1.Extrahepatic Metastasis of Peripheral Cholangiocarcinoma: CT Findings.
Byoung Ho LEE ; Pyo Nyun KIM ; Soon Joo CHA ; Nam Suk LEE ; Churl Min PARK ; Se Hun KIM
Journal of the Korean Radiological Society 1994;31(4):715-718
PURPOSE: To evaluate the extrahepatic spread of peripheral cholangiocarcinoma with CT. MATERIALS AND METHODS: We retrospectively reviewed CT findings of extrahepatic spread in thirty-six patients with peripheral cholangiocarcinoma confirmed adenocarcinoma at surgery(n=5) or percutaneous biopsy(n--31) without primary leion in other organs, and analysed the frequency and distribution of enlarged lymph nodes, direct invasion of adjacent solid organs, and thrombosis of major vessels. RESULTS: Among the 36 cases, enlarged metastatic lymph node was noted in twenty-four(66.7%), direct invasion into adjacent organs in six(16.7%), portal and inferior vena caval thrombosis in five(13.9%). Enlarged lymph nodes were seen in hepatic nodes(n=16, 44.4%), portocaval nodes(n=15, 41.7%), interaortocaval nodes (n=10, 27.8) and celiac nodes in two(5.6%). Direct invasion was detected in the greater omentum(n=6), gallbladder(n:3) and stomach(n=2). Portal vein thrombosis(n:5) and thrombosis of inferior vena cava(n=2) were noted. CONCLUSION: Lymph node metastasis was seen in 67% in patients with peripheral cholangiocarcinoma. Direct invasion to adjacent organs and thrombosis in portal vein or inferior vena cava were occasionally associated.
Adenocarcinoma
;
Cholangiocarcinoma*
;
Humans
;
Lymph Nodes
;
Neoplasm Metastasis*
;
Portal Vein
;
Retrospective Studies
;
Thrombosis
;
Vena Cava, Inferior
2.Population pharmacokinetics and bayesian feedback method for nortriptyline dosage optimisation.
Sang Goo SHIN ; Jong Inn WOO ; In Jin JANG ; Chan Woong PARK ; Jae Jin KIM ; Jin Pyo HONG ; Kyeong Hun LEE
Journal of Korean Neuropsychiatric Association 1992;31(5):884-894
No abstract available.
Nortriptyline*
;
Pharmacokinetics*
3.Clinical Efficacy for 1% Zinc Pyrithione Shampoo for the Treatment of Dandruff.
Juhee PARK ; Beom Joon KIM ; Myeung Nam KIM ; Yeon Pyo HONG ; Jung Hun JU ; Jung Pyo LEE ; Kyung Hee SOHN ; Kui Lea PARK ; Eun Chang LEE ; Young Jin CHUN
Korean Journal of Dermatology 2009;47(8):875-883
BACKGROUND: Dandruff is a common complaint, and is suffered by up to 50% of the population at some time. Malassezia yeasts, which comprise part of the normal skin flora, might be a critical factor in this disease, as they have been found in higher proportions in patients with seborrheic dermatitis or dandruff, its milder form. OBJECTIVE: The aim of this study was to evaluate the clinical efficacy of 4 weeks of treatment with 1% zinc pyrithione (ZP) shampoo. METHODS: A randomized, double-blind, 4-week treatment period was preceded by a 1-week run-in period. A total of 30 patients were enrolled in this study. Assessments included the patient's subjective score (PSS) and the investigator's assessment score (IAS), images of the affected scalp area, the severity of sebum production, and the erythema and moisturizing effect of the shampoo. RESULTS: 1% ZP shampoo significantly reduced the extent and severity of scaling, as measured by folliscope imaging on visit 2 (p=0.0391) and visit 3 (p=0.0381), as well as pruritus related to the disease as measured by the grading systems, PSS (p=0.0352) and IAS (p=0.0142). Additionally, the results of this study show that a treatment regimen with 1% ZP shampoo significantly reduced scalp sebum production as measured by a sebumeter. Erythema measured by the chromameter was not as meaningful. The corneometric values were slightly increased in the group treated with 1% ZP shampoo but not in the group treated with ZP-free shampoo. Side effects of the ZP shampoo were quite mild and tolerable, and were observed only in a small group of patients. CONCLUSION: 1% ZP shampoo appears to be both effective and well-tolerated when used for the treatment of dandruff.
Dermatitis, Seborrheic
;
Erythema
;
Humans
;
Malassezia
;
Organometallic Compounds
;
Pruritus
;
Pyridines
;
Scalp
;
Sebum
;
Skin
;
Yeasts
;
Zinc
4.A Case of Early Gastric Cancer Associated with Small Cell Lung Cancer.
Mi Kyeong PARK ; Tae Hun KWON ; Jin Hong PARK ; Seol Young YUN ; Seong Ho CHOI ; Seong Pyo SON
Journal of the Korean Cancer Association 1998;30(2):414-420
The incidence of multiple primary cancers is low than that of single primary cancer. In gastric cancer, incidence of occurrence of multiple primary cancer is 3 to 11.3%. Because stomach and lung are unrelated organs, the combination of gastric cancer and lung cancer is rare. Its estimated incidence is about 10% of all multiple primary cancers. The histologic types of secondary lung cancer in one series, squamous cell carcinomas were 49%; adenocarcinomas were 28%; large cell carcinomas were 14%; small cell carcinomas were 9%; others were 6%. This patient had been diagnosed as early gastric cancer 3 years ago, but he refused operation for cancer and wasnt followed up. After 3 years, he revisited us for dry coughing and diagnosed as small cell lung cancer. At this time, previous gastric cancer was remained as well differentiated, early gastric adenocarcinoma. For its rarity, we report this case with review of literatures.
Adenocarcinoma
;
Carcinoma, Large Cell
;
Carcinoma, Small Cell
;
Carcinoma, Squamous Cell
;
Cough
;
Humans
;
Incidence
;
Lung
;
Lung Neoplasms
;
Small Cell Lung Carcinoma*
;
Stomach
;
Stomach Neoplasms*
5.Cone-beam computed tomography measurement of the position of the inferior alveolar nerve canal in mandibular prognathism.
Sung Hun YUN ; Ji Young PARK ; Young Kyung KO ; Je Uk PARK ; Sung Woon PYO
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2009;35(1):26-30
BACKGROUND AND OBJECTIVES: To determine the anatomic position of the inferior alveolar nerve (IAN) canal in patients with mandibular prognathism using the cone-beam CT (CBCT). MATERIALS AND METHODS: Fifty rami from 25 patients were evaluated. The images were taken by i-CAT and reconstructed 3-dimensionally using the Simplant 11 program. The linear distances between the IAN canal to the buccal cortex (a, a* and a**), from the IAN canal to the alveolar crest (b and b*) and the anterior margin (b**) and finally the buccal cortical thickness (c, c* and c**) were measured at three reference planes (VP, OP and HP). RESULTS: On the left side, the average distance of a, b and c were 7.12, 15.96 and 3.60 mm on the VP plane, respectively. On the OP, the distance of a*, b* and c* was 6.11, 8.83 and 2.63 mm. For the HP, the distance of a**, b** and c** was 4.84, 10.11 and 2.30 mm. On the right side, the distance of a, b and c, on the VP, was 7.10, 16.13 and 3.42 mm, respectively. On the OP, the distance of a*, b* and c* was 4.77, 8.75 and 2.68 mm. On the HP, the distance of a*, b* and c** was 4.55, 9.84 and 2.38 mm. Regarding the difference between genders, the distance in male's was longer than female's on the VP (p=0.019), and was thicker in males than females on the HP (p=0.002). CONCLUSION: The CBCT data provided accurate information about the location and course of the IAN.
Cone-Beam Computed Tomography
;
Female
;
Humans
;
Male
;
Mandibular Nerve
;
Prognathism
6.Cone-beam computed tomography measurement of the position of the inferior alveolar nerve canal in mandibular prognathism.
Sung Hun YUN ; Ji Young PARK ; Young Kyung KO ; Je Uk PARK ; Sung Woon PYO
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2009;35(1):26-30
BACKGROUND AND OBJECTIVES: To determine the anatomic position of the inferior alveolar nerve (IAN) canal in patients with mandibular prognathism using the cone-beam CT (CBCT). MATERIALS AND METHODS: Fifty rami from 25 patients were evaluated. The images were taken by i-CAT and reconstructed 3-dimensionally using the Simplant 11 program. The linear distances between the IAN canal to the buccal cortex (a, a* and a**), from the IAN canal to the alveolar crest (b and b*) and the anterior margin (b**) and finally the buccal cortical thickness (c, c* and c**) were measured at three reference planes (VP, OP and HP). RESULTS: On the left side, the average distance of a, b and c were 7.12, 15.96 and 3.60 mm on the VP plane, respectively. On the OP, the distance of a*, b* and c* was 6.11, 8.83 and 2.63 mm. For the HP, the distance of a**, b** and c** was 4.84, 10.11 and 2.30 mm. On the right side, the distance of a, b and c, on the VP, was 7.10, 16.13 and 3.42 mm, respectively. On the OP, the distance of a*, b* and c* was 4.77, 8.75 and 2.68 mm. On the HP, the distance of a*, b* and c** was 4.55, 9.84 and 2.38 mm. Regarding the difference between genders, the distance in male's was longer than female's on the VP (p=0.019), and was thicker in males than females on the HP (p=0.002). CONCLUSION: The CBCT data provided accurate information about the location and course of the IAN.
Cone-Beam Computed Tomography
;
Female
;
Humans
;
Male
;
Mandibular Nerve
;
Prognathism
7.Clinical Characteristics and Prognosis of Mild Head Injury in the Elderly559.
Yong Sook PARK ; Hun Joo KIM ; Kum WHANG ; Jin Soo PYEN ; Chul HU ; Soon Ki HONG ; Yong Pyo HAN
Journal of Korean Neurosurgical Society 2002;31(6):564-568
OBJECTIVE: The elderly population is rapidly growing, and the population over age 65 is expected to increase. To evaluate factors that determine recovery in this population, we report a clinical analysis of 77 elder patients of mild head trauma over 65 years of age. METHODS: The medical records were reviewed retrospectively for 77 head-injured patients aged 65 to 85 years who were admitted to our institution between March, 1995 and December, 1999. The outcome was compared with age, sex, Glasgow Coma Scale score, and radiologic characteristics. RESULTS: As in all age groups, males predominated and motor vehicle accidents accounted for a highest proportion(35%). Of the traffic accidents, pedestrian injuries were more common. The single most common lesion was subdural hematoma. The initial radiologic findings were not correlated with outcome. The GCS score was statistically correlated with prognosis. Sixty-one patients(79.2%) had favorable outcome. Ten of seventy-seven patients(13%) died whereas cerebral injury accounted for 5 deaths. Non-cerebral causes of death were composed of pneumonia, multi-organ failure and sepsis. The mean hospitalization was 52.3+/-12.6 days. CONCLUSION: The mortality rate after injury is higher in elderly patients. It is therefore the factors of intracranial and extracranial cause which influence survival and outcome be carefully treated. Neurologic deficits, even though mild, are the risk factor of poor prognosis in the elderly. Earlier identification of risk and aggressive support may be needed for decreasing the morbidity and the mortality in the elderly.
Accidents, Traffic
;
Aged
;
Cause of Death
;
Craniocerebral Trauma*
;
Glasgow Coma Scale
;
Head*
;
Hematoma, Subdural
;
Hospitalization
;
Humans
;
Male
;
Medical Records
;
Mortality
;
Motor Vehicles
;
Neurologic Manifestations
;
Pneumonia
;
Prognosis*
;
Retrospective Studies
;
Risk Factors
;
Sepsis
8.Pressor Responses to Intracerebroventricular Infusion of Hypertonic NaCl in Renal Hypertensive Rats.
Cheol Ho YEUM ; Chang Hyun PARK ; Jae Yeoul JUN ; Jai Hun KIM ; Jeong Hoe LIEE ; Soon Pyo HONG ; Pyung Jin YOON
Korean Circulation Journal 1999;29(2):216-221
BACKGROUND: The sodium concentration in the central nervous system may play an important role in cardiovascular function and body fluid regulation. The purpose of this investigation was to examine the effects of intracerebroventricular (ICV) infusion of hypertonic NaCl solutions on the cardiovascular responses in normotensive and 2-kidney, 1 clip (2K1C) renal hypertensive rats. METHODS: 2K1C hypertension was made by clipping the left renal artery and were used 4 weeks later. Age-matched control rats received a sham treatment. Under thiopental (50 mg/kg, IP) anesthesia, both isotonic and hypertonic NaCl solutions (0.15 M, 0.6 M and 1.2 M) were ICV applied, while blood pressure and heart rate (HR) responses were continuously monitored. RESULTS: Central administration of hypertonic NaCl solution caused an elevation in mean arterial pressure (MAP) and HR in both normotensive and 2K1C hypertensive rats. The response magnitude in the blood pressure was positively correlated to the NaCl concentration in normotensive rats, while the pressor responses to hypertonic NaCl were comparable regardless of the concentration of NaCl in hypertensive rats. Despite of the HR responses were similar in between two groups, the magnitude of the MAP increases were more elevated in hypertensive than in normotensive control rats. Isotonic NaCl solution, when centrally applied, caused an elevation in blood pressure only in hypertensive rats. CONCLUSION: These results indicate that the central sensitivity to sodium chloride is altered in 2K1C renal hypertensive rats.
Anesthesia
;
Animals
;
Arterial Pressure
;
Blood Pressure
;
Body Fluids
;
Central Nervous System
;
Heart Rate
;
Hypertension
;
Hypertension, Renal
;
Infusions, Intraventricular*
;
Placebos
;
Rats*
;
Renal Artery
;
Sodium
;
Sodium Chloride
;
Thiopental
9.On the Surgical Treatment of Ruptured Intracranial Aneurysms with Deliberate Hypotensive Anesthesia.
Yoon Sun HAHN ; Soo Hue KIM ; Yong Pyo HAN ; Kwang Won PARK ; Hun Jae LEE
Journal of Korean Neurosurgical Society 1973;2(1):9-20
13 cases of intracranial Aneurysm were obliterated intracranially with Heifetz clip under Halothane /O2 Deliberate Hypotensive anesthesia. Deliberate hypotension in the surgery of intracranial aneurysm is used to diminish bleeding and render an aneurysmal sac slack to make clipping easy. Herein is presented a review of clinical experience of deliberate hypotension in conjunction with postural drainage. Clinical investigation has shown that this method offers a wider margin of safety. All factors stressed again the needs for careful, adequate and ideal clippage of the neck of aneurysm preferably with the use of Heifetz clip. Deliberate hypotension and adequate clippage of the neck of aneurysm subsequently allowed a favorable clinical result with an operative mortality by 7.7%.
Anesthesia*
;
Aneurysm
;
Drainage, Postural
;
Halothane
;
Hemorrhage
;
Hypotension
;
Intracranial Aneurysm*
;
Mortality
;
Neck
10.Clinical Analysis of Lower Cervical Spine-Injuried Patients.
Young Rok PARK ; Soon Ki HONG ; Chul HU ; Hun Joo KIM ; Yong Pyo HAN
Journal of Korean Neurosurgical Society 1992;21(6):622-628
The authors analyzed 32 cases with lower cervical spine injuries according to their etiologies, the findings of cervical spine X-ray and computed tomography, initial neurological grading scales and time of operation. The results are summarized as follow: 1) Lower cervical spine injuries occurred in 32 of the 49 cervical spine injuried patients. 2) The important factors affecting on outcome were the initial neurological state(p=0.038) and the degree of spinal canal narrowing on cervical computed tomogram(p=0.046). 3) The degree of prevertebral soft tissue swelling and displacement of vertebral body on initial cervical spine X-ray did not significantly affect on outcome(p=0.052). 4) The most suitable operative time for lower cervical spine injuries was 10-20 days after injuries, and the mortality was 9.3%.
Humans
;
Mortality
;
Operative Time
;
Spinal Canal
;
Spine
;
Weights and Measures