Objective:To investigate the incidence of social isolationin community elderly patients with knee osteoarthritis and analyze its influencing factors.Methods:From January to April 2021, 240 community elderly with knee osteoarthritis in three community health service centers in Taiyuan (Yingbin community, Dawang community and Pingyang second community) were selected as research objects by convenient sampling method. They were investigated by general data questionnaire, Lubben Social Network Scale-6(Lubben-6), Geriatric Depression Scale-15, Perceived Social Support Scale, Numerical Rating Scale. Single factor analysis and binary Logistic regression analysis were used to explore the influencing factors of social isolation in elderly patients with knee osteoarthritis.Results:The prevalence of social isolation among community elderly patients with knee osteoarthritis was 43.33% (104/240) . The results of binary logistic regression analysis showed that age ( OR = 2.228, 95% CI 1.436-3.457), complicated diseases ( OR = 1.733, 95% CI 1.028-2.919), exercise ( OR = 0.560, 95% CI 0.360-0.869), depression ( OR = 3.603, 95% CI 1.768-7.339), comprehension of social support ( OR = 0.424, 95% CI 0.253-0.710) and pain ( OR = 1.792, 95% CI 1.147-2.799) were the influencing factors of social isolation in elderly patients with knee osteoarthritis ( P<0.05). Conclusions:The degree of social isolation in community elderly patients with knee osteoarthritis is relatively high, and is affected by many factors. Community medical staff should formulate targeted nursing intervention plans based on their influencing factors to reduce the occurrence of social isolation.

OBJECTIVETo compare the clinical characteristics, treatment methods and outcomes in Chinese non ST-segment elevation acute coronary syndrome (NSTE-ACS) patients from two large clinical trials in different time periods.

METHODSAll Chinese NSTE-ACS patients from two large International clinical trials (OASIS Registry and TIMACS) underwent coronary artery angiography after first admission were recruited in our analysis. The follow-up time was 180 days. A total of 1 473 NSTE-ACS patients were recruited in this analysis, in which 749 from Organization to Assess Strategies for Ischemic Syndromes (OASIS REISTRY) that completed in 38 centers in China from April 1999 to December 2000, and the rest 724 patients from The Timing of Intervention in Acute Coronary Syndromes (TIMACS) trial in 24 centers in China performed from April 2007 to June 2008.

RESULTSCompared to OASIS patients, TIMACS group were older ((64.2 ± 10.1) years old vs. (58.7 ± 10.2) years old) , and fewer male patients (66.3% (480/724) vs. 74.4% (557/749)) , lower blood pressure at admission, and more histories of previous PCI (9.4% (68/724 vs. 6.4% (48/749)), stroke (8.8% (64/724) vs. 5.1% (38/749)) , hypertension (62.8% (455/724) vs. 56.6% (424/749)) and diabetes (23.3% (169/724) vs. 16.2% (121/749)), lower histories of coronary artery disease (37.4% (271/724) vs. 59.1% (443/749)) and myocardial infarction (12.0% (87/724) vs. 27.6% (207/749)) (all P < 0.05). After admission, comparing to OASIS group, TIMACS patients had significant higher PCI proportion (74.9% (524/724) vs. 49.3% (369/749), P < 0.001). In addition, for secondary prevention, TIMACS patients had significant higher standard medication treatment proportion during hospitalization, at discharge and at 180 days follow up than OASIS group (P < 0.05 for β-blocker, ACEI/ARB and lipid lowering drugs) and higher compliance rate. The combined primary outcome event rate at 180 days was much lower in TIMACS than in OASIS patients (13.3% (96/724) vs. 25.2% (189/749), P < 0.001) mostly due to the reduction on the refractory angina (5.2% (38/724) vs. 22.6% (169/749), P < 0.001) .

RESULTSof COX regression model adjusted for baseline levels and treatment during hospitalization showed that the incidence rate of combination endpoint (HR = 0.39, 95% CI: 0.29-0.53, P < 0.001) and refractory ischemia/angina rehospitalization (HR = 0.17, 95% CI: 0.11-0.25, P < 0.001) were both lower in TIMACS patients than in OASIS patients.

CONCLUSIONPCI procedure and secondary prevention medication administration are more often applied in TIMACS patients than in OASIS group, which is related to less integrated incidence of primary outcomes reflecting progress in Chinese medical care for non ST elevated acute coronary syndrome patients according to the updated guidelines.

Acute Coronary Syndrome ; prevention & control ; therapy ; Adrenergic beta-Antagonists ; Aged ; Arrhythmias, Cardiac ; Brugada Syndrome ; Cardiac Conduction System Disease ; Cardiovascular Diseases ; China ; Coronary Angiography ; Coronary Disease ; Female ; Heart Conduction System ; abnormalities ; Humans ; Hypertension ; Incidence ; Male ; Middle Aged ; Myocardial Infarction ; Prognosis ; Registries ; Secondary Prevention ; Time Factors