In this paper, from the current situation of the domestic use of superconducting MRI, on liquid helium supply and demand crisis in the market, the significance of the transformation without LHe of the superconducting MRI magnet was explained, and according to the enterprise's production process, a number of operating without liquid helium transformation practice and ideas were raised, important value orientation for the domestic manufacture and use of superconducting MRI was provided.
Equipment Design ; Magnetic Resonance Imaging ; instrumentation ; Magnetics ; instrumentation

More recently, a high incidence of antisperm antibodies in men and women with unexplained in fertility has been reported by many authors. However, the antisperm antibodies may play a role in mediating in fertility by interacting with sperm. The effect of antisperm antibodies on the phagocytosis of rat peritoneal macrophages were studied in vitro. The results indicated that opsonization of rat sperm by rabbit anti-rat sperm antibodies increases both the percentage of phagocytosis and phagocytic index apparently. The engulfed sperm when observed by SEM were bended and wrapped up. It seems likely that antisperm antibodies enhanced phagocytosis by macrophages may take part in the antisperm immune responses.

We studied the effects of oxymatine,an alkaloid from Sophra Flavesens Ait,on human andmouse's lymphocytes' cytoplasmic free calcium,calium uptaking,cAMP & cGMP level.Theresults show that:(1).Oxymatrine can raise the cytoplasmic free calcium.(2).It can also de-crease the cAMP level of PHA preactivated human tonsillar lymphocytes (3).It has no effect oncGMP level of lymphocyte.(4).It has no effect on the calcium uptaking.Combined with ourprevious report,we think that oxymatrine may influence cells' [Ca++] and cAMP level via af-fecting cell membrane.

Chronic hepatitis B virus (HBV) infections remain a major public health problem worldwide, which puts human at high risks of liver cancer and liver cirrhosis.The stable nuclear covalently closed circular DNA (cccDNA) is an important step of the HBV replication cycle, as well as the key of drastically destroy the HBV.However, α-interferons and oral nucleo(s) tide analogs cannot target and destroy the cccDNA.Nowadays, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing technology can specifically target the HBV cccDNA, which brings hope to conquer HBV.Researches of CRISPR/Cas9 technology applied to clear HBV have been reviewed in this paper.

Hereditary nonpolyposis colorectal cancer as a eolorectal cancer is of most hereditary characters.With developing of the molecular genetics on detection technology,mismatch repair gene has already been detected by multi-approach,and been applied to screen hereditary nonpolyposis eolorectal cancer patients.In this artical,we mainly discuss the correlated study progression between hereditary nonpolyposis eolorectal cancer and several mismatch repair genes such as MSH2,MLH1,MSH6,PMS1,PMS2,MLH3 and EXO1.

Objective The aim of this study was to evaluate the clinical value and the possibilities of measuring the serum levels of pepsinogen I (PG I ) and careineembryonic antigen (CEA) in 402 patients with gastric ulcer.Methods The patients with gastric ulcer were all confirmed by either operation or gastrofiberscope,and divided into two groups,benign and malignant gastric ulcer.After comparing the relationship between the patients'clinical appearance and the Radioimmunoaasay(RIA) results,(CEA and PG I ).Results There were 73 patients were onfirmed malignant gastric ulee in 402 patients.The positive rate of PG was 52.05% (38/73).The positive rate of CEA was 64.38% (47/73).Both were 30.14% (22/73).Then there were 63(63/73) patients who was positive in the combined determination.Solo determination's positive rate of CEA and PG were significantly different from the combined determination.(P＜0.05 and 0.01) Conclusions Feasibility and the necessity of combined determination were evaluated.Compared with solo determination,for patients with malignant gastric ulcer,it was more sensitive to determine and analysis the serum levels of PG I and CEA sYnthetically.So it is recommended to popularize the combined determination of serum PG I and CEA in clinical distinctive diagnosis of benign and malignant gastric ulcer.

Primary liver cancer is a common malignant tumor in the digestive system.Most patients are in the advanced stage when a con-firmed diagnosis has been made,and prognosis is often unfavorable.Traditional Chinese medicine (TCM)has unique advantages in the pre-vention and treatment of primary liver cancer.This article briefly introduces the etiology and pathogenesis of primary liver cancer,as well as syndrome differentiation and treatment of liver cancer with TCM,and summarizes the advances in multimodality therapies including TCM combined with transcatheter arterial chemoembolization,radical surgery for liver cancer,chemoradiotherapy,and molecular-targeted thera-py,in order to provide a reference for the clinical treatment and improvement in the prognosis of primary liver cancer.

Objective To study the route of branches of the internal iliac artery for presenting basic applied anatomy to be used in pelvic tumor diagnosis and interventional therapy through angiographic manifestations. Methods The branches of the internal iliac artery were studied by means of dissection on 45 adult cadavers(30 male, 12 female), including the origin, length, external diameter and bifurcation angle; and additionally angiographic characteristics of pelvic tumors in 42 cases together with normal ones of another 50 cases through bilateral selective internal iliac arteriography. Results①The angle between left and right common iliac artery was (58.9??7.3?),and that between the external and internal iliac artery was (27.6??5.3?). Iliolumbar artery and obturator artery were mainly originated from the main trunk of internal iliac artery and the distal portion (50%, 84.8%).②The external diameter of the branches of the internal iliac artery measured on cadavers was significantly smaller than that on patients alive. Conclusions Normal variations occur frequently in the origination, site of orifice and route of the middle and small branches of the internal iliac artery.

Objective To screen the formulation for tanshinone self-emulsifying drug delivery system (SEDDS) and evaluate its stability.Methods The optimal tanshinone SEDDS formulation was established through solubility experiment,emulsion examination,fully emulsified time,droplet size determination,and pseudo-ternary diagram drawing.The content and stability were evaluated by HPLC assay under the condition of illumination,high and low temperature.Results The oil phase,surfactant and co-surfactant in the optimal tanshinone SEDDS formulation were ethyl oleate,TX10,Tween 80,and isopropyl alcohol (60∶84∶21∶35).Conclusion The acquired formulation of tanshinone SEDDS is stable in the dark and room temperature.