AIM: To evaluate the therapeutic effect of treatment with surgery and mifepristone in patients with endometriosis. METHODS: The medical records of 126 endometriosis patients undergoing surgical operation were analyzed retrospectively. There were 28 cases in stage Ⅰ or Ⅱ, 73 cases in stage Ⅲ, and 25 cases in stage Ⅳ. Conservative surgery was performed in 96 cases and semi-conservative surgery in 30 cases. Postoperation, 92 cases continued taking 10 mg?d~ -1 of mifepristone for 6 months and 34 cases did not. All patients received 3 to 5 years follow up. RESULTS: The complete remission (CR) rate in mifepristone group was 77.2 %, partial remission (PR) rate was 22.8 %, and recurrence rate was 16.3 %. The CR of controls was 52.9 %, PR was 47.1 %, and recurrence rate was 32.4 %. There was significant difference between two groups (P

This study was aimed to observe the therapeutic effect of Bushen Tiaogan of traditional Chinese medicine (TCM) herbs combined with clomiphene citrate therapy of promoting small follicular development. A total of 70 small follicle ovulation infertility cases were randomly divided into the control group of 35 cases with the treatment of clomiphene citrate of 50 to 100 mg for 5 days, and 35 cases in the treatment group with TCM herbal medicine of Radix Polygoni Multiflori, Lycium c hinense , eucommia, bupleurum root, turmeric, Fructus aurantii to nourish the kidney and regulate the liver. The clinical efficacy and maximum follicular diameter (MFD) were observed. The results showed that the cycle pregnancy rate in the treatment group was 43 . 59%, and 35 . 13% in the control group. The curative effect of treatment group was obviously superior to the control group. There was statistical significance in the curative effect ( P < 0 . 05 ) . The incidence of LUFS was 7 . 69% in the treatment group , and 29 . 73% in the control group . There was statistical significance ( P < 0 . 01 ) . The MFD value ( 18-28 mm ) in the ovulation cycle, the cycle pregnancy rate was 44.44% in the control group and 55.17% in the treatment group. There was statistical significance difference ( P < 0 . 05 ) . The early abortion rate was 18 . 75% in the control group and 6.25% in the treatment group. There was statistical significance difference (P < 0.01). It was con-cluded that Bushen Shugan Y angyin TCM herbs combined with clomiphene citrate can promote small follicular development with obvious clinical curative effect .

Objective To clone the human β-globin matrix attachment region(MAR) and construct the mammalian animal expression vector pCAT-MAR, which contains the MAR and CAT reporter gene.Methods The human genomic DNA was extracted through phenol/chloroform and precipitated with ethanol, followed the MAR was amplified through PCR using the primers designed according to the GenBank sequence. After identified by agarose gel electrophoresis, sequenced and analyzed by the software, the PCR products were cut with restriction enzymes and ligated into the pCAT3-control vector to construct the pCAT-MAR vector. Results About 770bp band appeared in the agarose gel electrophoresis, the similarly compared with the published MAR sequence was 99.9%, the DNA fragment has the MAR typical features. The pCAT-MAR vector was demonstrated to be right through digestion with the corresponding enzymes and agarose gel electrophoresis. Conclusion The humanβ-globin MAR is cloned through PCR, and the expression vector pCAT-MAR containing the MAR is successfully constructed.

Background and purpose:Cervical cancer is one of the common disease in women in china.Radical surgery remains the first choice for patients with early-stage cervical cancer.However,the majority of patients with bulky disease have lymph nodes or metastases when diagnosed.Palatinum-based neoadjuvant chemotherapy has been utilized in locally advanced cervical cancer with the aim of improving response and survival.The study was to evaluate the effect of neoadjuvant chemotherapy followed by radical surgery for the patients with locally bulky Ⅰ_(B2) and Ⅱ_A cervical carcinoma.Methods:Between September 2003 and February 2004,51 untreated patients with Ⅰ_(B2) and Ⅱ_A cervical carcinoma were enrolled in study group,and were treated with neoadjuvant chemotherapy with cisplatin,vincristine and bleomylin for one cycle followed by radical hysterectomy and pelvic lymphadenectomy;another 51 patients as control group were treated with radical surgery alone.The tumor size,depth of stromal invasion,lymph node metastasis and involvement of surgical specimens were assessed.Results:The overall clinical response rate was 41.2%.There were no complete and progressive ones.The blood loss during operation was 116.82?45.50ml,it was significantly lower than that in control group(P

Purpose To study the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI),diffusion tensor imaging (DTI) and the combination of these two techniques in benign and malignant nodules of central prostate gland.Materials and Methods Forty-nine patients with nodular abnormal signal in central prostate gland who had accepted prostate MRI scan in Shihezi University Medical College First Affiliated Hospital from September 2015 to December 2016 were retrospectively analyzed,and all the subjects had accepted MRI T2WI,DTI and DCE scan.The pathological results confirmed that there were 21 prostate cancer (PCa) and 36 benign prostatic hyperplasia (BPH) among 57 central gland nodule samples.The fractional anisotropy value,apparent diffusion coefficient value,time to peak,SImax,the curve slope and timesignal intensity curve of nodules were respectively detected,the differences of the parameters between PCa group and BPH group were compared,and receiver operating characteristic (ROC) curve analysis was carried out.Results The difference of fractional anisotropy value,apparent diffusion coefficient value,time to peak and R between PCa group and BPH group was statistically significant (P＜0.05),and there was no significant difference in SImax (P＞0.05);the time-signal intensity curve type of PCa group was mainly in the form of fast-increasing and then decreasing,while the curve type of BPH group was mainly in the form of platform.The area under the ROC curve of DCE,DTI and the combination of DEC and DTI were 0.87 (95％ CI:0.751-0.942),0.85 (95％ CI:0.734-0.933) and 0.94 (95％ CI:0.837-0.983),respectively.Conclusion In the cases of diagnosing benign and malignant nodules of central prostate gland,the accuracy of DTI and DCE was lower than that of the combination of these two techniques,and the diagnostic effect of DTI combined with DCE was better.

Objective To investigate the relationship factor of livability on Premature Very Low-Birth-Weight-Infant (PVLBWL), for refer to evidences that reduce the mortality and the deformity rate. Methods The group 116 PVLBWL cases, being in our hospital hear five years, divide into three team according to the weight, and analyze the review clinical data of the cases (from 1993.1 to 1998.1). Results There are 86 cases that had cured and left hospital in the group. The cure rate is 74.1%(86/116). It is rise along with the weight increase (P

Objective To explore the methods of breast tumor surgery information platform construction.Method To construct the information platform from target location,overall framework,function etc.Result The building of information platform provided a full range of care for breast cancer patients.Conclusion The construction of information platform can further improve the quality of nursing in breast cancer patients.

OBJECTIVE To analyze the reason of hospital infection by meticillin-resistant Staphylococcus aureus(MRSA) popular on the wound surface in burn wards at a hospital located in South China.The methods of prevention and control were discussed.METHODS The MRSA infections on the surface of a wound of patients in burn wards were reviewed and analyzed from Sep 20,2005 to Sep 30,2005.The occurred reasons,distributed characteristics and drug resistance were carried out on the analysis.RESULTS There were 6 cases of MRSA infection on the injured area,from them 4 with third-degree burn,and 2 with moderate burn.The patients were cured completely.There was no blood stream MRSA infection.Vancomycin was used to treat.The fulminant epidemic of MRSA infection in the injured area was related with environment pollution and cross infection caused by the imprecise aseptic operation.CONCLUSIONS The injured area of burn patient is infected by MRSA.which often has strong drug resistance,but the vancomycin is effective.The environment disinfection is important.Medical personnel's standardized aseptic operation should be strengthened.The reasonable use of antibiotics can avoid the cross infection.It is the important method to prevent and control the fulminant epidemic.

Balb/c mice with HAC murine hepatic cancer were fed with oyster extract at a daily dose of 0. 2 ml (20 mg) for ten successive days. We found that the tumor-caused decreased immunological indicarors including total T cell number, the ratio of helper T cells, the transformation strength induced by mitogens, and NK activity increased markedly. Compared with the control, mice fed with oyster extract showed prolonged survive and their tumor weight reduced significantly. When mice earring human colon cancer were fed with oyster extract at the same dose for 15 days, the tumor size reduced to 44. 6% of the control tumors. The possiblity that oyster extract inhibits tumor growth by enhencing host immune function, especially killer cell activity, was discussed.

Objective To detect the safe application of autoblood re-trasfusion of medical trioxyen. Methods 50 patients who received fundamental autohemotherapy with German DR.HANSLER OZONOSAN treating system were extracted 100ml venous blood,which was mixed with 100ml,10~20?g/m1 medical trioxyen and then retransfused into the patients.We observed the adverse effect during the course of treatment and measured the blood pressure and blood glucose of every patient accordingly. Results Among the 50 cases,4 (about 8%) had adverse effect after blood extracting. 5 cases (about 10%) had adverse effect after the trioxyen re-transfusion. The cardinal symptoms included:dizziness,nausea,emesia,cold sweat,blood pressure decrease,shock etc. Conclusion Before retransfusing the medical trioxyen,handling the indications,contraindications,making the patients have good sleep and diet and have necessary comunication with them can make the negative reaction lower at most.