascular Disorders*
;
Coronary Artery Disease
;
Heart Failure
;
Hyperaldosteronism*
;
Hypertension
;
Ischemic Attack, Transient
;
Myocardial Infarction
;
Stroke
4.Restoring blood flow to the lateral plantar artery after elevation of an instep flap or medialis pedis flap
Jonathan VELAZQUEZ-MUJICA ; Francesco AMENDOLA ; Davide SPADONI ; Hung-Chi CHEN
Archives of Plastic Surgery 2022;49(1):80-85
The instep flap and medialis pedis flap are both originate based on the medial plantar artery. The medialis pedis flap is based from the deep branch and the instep flap is based from the superficial branch. To increase the axial rotation, it is acceptable to ligate the lateral plantar artery. However, this can partially affect the blood supply of the plantar metatarsal arch. We restored the blood flow with a vein graft between the posterior tibial artery and the ligated stump. From 2012 to 2020, 12 cases of heel reconstruction, including seven instep flaps and five medialis pedis flaps, were performed with ligation of the lateral plantar artery. The stump of the lateral plantar artery was restored with a vein graft and between the posterior tibial artery and the ligated stump. Patients were followed for 18 months. Long-term results showed the vascular restoration of the lateral plantar artery remained patent demonstrated by doppler ultrasonography. Restoring blood flow to the lateral plantar artery maintains good blood supply to the toes. If the patient in the future develops a chronic degenerative disease, with microvascular complications, bypass surgery can still be performed because of the patency of both branches.
5.The Risk of Cellulitis in Cirrhotic Patients: A Nationwide Population-Based Study in Taiwan.
Ming Nan LIN ; Chen Chi TSAI ; Tsung Hsing HUNG ; Chih Chun TSAI
Gut and Liver 2012;6(4):482-485
BACKGROUND/AIMS: Cellulitis is a common infectious disease. However, the risk of cellulitis in cirrhotic patients is not well established, and whether liver cirrhosis is a risk factor for cellulitis remains unknown. This study evaluated the relationship between cellulitis and liver cirrhosis. METHODS: The National Health Insurance Database, which was derived from the Taiwan National Health Insurance program, was used to identify patients. The study group consisted of 39,966 patients with liver cirrhosis, and the comparison group consisted of 39,701 randomly selected age- and sex-matched patients. RESULTS: During the 3-year follow-up period, 2,674 (6.7%) patients with liver cirrhosis developed cellulitis, and 1,587 (4.0%) patients without liver cirrhosis developed cellulitis (p<0.001). Following a Cox's regression analysis adjusted for age, sex, and underlying medical disorders, the cirrhotic patients demonstrated a greater risk for the occurrence of cellulitis than the non-cirrhotic patients during the 3-year period (hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.55 to 1.77; p<0.001). Additionally, cirrhotic patients with complications also had a greater risk for the occurrence of cellulitis than those patients without complications (HR, 1.23; 95% CI, 1.14 to 1.33; p<0.001). CONCLUSIONS: We conclude that cirrhotic patients have a greater risk of cellulitis than non-cirrhotic patients.
Cellulitis
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Communicable Diseases
;
Follow-Up Studies
;
Humans
;
Liver
;
Liver Cirrhosis
;
National Health Programs
;
Risk Factors
;
Taiwan
6.The Effect of the First Spontaneous Bacterial Peritonitis Event on the Mortality of Cirrhotic Patients with Ascites: A Nationwide Population-Based Study in Taiwan.
Tsung Hsing HUNG ; Chen Chi TSAI ; Yu Hsi HSIEH ; Chih Chun TSAI ; Chih Wei TSENG ; Kuo Chih TSENG
Gut and Liver 2016;10(5):803-807
BACKGROUND/AIMS: Spontaneous bacterial peritonitis (SBP) contributes to poorer short-term mortality in cirrhotic patients with ascites. However, it is unknown how long the effect of the first SBP event persists in these patients. METHODS: The National Health Insurance Database, derived from the Taiwan National Health Insurance Program, was used to identify and enroll 7,892 cirrhotic patients with ascites who were hospitalized between January 1 and December 31, 2007. All patients were free from episodes of SBP from 1996 to 2006. RESULTS: The study included 1,176 patients with SBP. The overall 30-day, 90-day, 1-year, and 3-year mortality rates in this group were 21.8%, 38.9%, 57.5%, and 73.4%, respectively. The overall 30-day, 90-day, 1-year, and 3-year mortality rates in the non-SBP group were 15.7%, 32.5%, 53.3%, and 72.5%, respectively. After adjusting for gender, age, and other medical comorbidities, the adjusted hazard ratios of SBP for 30-day, 30- to 90-day, 90-day to 1-year, and 1- to 3-year mortality were 1.49 (95% confidence interval [CI], 1.30 to 1.71), 1.19 (95% CI, 1.02 to 1.38), 1.04 (95% CI, 0.90 to 1.20), and 0.90 (95% CI, 0.77 to 1.05), respectively, compared with the non-SBP group. CONCLUSIONS: The effect of SBP on the mortality of cirrhotic patients with ascites disappeared in those surviving more than 90 days after the first SBP event.
Ascites*
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Comorbidity
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Fibrosis
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Humans
;
Mortality*
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National Health Programs
;
Peritonitis*
;
Taiwan*
7.Multi-Detector Row Computed Tomographic Evaluation of a Rare Type of Complete Vascular Ring: Double Aortic Arch with Atretic Left Arch Distal to the Origin of Left Subclavian Artery.
Ying Ying HUNG ; Yun Ching FU ; Hao Ji WEI ; I Chen TSAI ; Clayton Chi Chang CHEN
Korean Journal of Radiology 2013;14(5):845-848
Double aortic arch with an atretic left arch distal to the origin of left subclavian artery was diagnosed with multi-detector row computed tomography (MDCT) in two children with dysphagia. This rare type of complete vascular ring is clinically important because it may be confused with right aortic arch in mirror imaging. Anatomic details of this rare type of complete vascular ring demonstrated on MDCT facilitated appropriate surgical treatment.
Adolescent
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Aorta, Thoracic/*abnormalities/radiography/surgery
;
Child, Preschool
;
Deglutition Disorders/etiology/radiography/surgery
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Female
;
Humans
;
Multidetector Computed Tomography/*methods
;
Subclavian Artery/*abnormalities/radiography/surgery
;
Vascular Malformations/complications/*radiography/surgery
;
Vascular Surgical Procedures
8.Apoptotic effect of cisplatin and cordycepin on OC3 human oral cancer cells.
Ying-hui CHEN ; Lyh-Jyh HAO ; Chih-peng HUNG ; Jung-wei CHEN ; Sew-fen LEU ; Bu-miin HUANG
Chinese journal of integrative medicine 2014;20(8):624-632
OBJECTIVETo evaluate apoptotic effects of cisplatin and cordycepin as single agent or in combination with cytotoxicity in oral cancer cells.
METHODSThe influences of cisplatin (2.5 μg/mL) and/or cordycepin treatment (10 or 100 μmol/L) to human OC3 oral cancer cell line were investigated by morphological observation for cell death appearance, methylthiazoletetrazolium (MTT) assay for cell viability, flow cytometry assay for cell apoptosis, and Western blotting for apoptotic protein expressions.
RESULTSData demonstrated that co-administration of cisplatin (2.5 μg/mL) and cordycepin (10 or 100 μmol/L) resulted in the enhancement of OC3 cell apoptosis compared to cisplatin or cordycepin alone treatment (24 h), respectively (P <0.05). In flow cytometry assay, percentage of cells arrested at subG1 phase with co-treatment of cordycepin and cisplatin (30%) was significantly higher than cisplatin (5%) or cordycepin (12%) alone group (P <0.05), confirming a synergistically apoptotic effect of cordycepin and cisplatin. In cellular mechanism study, co-treatment of cordycepin and cisplatin induced more stress-activated protein kinase/Jun terminal kinase (JNK), the expressions of caspase-7, and the cleavage of poly ADP-ribose polymerase (PARP) as compared to cisplatin or cordycepin alone treatment (P <0.05).
CONCLUSIONCisplatin and cordycepin possess synergistically apoptotic effect through the activation of JNK/caspase-7/PARP pathway in human OC3 oral cancer cell line.
Apoptosis ; drug effects ; Caspase 7 ; metabolism ; Cell Count ; Cell Line, Tumor ; Cell Shape ; drug effects ; Cell Survival ; drug effects ; Cisplatin ; pharmacology ; Deoxyadenosines ; pharmacology ; Drug Synergism ; G1 Phase ; drug effects ; Humans ; JNK Mitogen-Activated Protein Kinases ; metabolism ; Mouth Neoplasms ; pathology ; Phosphorylation ; drug effects ; Poly(ADP-ribose) Polymerases ; metabolism
9.Harm Avoidance is Correlated with the Reward System in Adult Patients with Attention Deficit Hyperactivity Disorder: A Functional Magnetic Resonance Imaging Study
Tsung-Hua LU ; Shih-Hsien LIN ; Mei Hung CHI ; Ching-Lin CHU ; Dong-Yu YANG ; Wei Hung CHANG ; Po See CHEN ; Yen Kuang YANG
Clinical Psychopharmacology and Neuroscience 2023;21(1):99-107
Objective:
Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce.
Methods:
Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study.
Results:
Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed.
Conclusion
Understanding the roles of harm avoidance and brain activation during risk tasks is important.
10.Robotic Harvest of a Right Gastroepiploic Lymph Node Flap.
Pedro CIUDAD ; Shivprasad DATE ; Ming Hsien LEE ; Federico LO TORTO ; Fabio NICOLI ; Jun ARAKI ; Hung Chi CHEN
Archives of Plastic Surgery 2016;43(2):210-212
No abstract available.
Lymph Nodes*