Objective To explore the evidence- based nursing measures of stress ulcer in children after gastrointestinal surgery. Methods The evidence-based individualized care was performed on 10 cases of children with stress ulcer after gastrointestinal surgery by reviewing the literature. Results Children with stress ulcers were cured, in stable condition, successfully evacuated from mechanical ventilation, and transferred to the general ward. Conclusions Based on the evidence-based nursing of stress ulcer in 10 children after gastrointestinal surgery, the evidence-based nursing was obtained, which can provide evidence for the future nursing of stress ulcer.