In this paper, from the current situation of the domestic use of superconducting MRI, on liquid helium supply and demand crisis in the market, the significance of the transformation without LHe of the superconducting MRI magnet was explained, and according to the enterprise's production process, a number of operating without liquid helium transformation practice and ideas were raised, important value orientation for the domestic manufacture and use of superconducting MRI was provided.
Equipment Design ; Magnetic Resonance Imaging ; instrumentation ; Magnetics ; instrumentation

More recently, a high incidence of antisperm antibodies in men and women with unexplained in fertility has been reported by many authors. However, the antisperm antibodies may play a role in mediating in fertility by interacting with sperm. The effect of antisperm antibodies on the phagocytosis of rat peritoneal macrophages were studied in vitro. The results indicated that opsonization of rat sperm by rabbit anti-rat sperm antibodies increases both the percentage of phagocytosis and phagocytic index apparently. The engulfed sperm when observed by SEM were bended and wrapped up. It seems likely that antisperm antibodies enhanced phagocytosis by macrophages may take part in the antisperm immune responses.

We studied the effects of oxymatine,an alkaloid from Sophra Flavesens Ait,on human andmouse's lymphocytes' cytoplasmic free calcium,calium uptaking,cAMP & cGMP level.Theresults show that:(1).Oxymatrine can raise the cytoplasmic free calcium.(2).It can also de-crease the cAMP level of PHA preactivated human tonsillar lymphocytes (3).It has no effect oncGMP level of lymphocyte.(4).It has no effect on the calcium uptaking.Combined with ourprevious report,we think that oxymatrine may influence cells' [Ca++] and cAMP level via af-fecting cell membrane.

Chronic hepatitis B virus (HBV) infections remain a major public health problem worldwide, which puts human at high risks of liver cancer and liver cirrhosis.The stable nuclear covalently closed circular DNA (cccDNA) is an important step of the HBV replication cycle, as well as the key of drastically destroy the HBV.However, α-interferons and oral nucleo(s) tide analogs cannot target and destroy the cccDNA.Nowadays, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing technology can specifically target the HBV cccDNA, which brings hope to conquer HBV.Researches of CRISPR/Cas9 technology applied to clear HBV have been reviewed in this paper.

Thirty three tibial fractures treated with interlocking intramedullary nail(IMN) were reviewed. Of all the patients, 16 were fixed with reamed IMN, and 17 with nonreamed IMN. There were 22 closed and 11 open fractures. Twenty seven patients were followed up for an average of 17.9 months (4 to 31 months). Of all the patients, 22 healed in 6 months, delayed healing occurred in 1,and in 1 the distal locking screw was broken. In the close fractures, the mean time from fracture to operation was 3.55 days (from the injury day to 27 days) , and in the open fractures operation was all done on the day of injury. Nonreamed IMN was used in 12 closed fractures (54.5%, 12/22 ) , and reamed IMN was used in 4 open fractures (36.3%, 4/11). There was no postoperative compartment syndrome or infection. The interlocking intramedullary pin is indicated for the tibia fractures, and early operation is feasible . The nonreamed interlocking intramedullary pin is suitable for open fractures and multi injuries.

Anopheles minimus was infected with Plasmodium yoelii yoelii under adequate condition. The malaria parasite could develop normally and produce mature oocysts containing sporozoites. Large numbers of free active sporozoites were found in the haemocele but most of them failed to penetrate into the mosquito's salivary glands. Thus the sporogonic cycle of the parasite could not be completed.But in one mosquito, a few sporozoites were found in its salivary glands. It seems that there is an individual difference in the susceptibility of the mosquitoes and this throws some light on the possibility of selecting a susceptible strain of A. minimus to establish the A. minimus-P. yoelii system for malaria research.

Objective To investigate the effect of herbal foot-bath plus acupoint application on sleep quality of stomach cancer patients before surgery. Method Eighty eligible patients who were going to receive stomach cancer surgery were randomized into an observation group and a control group, 40 in each group. The control group was given psychological comfort plus switching off lights on time, while the observation group was additionally given herbal foot-bath plus acupoint application before the surgery. The sleep quality on the night before surgery was observed. Result There were significant differences in comparing sleep latency, night wakening, total sleep duration, total sleep quality, daily body function and total score (P<0.05). Conclusion Herbal foot-bath plus acupoint application can enhance the effective sleep duration and sleep quality of patients before stomach cancer surgery.

Primary liver cancer is a common malignant tumor in the digestive system.Most patients are in the advanced stage when a con-firmed diagnosis has been made,and prognosis is often unfavorable.Traditional Chinese medicine (TCM)has unique advantages in the pre-vention and treatment of primary liver cancer.This article briefly introduces the etiology and pathogenesis of primary liver cancer,as well as syndrome differentiation and treatment of liver cancer with TCM,and summarizes the advances in multimodality therapies including TCM combined with transcatheter arterial chemoembolization,radical surgery for liver cancer,chemoradiotherapy,and molecular-targeted thera-py,in order to provide a reference for the clinical treatment and improvement in the prognosis of primary liver cancer.

Objective:To optimize the compatibility conditions of erigeron injection and study the stability after compatibility. Methods:An orthogonal test was employed using the quantity of insoluble particles and the content of rutin as the indices and tempera-ture, solvent and solvent amount as the influencing factors. The results were comprehensively analyzed. According to the results of the orthogonal test, three batches of samples were prepared and observed the stability in 24 hours, including the changes in the number of insoluble particles, pH and total flavonoid content. Results:The optimal compatibility conditions were as follows:the temperature was 25℃, and 250 ml 0. 9% sodium chloride injection was used as the solvent. The appearance and the insoluble particles showed no sig-nificant changes in 24 hours. The total flavonoid content was also stable in 4 hours, but decreased to some extent after then. Conclu-sion:At the clinical dose, erigeron injection in 250 ml 0. 9% sodium chloride injection can keep stable in 4 hours.