Of the 11 advanced bladder cancer patients who received M-VAC (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) combination chemotherapy, complete and partial remission were observed in 63.6%. Of the 17 advanced bladder cancer patients who received MAC (Methotrexate, Doxorubicin and Cisplatin) combination chemotherapy, complete and partial remissions were observed in 17%. Complete remission was achieved in 18.2% of the patients clinically, pathologically in M-VAC group and 5.9% in MAC group. Partial remission was occurred in 46.5% of the patients in M-VAC group and 41.2% in MAC group. All metastatic sites including the bone and liver, lung were well responded in M-VAC group, but poorly responded in MAC group. Toxicity was significant but tolerable.
Doxorubicin ; Drug Therapy, Combination* ; Humans ; Liver ; Lung ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Vinblastine

No abstract available.
Emergencies* ; Emergency Service, Hospital* ; Hospitals, Teaching* ; Korea* ; Medical Records*

Limb-girdle muscular dystrophy type 2B (LGMD2B), a subtype of autosomal recessive limb-girdle muscular dystrophy (ARLGMD), is characterized by a relatively late onset and slow progressive course. LGMD2B is known to be caused by the loss of the dysferlin protein at sarcolemma in muscle fibers. In this study, the clinical and pathological characteristics of Korean LGMD2B patients were investigated. Seventeen patients with ARLGMD underwent muscle biopsy and the histochemical examination was performed. For the immunocytochemistry, a set of antibodies against dystrophin, alpha, beta, gamma, delta-sarcoglycans, dysferlin, caveolin-3, and beta-dystroglycan was used. Four patients (24%) showed selective loss of immunoreactivity against dysferlin at the sarcolemma on the muscle specimens. Therefore, they were classified into the LGMD2B category. The age at the onset of disease ranged from 9 yr to 33 yr, and none of the patients was wheelchair bound at the neurological examination. The serum creatine kinase (CK) was high in all the patients (4010-5310 IU/L). The pathologic examination showed mild to moderate dystrophic features. These are the first Korean LGMD2B cases with a dysferlin deficiency confirmed by immunocytochemistry. The clinical, pathological, and immunocytochemical findings of the patients with LGMD2B in this study were in accordance with those of other previous reports.
Adolescent ; Adult ; Age of Onset ; Child ; Creatine Kinase/blood ; Disease Progression ; Female ; Human ; Immunohistochemistry ; Korea ; Male ; Membrane Proteins/biosynthesis ; Muscle Proteins/biosynthesis ; Muscles/pathology ; Muscular Dystrophies/*diagnosis/*metabolism ; Support, Non-U.S. Gov't ; Time Factors

No abstract available.
Blood Flow Velocity*

Atypical polypoid adenomyoma of the uterus is a rare tumor and usually occurs in young women. The most common symptom is abnomal uterine bleeding and the definite diagnosis of the lesions depends on microscopic features. The treatment of this tumor depends on the age of the patient, her desire to retain reproductive function, and the severity of her symptoms. If the patient desires to preserve her reproductive capacity, repeated dilatations and curettages must be done because of the possibility of coexisting endometrial carcinoma. If not, hysterectomy is acceptable. We experienced a rare case of atypical polypoid adenomyoma of the uterus in a postmenopausal woman and report it with brief review of literature.
Adenomyoma* ; Curettage ; Diagnosis ; Dilatation ; Endometrial Neoplasms ; Female ; Humans ; Hysterectomy ; Postmenopause ; Uterine Hemorrhage ; Uterus*

Although inverted papilloma (IP) of the nose and paranasal sinus is a benign neoplasm, it is associated with frequent recurrence and malignant transformation. Various surgical techniques have been employed for resection of this tumor. Transnasal endoscopic medial maxillectomy (TEMM) is an effective surgical management of IP originating from the maxillary sinus. It usually removes the inferior turbinate, lateral wall of the nasal cavity, and nasolacrimal duct, and may cause adverse effects such as atrophic rhinitis, empty nose syndrome, impairment of nasal physiological function, and epiphora. Recently, however, a modified TEMM, which preserves the inferior turbinate, lateral wall of the nasal cavity, and nasolacrimal duct has been introduced. We present two cases of IP successfully treated by the modified TEMM.
Endoscopy ; Lacrimal Apparatus Diseases ; Maxillary Sinus* ; Nasal Cavity ; Nasolacrimal Duct ; Nose ; Papilloma, Inverted* ; Recurrence ; Rhinitis, Atrophic ; Turbinates

Self-ligating brackets have a permanently installed movable component to entrap the archwire which reduces much of the friction created by conventional ligation. Therefore, it allows for rapid tooth movement and shorter overall treatment time. Due to these advantages, interest in self-ligating brackets is increasing. In this report, several practical considerations for using self-ligating brackets are given to appreciate and maximize their benefits. It is thought that self-ligating brackets make shorter and more efficient treatment possible.
Friction ; Ligation ; Tooth Movement

No abstract available.
Lymphocytes* ; Nasal Polyps*

OBJECTIVE: The purpose of this experimental study was to evaluate the effect of immediate orthodontic loading on the stability at the bone-implant interface of titanium miniscrews in a rabbit model. METHODS: Forty titanium miniscrews (1.6 mm diameter, 8 mm length) were inserted in the tibiae of 10 rabbits. Twenty test group miniscrews were subjected to continuous orthodontic forces of 200 g immediately after implantation for a period of 6 weeks. The remaining 20 control group miniscrews were left unloaded for the same follow-up interval. Removal torque values were recorded using a digital torque gauge. An independent t-test was performed. RESULTS: All the miniscrews were stable, and exhibited no mobility or displacement throughout the experimental period. Histologically, miniscrews were well-integrated into bone. No statistically significant differences in removal torque data were found between the loaded test and the unloaded control groups. CONCLUSIONS: These findings suggest that titanium miniscrews can be used as anchoring units for orthodontic tooth movement immediately after insertion.
Follow-Up Studies ; Rabbits ; Tibia ; Titanium ; Tooth Movement ; Torque*

OBJECTIVE: The purposes of this study were to evaluate the differences between sand blasted, large grit and acid-etched (SLA) treated mini-implants and smooth surface orthodontic mini-implants in relation to the removal torque as well as the histologic analysis. METHODS: Custom-made, screw-shaped, titanium implants with a length of 9.5 mm and an outer diameter of 1.8 mm were divided into 2 groups; the SLA group (20 SLA treated orthodontic mini-implants) and the smooth surface group (20 smooth surface mini-implants), and placed in the tibia metaphysis of 10 rabbits. Each rabbit had 4 mini-implants placed, 2 in each tibia. The right tibia were implanted with the SLA group mini-implants and the left tibia had the smooth group mini-implants placed. Each mini-implant group were immediately applied with a continuous traction force of 150 g using a Ni-Ti coil spring. The rabbits were sacrificed 6 weeks post-surgically. Subsequently, the legs were stabilized, the Ni-Ti coil springs were removed and the mini-implants were removed under reverse torque rotation with a digital torque gauge. RESULTS: 6 weeks after placement, the SLA group presented a higher mean removal torque value (8.29 Ncm) than the smooth group (3.34 Ncm) and histologic analysis revealed a higher new bone formation aspect along the screw in the SLA group. CONCLUSION: Results of this study indicates that SLA treated mini-implants may endure higher orthodontic forces without loosening.
Leg ; Osteogenesis ; Rabbits ; Silicon Dioxide ; Tibia ; Titanium ; Torque* ; Traction