Objective To investigate blood glucose,HbA1c and GA levels in patients with acute cerebral infarction.Methods 129 patients with acute cerebral infarction and 102 healthy persons were recruited.Blood glucose,HbA1c and GA levels were com-pared between acute infarction patients and healthy people.The correlation of blood glucose,HbA1c and GA with different degree of neurological deficits,number and sizes of infarct lesions and prognosis were explored.Results Fasting plasma glucose,HbA1c and GA levels in patients with acute cerebral infarction were significantly higher than in healthy people(P <0.05).GA and HbA1c levels were higher in patients with more severe degree of neurological deficit,larger infarct volume and poorer prognosis,and the differences were statistically significant (P <0.05).GA level was significantly higher in patients with multifocal infraction than pa-tients with single(P <0.05),however,there were no differences of HbA1c between the two groups.No significantly differences of fasting blood glucose were found among the patients classified with neurological deficit,number and sizes of infarct lesion and prog-nosis(P >0.05).Conclusion Blood glucose,HbA1c and GA levels were closely related with neurological deficit,severity and prog-nosis of acute cerebral infarction,thus determination of these indicators is of important clinical significance.

Objective·To explore the expression of sorting nexin 1(SNX1)in colorectal cancer(CRC)and its impact on the proliferation and migration of CRC cells.Methods·Transcriptomic data and clinical pathological information of CRC were obtained from The Cancer Genome Atlas(TCGA),Genotype-Tissue Expression(GTEx),and Gene Expression Omnibus(GEO)databases for enrichment analysis with Gene Set Enrichment Analysis(GSEA)software.The expression of SNX1 in CRC tissues and cells was detected by quantitative real-time polymerase chain reaction(qPCR),Western blotting,and immunohistochemistry staining(IHC).Small interfering RNA(siRNA)was used to knock down the expression of SNX1 to observe its effect on tumor cell proliferation and migration.Correlation analysis was conducted to explore the potential molecular mechanisms underlying SNX1-mediated CRC cell migration,and mRNA level validation was performed in SNX1 knockdown cell lines.Results·Analysis of CRC patients data in TCGA and tissue microarrays revealed that SNX1 expression was downregulated in CRC tissues and correlated with tumor diameter and distant metastasis.Knockdown of SNX1 enhanced tumor cell proliferation and migration.The expression of SNX1 was negatively correlated with metastasis associated in colon cancer 1(MACC1),mesenchymal to epithelial transition factor(MET),and Notch;knockdown of SNX1 led to upregulation of these genes.Silencing SNX1 resulted in the downregulation of the epithelial marker cadherin 1(CDH1)and the upregulation of vimentin(VIM)and Snail family transcriptional repressor 1(SNAI1).Conclusion·SNX1 expression was significantly downregulated in CRC tissues and correlated with patient prognosis.Low expression of SNX1 enhanced the proliferation and migration of CRC cells and was associated with the MACC1-MET pathway and EMT.SNX1 may serve as a potential biomarker for poor prognosis and a novel therapeutic target in CRC.