OBJECTIVE: To investigate the mechanisms of tumor inhibiting and immunoloregulation of Mylabris Mixture on H22 cancer-bearing mice. METHODS: H22 cancer-bearing mice were chosen to observe the effects of tumor inhibiting and detect the proliferation function of T lymphocytes, the toxicity function of NK cells, the changes of T lymphocytes and the contents of interferon-gamma and interleukin-4. RESULTS: Mylabris Mixture could obviously inhibit the growth of H22 cancer in mice, and the tumor inhibition rat was 65.76%. The stimulation index of T lymphocyte transformation and percentage of NK cells in Mylabris Mixture-treated group were obviously higher than those in the normal control group. The subpopulation proportion of T lymphocytes in Mylabris Mixture-treated group was changed more than the normal control group. The production of interferon-gamma and interleukin-4 by T lymphocytes obviously increased in Mylabris Mixture-treated group (P<0.05, P<0.001). CONCLUSION: Mylabris Mixture has the effect of inhibiting the growth of tumor constitution, and regulating immunological function on mice with tumor. Its mechanisms include the reinforcement of T lymphocyte immune function, NK cell killing function and humoral immune function.

Objective To explore the influence of MiniQuest teaching model on improving critical thinking ability of nurses in Department of Orthopedics. Methods From January to May 2017, 76 nurses in Orthopedics Department from 4 Class Ⅲ hospitals of one province were selected as the research objects. The nurses of 2 hospitals were set up as the observation group by drawing method of head nurse, and the nurses of the other 2 hospitals were set as the control group, with 36 cases in the observation group and 40 in the control group. The nurses in the control group were taught by routine department work. The observation group was trained with MiniQuest teaching method, and the Critical Thinking Ability Scale was used to compare the critical thinking of 2 groups of nurses. Results The fact finding, open thinking, analytical ability, systematic ability, critical thinking self-confidence, cognitive maturity and total score of the Critical Thinking Ability Scale of the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). There was no significant difference in the score of dimension of thirst for knowledge between the two groups of nurses (P>0.05). Conclusions MiniQuest teaching model can improve the critical thinking ability of nurses in department of orthopedics, and it is worthy of popularizing.