1.A Case of Malignant Lymphoma during Treatment with Methotrexate for Rheumatoid Arthritis.
Moo Gon KIM ; Juhn Yeob LEE ; Jong Seok BAE ; Young Jin SEO ; Kyung Jin LIM ; Seung Hie CHUNG ; Hyundae YOON ; Eun Young KIM ; Wern Chan YOON ; Hun Mo RHEU ; Chae Gi KIM ; Yong Ho SONG ; Chang Ho CHO ; Jung Yoon CHOE
The Journal of the Korean Rheumatism Association 2002;9(1):63-67
Rheumatoid arthritis (RA)is a multisystemic inflammatory disease with a prevalance of approximately 1%of the population.The use of disease modifying anti-rheumatic drug (DMARD)is an essential regimen for the treatment of RA. Among DMARDs,methotrexate (MTX)is used worldwide with confirmed effectiveness.However,cytopenia,pulmonary injury,and hepatic toxicity are a few side effects limiting its use.In addition,although the oncogenic potential of MTX is low,several cases have been reported.Recently an increased risk of developing lymphoproliferative disorders has been reported in patients with RA. The incidence is higher in elderly individuals with severe longstanding seropositive RA,those with Sjogren's or Felty's syndrome,and in patients with RA treated with prolonged low dose MTX.We describe a case of RA who developed non-Hodgkin's lymphoma during low dose MTX therapy.
Aged
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Arthritis, Rheumatoid*
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Humans
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Incidence
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Lymphoma*
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Lymphoma, Non-Hodgkin
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Lymphoproliferative Disorders
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Methotrexate*
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