1.Expression of HLA-DR antigen in different histologic types of gastric carcinoma.
Soo Sang SON ; Young Hun KIM ; In Ho KIM ; Eun Sook CHANG ; Sang Pyo KIM
Journal of the Korean Cancer Association 1993;25(6):818-825
No abstract available.
HLA-DR Antigens*
2.Anatomy as Elective Course for Fourth-Year Medical Students.
Tae Hwan KONG ; Sang Hun KIM ; Yong Hun SON ; Ki Sang CHUNG ; Ho Kyung JIN ; Hye Won JANG ; Chang Seok OH
Korean Journal of Physical Anthropology 2016;29(1):1-7
Five medical students in the fourth-year took anatomy as their elective courses for 1 month. They dissected one cadaver, and investigated Digital Report, under the course subjects as follows; (1) the shape of thyroid gland and the location of its isthmus, (2) the branches of left and right coronary arteries, (3) the number of blood vessels and bronchi on the hilum of lung, (4) topographical relationship of the renal vessels and ureter, and the shape of the renal pelvis, (5) the location and attachment of the appendix, (6) the penetration of median nerve through the pronator teres, (7) the sensory nerves and the extensor tendons on the dorsum of hand, (8) the branches of deep femoral artery. The pancreatic and live samples were processed and stained with H&E, for LM observation, since the individual had suffered from pancreatic cancer and got a Pylorus preserving pancreatico-duodenectomy (PPPD). At the last step of the elective course, students wrote small articles following the conventional method for writing manuscript. From the viewpoint of professor, the anatomy course for the fourth-year students were definitely different from that for first-year students, and had many positive effects in terms of anatomy education.
Appendix
;
Blood Vessels
;
Bronchi
;
Cadaver
;
Coronary Vessels
;
Education
;
Femoral Artery
;
Hand
;
Humans
;
Kidney Pelvis
;
Lung
;
Median Nerve
;
Pancreatic Neoplasms
;
Pylorus
;
Students, Medical*
;
Tendons
;
Thyroid Gland
;
Ureter
;
Writing
3.A case of myasthenia gravis associated with hypothyroidism.
Sang Jun BYEON ; Sang In LEE ; Se Sik CHOI ; Mu Hyun BAE ; Mi Hye JUNG ; Jong Hun KIM ; Sung Pyo SON ; Kap Do HUR
Journal of Korean Society of Endocrinology 1993;8(2):217-220
No abstract available.
Hypothyroidism*
;
Myasthenia Gravis*
4.The Effect of the Length of the Lingual Frenum and the Tongue Motion on Speech.
Seong Hee PARK ; Woo Sung SON ; Yong Deok KIM ; Sang Hun SHIN ; Uk Kyu KIM ; In Kyo CHUNG ; Soon Bok KWON
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2001;27(6):526-534
PURPOSE: The objective of this study is to ascertain whether the positive relationship exists among the frenum length, the tongue movement and the speech and to present the normal range of tongue movement and guidelines for the choice of surgery, observation if necessary. MATERIALS AND METHODS: 180 patients were evaluated. We divided 180 patients into 6 groups by age. Each group was separated as follows; the age of 2.5-4, 5-6, 7-9, 10-12, 13-15, 16-18. We measured the frenal length, the range of tongue motion and evaluated the speech so that we really questioned about the positive relationship between the tongue-tie and speech. We let the patient exercise the protrusive, both(right, left) laterotrusive, superior movement of the tongue. During these movements, we measured the distance between the vermilion border and the tongue tip. We also measured the distance from the tongue tip to the point contacting the upper lip with dorsum of the tongue during the maximal protrusive movement of the tongue. Three linear measurements of the anterior, inferior segment of the tongue, including the lingual frenum, are made. These measurements are as follows: 1. Distance A. Free anterior portion of the tongue from the point of frenular insertion to the tongue tip. 2. Distance B. The distance from the initiating point of the lingual frenum to the point connecting the two sublingual caruncles to the lingual frenum perpendicularly. 3. Distance C. The distance from the point contacting the line crossing the sublingual caruncles with the lingual frenum to the terminating point of the lingual frenum. We transform three linear measures into a statistical ratio, A/(A+B+C), representing the length of the free portion of the tongue compared with the total sublingual dimensions. In addition, we assessed the speech through Picture Consonant Articulation Test (PCAT) and tried to find out the relationship between the length of the lingual frenum and speech. CONCLUSION: As people are born, they have small and restricted tongue. As people grow old, tongue motions are more liberate, and unrestricted and they can speak so freely. Therefore we suggest that until age 5, oral and maxillofacial surgeons postpone the surgery if not urgent, evaluate the maximal lingual motions and PCAT according to this article and observe their changes.
Humans
;
Linear Energy Transfer
;
Lingual Frenum*
;
Lip
;
Reference Values
;
Tongue*
5.The Effect Of Lingual Frenectomy On The Tongue Motion And Speech.
Yong Deok KIM ; Sung Hee PARK ; In Gyo CHUNG ; Woo Sung SON ; Uk Kyu KIM ; Sang Hun SHIN
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2002;28(4):310-317
We have examined 20 tongue-tie patients who had been operated the lingual frenectomy in Department of Oral & Maxillofacial surgery, Pusan National University for the effect of the lingual frenectomy on the tongue motion and speech, and divided patients into groups by age. Each group was separated as follows ; the age of 5-6, 7-9, 10-12, 13-15, and 16-18. We measured the frenal lengh, the range of tongue motion and evaluated the speech pre- and postoperatively. The preoperative patient groups have larger tongue tips and smaller lingual frenums than normal ones. In the preoperative patient group, there was significant obstacle of the protrusive and superior movement of the tongue. The exception was the laterotrusive movement on both sides. There was the lower value of the Picture Consonant Articulation Test(PCAT) in the preoperative 5 to 6 yearold group compared with normal group. In other age groups, there was no significant difference. The range of postoperative PCAT in all age groups has become as similiar as that of normal group. The 5 to 6 year-old group which had significant difference in PCAT was improved in PCAT. In conclusion, we propose that the PCAT as well as anatomical tongue size and functional tongue movement is the basis of the indication of lingual frenectomy and the 5-6 year-old is the optimal time of the lingual frenectomy for improvement of the tongue movement and the speech.
Busan
;
Child
;
Humans
;
Lingual Frenum
;
Surgery, Oral
;
Tongue*
6.Association of Estrogen Receptor 2(ESR 2) Gene Polymorphisms with Ossification of the Posterior Longitudinal Ligament of the Spine.
Ki Tack KIM ; Sang Hun LEE ; Yoon Ho KWACK ; Eon Seok SON ; Kyoung Jun PARK ; Duk Hyun KIM
Journal of Korean Society of Spine Surgery 2012;19(1):1-7
STUDY DESIGN: Genetic screening of the estrogen receptor 2 (ESR2) genes in patients with ossification of the posterior longitudinal ligament (OPLL). OBJECTIVE: We studied the relationships between ESR2 gene polymorphisms and OPLL to understand the pathophysiology of OPLL. SUMMARY OF LITERATURE REVIEW: The OPLL has a strong genetic component. Several familial surveys and human leukocyte antigen (HLA) haplotype studies reveal that genetic background is an important component in the occurrence of OPLL and a large number of gene analysis studies were utilized to clarify the susceptible gene for OPLL, including COL11A2, BMP-2, TNF-alpha, NPPS, leptin receptor, transforming growth factor (TGF)-beta, Retinoic X receptor, ER, IL-1, PTH, and VDR have been performed. MATERIALS AND METHOD: Genomic deoxyribonucleic acid (DNA) samples obtained from 164 patients (93 men and 71 women) with OPLL and 219 control subjects, without the disease (105 men and 114 women) were amplified by polymerase chain reaction, and polymorphism genotypes were determined by the restriction endonuclease digestion. The distribution of genotypes was compared between the patients with the disease and the control subjects. RESULTS: The polymorphism of ESR2 [rs1256049, exon6, Val328Val, p=0.018, odd ratio (OR)=2.41, 95 confidence interval (CI)=1.15-5.02 in the recessive model] only showed statistically significant association between the control and the OPLL groups. The rest SNPs of ESR2 did not show any significant differences between the control and the OPLL groups. CONCLUSIONS: Estrogen receptor 2 (ESR2) gene polymorphisms (rs 1256049) was associated with OPLL. In future studies, we will perform target SNP chip between OPLL and candidate gene.
Digestion
;
DNA
;
DNA Restriction Enzymes
;
Estrogen Receptor beta
;
Estrogens
;
Genetic Testing
;
Genotype
;
Haplotypes
;
Humans
;
Interleukin-1
;
Leukocytes
;
Longitudinal Ligaments
;
Male
;
Ossification of Posterior Longitudinal Ligament
;
Polymerase Chain Reaction
;
Polymorphism, Single Nucleotide
;
Receptors, Leptin
;
Spine
;
Succinimides
;
Transforming Growth Factors
;
Tumor Necrosis Factor-alpha
7.Clinical Characteristics of Geriatric Patients Admitted to Yongin Hyoja Geriatric Hospital.
Yong Tae KWAK ; Il Woo HAN ; Don Soo KIM ; Sang Hun SEO ; Choong Soon LEE ; Seung Han SUK ; Il Hong SON
Journal of the Korean Neurological Association 2000;18(2):179-185
BACKGROUND: As the size of the elderly population has increased compared to the hole, there has been growing concern over potential health problems and geriatric hospitals for elderly people. However, despite the emerging needs for geriatric hospitals, there is no data on the clinical characteristics of patients being admitted to geriatric hospitals. To analyze the characteristics of elderly patients admitted to a geriatric hospital, we studied the medical records of patients admitted to Yong-in Hyoja Geriatric Hospital during a recent 20 months period. By clarifying the clinical characteristics of elderly patients admitted to a geriatric hospital, the basic data for understanding and treating elderly patients could be made. METHODS: We analyzed the medical records of 345 patients who were admitted to Yong-in Hyoja Geriatric Hospital from November 1997 to July 1999. The diagnosis of patients was largely subgrouped according to the existence of dementia, and subsequent detailed diagnoses were made. RESULTS: (1) The average age of patients was 74.59 years and there were slightly more females than males admitted (ratio, 1.15:1). (2) Most of the patients suffered from dementia (62.1%), of which vascular dementia was the most common(31.6%), followed by Alzheimer dementia(19.15%). (3) Compared to vascular dementia, patients with Alzheimer dementia had more severe cognitive dysfunction, psychosis, and agitation, while patients with vascular dementia had more problems in activities of daily living (ADL) and were more depressed than Alzheimer dementia (4) The average hospitalization duration was 3.54 months and incidence of significant illness after admission was 29.8%. The mortality rate was 10.9%. (5) The most common cause of death was infection (45.2%), followed by cardiovascular problems(16.2%). CONCLUSIONS: In addition to significant illnesses and mortality after admission, most patients admitted to geriatric hospitals have severe cognitive and behavioral problems. Therefore, adequate medical and neurological assessment and treatment for the aged is necessary.
Activities of Daily Living
;
Aged
;
Cause of Death
;
Dementia
;
Dementia, Vascular
;
Diagnosis
;
Dihydroergotamine
;
Female
;
Geriatrics
;
Gyeonggi-do*
;
Hospitalization
;
Humans
;
Incidence
;
Male
;
Medical Records
;
Mortality
;
Psychotic Disorders
8.A Case of Recurrent Nodular Fasciitis.
Myeung Hun CHOI ; Jiehyun JEON ; Sang Wook SON ; Hae Jun SONG ; Chil Hwan OH
Korean Journal of Dermatology 2006;44(12):1457-1459
Nodular fasciitis is a benign, reactive, myofibroblastic, proliferative process of unknown etiology. It presents as a solitary, painless, rapidly-growing nodule over several weeks' duration. The condition is self-limiting, and proper diagnosis is essential to avoid unnecessary aggressive treatment. Diagnosis is often a challenge because nodular fasciitis may be confused with a malignant tumor due to its aggressive clinical behavior and histological features. It is most commonly located on the extremities and then the trunk. Such lesions also usually occur in middle age and are rarely diagnosed in childhood. We report a case of recurrent nodular fasciitis that arose from subcutaneous tissue on the back of a pediatric patient.
Diagnosis
;
Extremities
;
Fasciitis*
;
Humans
;
Middle Aged
;
Myofibroblasts
;
Subcutaneous Tissue
9.Is It Real False Negative Finding in Motor Evoked Potential Monitoring during Corrective Surgery of Ankylosing Spondylitis? A Case Report.
Ki Tack KIM ; Sang Hun LEE ; Yoon Ho KWACK ; Eon Seok SON
Asian Spine Journal 2012;6(1):50-54
We performed L1 posterior vertebral columnar resection and posterior correction for Andersson's lesion and thoracolumbar kyphosis in an ankylosing spondylitis patient during motor evoked potential (MEP) monitoring. We checked MEP intra-operatively, whenever a dangerous procedure for neural elements was performed, and no abnormal findings were seen during surgery. After the operation, we examined neurologic function in the recovery room; the patient showed a progressive neurologic deficit and no response to MEP. After emergency neural exploration and decompression surgery, the neurologic deficit was recovered. We questioned whether to acknowledge the results of this case as a false negative. We think the possible reason for this result may be delayed development of paralysis. So, we recommend that MEP monitoring should be performed not only after important operative steps but also after all steps, including skin suturing, for final confirmation.
Decompression
;
Emergencies
;
Evoked Potentials, Motor
;
Humans
;
Kyphosis
;
Neurologic Manifestations
;
Paralysis
;
Skin
;
Spondylitis, Ankylosing
10.A Case of Extramammary Paget's Disease Treated with 5% Imiquimod Cream.
Myeung Hun CHOI ; Jie Hyun JEON ; Sang Wook SON ; Il Hwan KIM
Korean Journal of Dermatology 2006;44(3):365-368
Extramammary Paget's disease (EMPD) is a rare intraepidermal adenocarcinoma. Mohs micrographic surgery is considered the standard treatment. Other treatment modalities such as surgical excision, radiotherapy, topical chemotherapy, and photodynamic therapy are associated with varying degrees of effectiveness, and possible loss of tissue function and disease recurrence are seen. The search for an effective, safe treatment with minimal side effects proves to be challenging. Imiquimod is the first representative of a new class of immunomodulating drugs demonstrating potent antiviral and antitumor activity, and has been approved by the FDA for treating anogenital warts, actinic keratosis and basal cell carcinoma. Recent research has demonstrated its effective usage as a 5% cream in the management of EMPD. We report a case of EMPD of the scrotum successfully treated with topical 5% imiquimod cream. This has never been published in the Korea dermatologic literature.
Adenocarcinoma
;
Carcinoma, Basal Cell
;
Drug Therapy
;
Keratosis, Actinic
;
Korea
;
Mohs Surgery
;
Paget Disease, Extramammary*
;
Photochemotherapy
;
Radiotherapy
;
Recurrence
;
Scrotum
;
Warts