1.Research progress on the effect of single nucleotide polymorphism on drug efficacy of Alzheimer′s disease
Minmin ZHAN ; Huixuan MA ; Xuechun KANG ; Xinliang LU ; Shuting GONG ; Qi ZOU ; Jianping JIA ; Cuibai WEI
Chinese Journal of Neurology 2021;54(7):723-728
Alzheimer′s disease is a progressive neurodegenerative disease that requires medication to improve patient symptoms, but there is an individual difference in the efficacy. In this paper, the correlation between single nucleotide polymorphism and the drug efficacy of Alzheimer′s disease (AD) in the past 20 years was searched through the databases of China National Knowledge Infrastructure, VIP Database, Wanfang Database, Pubmed, Springer Link and Cochrane Library with key words of Alzheimer′s disease, drug efficacy, single nucleotide polymorphism. The correlation between AD drug efficacy difference and gene single nucleotide polymorphism was reviewed, including ABCA1, ApoE, ChAT, CHRNA7, IL-6, A2M, CYP2D6, BChE, 5HT2a, PON-1 and ESR1 genes, so as to provide a reference basis for clinicians to select drugs in the treatment of AD.
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