ObjectiveTo observe the effects of nasal continuous positive airway pressure(NCPAP) on neonatal respiratory disease.Methods67 newborns with respiratory disease undergone the treatment of NCPAP and routine clinic treatment.The changes of blood gas index and therapeutic effects were observed.The changes of blood gas between the pretherapy and post-treatment were compared.ResultsThe numerus of PaO2,SpO2 was increased apparently at 1 hour after treament with NCPAP.The difference was significant ( t =3.84,15.50,all P ＜ 0.05 ).But the PaCO2 had no apparent change and the difference was not significant(t =1.96,P ＞ 0.05 ).54 newborns were treated successfully and 13 newborns were treated unsuccessfully.51 newborns were cured,11 newborns were improved and 1 patient was dead at Last.ConclusionThe early application of NCPAP on neonatal respiratory disease was very effective.It could reduce the use of mechanial ventilation,and it was a convenient,safe and effect-prominent method.

Toll-like receptor( TLR) ,which belongs to pattern recognition receptor,is type I transmem-brane glycoprotein. TLR activates natural immune and induces several cytokines. Foreign studies have showed that bacterial infection is closely related with TLR. In this paper,the relationship between TLR and bacterial in-fection is reviewd.

Objective To observe and analyze the clinical effect of aerosol inhalation with budesonide suspension liquid drug in the treatment of children with acute infectious laryngitis.Methods 76 children with acute infectious laryngitis were divided into the observation group (n=38) and control group (n=38).Two groups of chil-dren were treated with conventional therapy,on the basis of conventional therapy,the control group was given dexam-ethasone aerosol inhalation,the observation group was treated with atomization of inhalation with budesonide suspen-sion liquid.The clinical therapeutic effects of the two groups were assessed.Results The total effective rate of the observation group was 97.37%,which was significantly higher than 76.32% of the control group,the difference was statistically significant (χ2 =19.392,P<0.05).The disappeared time of fever,cough,hoarseness,dyspnea,throat beep symptoms in the observation group was (2.21 ±1.12)days,(2.21 ±0.54)days,(1.21 ±0.33)days,(1.61 ± 0.81)days,(1.23 ±0.21)days,which were significantly shorter than the control group,the differences were statisti-cally significant (t=4.118,4.362,6.369,3.943,3.946,all P<0.05).The two groups had no obvious adverse reac-tion,The duration and hospitalization time of the observation group were (2.11 ±0.72)days,(3.09 ±0.54)days respectively,which were significantly shorter than the control group (t=4.966,5.795,all P<0.05).The satisfaction rate of the observation group was (91.23 ±4.52)%,which was significantly higher than the control group,the differ-ence was statistically significant (χ2 =4.203,P<0.05).Conclusion For the children with acute infectious laryngi-tis,inhalation with budesonide suspension liquid therapy can significantly improve clinical symptoms,with no adverse reaction,shorten the course of disease and hospitalization time,reduce the physical and psychological suffering of chil-dren,improve the clinical treatment effect,promote the healthy growth of children,it is worthy of clinical application.

The status quo of pain,trigger mechanism of pain,the manner of pain valuation and painalleviating measures during wound dressing were analyzed by checking literatures at home and abroad.These studies implied that the dressing-related pain impacted not only wound healing but also patients' daily life.At the same time,the studies and clinic practice of dressing-related pain in China were relatively deficient,therefore it is important that clinic practitioner should pay more attention to awareness of dressing-related pain and pain causes and take measures to relieve pain.

Objective:The purpose is to observe the clinical results of the continuous douche and negative pressure drainage technic in treating the large hypodermal infected lacuna. Methods: The simple mini-size perfusion cannula for continuous douche and negative pressure drainage was handmade and used on 23 patients suffering from large hypodermal infected lacuna. Results: All of the 23 patients achieved primary healing from large hypodermal infected lacuna. Conclusion:The use of self-made mini-size perfusion cannula for continuous douche accompanied with negative pressure drainage is a good method to treat large hypodermal infected lacuna. It is very economic、efficient and easy.

Objective To investigate the mechanism of anti-aging effect of Yangyan Quban particles on the aging skin. Methods With the dose of D-galactose 1000 mg/(kg?d) by sc administration to the female mice for 42 days, the aging model was established. The mice received Yangyan Quban particles (6.68, 3.34, 1.67 g/kg) by ig administration at the same time of injecting D-galactose. Forty-two days later, the dorsal skin samples were collected to determine glutathione peroxidase (GSH-Px) activity and serum estradiol (E2) contents, and the influence on uterus, ovary, skin dry and wet weight and the amount of water intake were studied. Results Compared with the aged model mice, the GSH-Px activity and E2 contents in the mice treated with Yangyan Quban particles were increased remarkably, especially the medium is the best dose (P

Objective To evaluate the early clinical outcome of one‐stage posterior approach operation for rigid scoliosis caused by lumbosacral hemivertebra in adolescencts .Methods Eighteen adolescencts with rigid scoliosis caused by lumbosacral hemivertebra were surgically treated by the posterior hemivertebral resection and long segment fixation .Hemivertebrae were sited in L5 (14 cases) ,S1 (4 cases) .There were 12 cases of full‐segmented hemivertebrae and 5 cases of semi‐segmented hemivertebrae and 1 case of wedge vertebral body ,10 patients had coronal trunk imbalance .Results The patients were successfully completed sur‐gery .The operation time was 4 .5-8 .5 h ,averaged 6 .3 h ;and the perioperative bleeding was 600-2 800 mL ,averaged 1 180 mL . 2 patient suffered from nerve root injury who received neuro nutrition drugs and Prednisolone after operation and recovered com ‐pletely after one weeks .All cases were follow ed up for 12-38 months ,averaged 21 .6 months .The coronal Cobb angles of lumbo‐sacral curve and proximal lumbar after one week of operations and at the time of the last follow‐up were much better than those be‐fore the operations ,the differences were statistically significant (P<0 .05) .Postoperative radiography demonstrated that no implant failure was observed .Coronal trunk shift was improved in 17 patients after surgery ,1 patient had coronal trunk decompensation . Conclusion The posterior surgery with hemivertebrae resection and long segment fixation is an effective procedure in the treatment of rigid scoliosis caused by lumbosacral hemivertebra in adolescencts .The reconstruction of the coronal plane is the key to the oper‐ation .

Objective To explore protective effects of ulinastatin on lung injury and inflammation in patients received pulmonary surgeries.Methods 36 patients received pulmonary surgeries were randomly divided into control group and experimental group,and OLV was applied during surgeries.Additionally,ulinastatin was given to experimental group.Serum levels of IL-6,IL-10 and TNF-alpha were observed at different time after OLV by ELSIA.The expression of AQP-4 was observed by immunohistochemistry.Results Serum levels of IL-6,IL-10 and TNF-alpha increased significantly in all patients after OLV was applied(P ＜0.05).The levels of IL-6 and TNF-alpha increased more significantly in experimental group than control group at all time points.The expression of AQP-4 increased significantly in experimental group than control group(t =10.29,P ＜ 0.05).Conclusion Conclusion Ulinastatin shows protective effects on lung injury during pulmonary surgeries,mainly via attenuating inflammation reactions and expression of AQP-4.

Objective To explore the clinical practice and patient experience of perioperative therapeutic communication in rectal cancer patients, in order to provide theoretical basis for the further clinical application of therapeutic communication. Methods To adopt phenomenology method of qualitative research, collecting data by the direct participation, observation, half structural formula thorough interview and other methods. To establish coding and refine theme. Results Four themes of the rectal cancer patients experience of perioperative therapeutic communication were generalized: emotional adaptation, actively coping with surgery, intraoperative cooperation, postoperative rehabilitation and self-care. Conclusions Application of therapeutic communication system can effectively interfere with patients cognitive behavior, improve communication ability of nurses and extended the nursing service connotation.

Objective To discuss the clinical and pathological features of herniation secondary to cerebral infarction. Method Clinical and pathologic characteristics of 50 cases died of herniation due to cerebral infarction were analysised. Results The clinical manifestations,such as consciousness disturbance,pupillary change,hemiplegia or tetraplegia were detected in all 50 cases,the average time from onset to herniation was (3.36?1.12)d,the time herniation to death was 20 h～7 d,average about (1.5?0.98)d. The large size cerebral infarctions caused by internal carotid artery,middle cerebral artery and/or vertebral artery occlusion were pathologically confirmed.hemorrhagic cerebral infarctions caused by cerebral embolism were found in 25 cases and the ischenmic infarctions caused by cerebral thrombosis in 25 caese.Site of infarction were cerebral hemisphere (31 cases), brain stem (15 cases), supratentorial and infratentorial brain (4 cases).Of the 50 cases,36 cases had hippocampal gyrus herniation,36 cases with cerebellur throat-almond herniation,18 cases with central herniation,17 cases with cingulated gyrus herniation,and 27 cases with sphenoidal crest herniation. Usually there were several herniation existing in the same patient. Among 50 cases,11cases had two kinds of herniation,10 cases with three kinds of herniation,9 cases with four kind of herniation, and 5 cases with five kinds of herniation.Conclusions Herniation secondary to cerebral infarction were mainly presented in the large size cerebral infarction caused by internal carotid artery or middle cerebral artery occlusion.the time of herniation was in early stage of disease.Most of patients were hippocampal gyrus herniation and cerebellur throat-almond herniation.Usually there were several herniation existing in the same patient.