Objetive: To investigate the therapeutic effects of small peptide, alkaloid, total flavonoids and polysaccharides extracted from sunflower plate powder on the hyperuricemia in the mice, and to clarify that the influence of sunflower powder in the uric acid (UA) level and joint swelling and its protective effect on the liver and kidney tissues. Methods: A total of 96 male Kunming rats were randomly divided into 8 groups, each group of 12 rats. One group was used as blank control group, the others were used to set up hyperuricemia models. The successful mouse models of hyperuricemia were randomly divided into model group and positive control group (allopurinol group), small molecule peptide group, alkaloi group, total flavone group, polysaccharide group and sunflower disk group. The serum UA levels were measured 7 d after administration and the liver and kidney tissues of the mice in various groups were taken. The morphological changes of liver and kidney tissues were observed by HE staining. Acute gouty arthritis model was established by injecting 3 mg sodium urate into the knee joint of the male SD rats. The experiment was divided into blank group, model group, positive control colchicine group, sunflower disc extracts (SDE) group with different concentrations (0%, 20%, 40%, 60%, 80% and 100%), 4 rats in each group. The joint circumference was measured at 0, 12, 24 and 48 h, respectively. The serum levels of interleukin-10 (IL-10) and macrophage inflammatory protein-la (MIP-la) were detected by ELISA kit. Results: Compared with model group, the serum UA levels of the mice in allopurinol group, small molecule peptide group, alkaloid group, total flavonoids group and sunflower group were significantly decreased after administration (P<0.05); and the serum UA level in allopurinol group was decreased the most, followed by small molecule peptide group. The HE staining results showed that the hepatocytes in small molecule peptide group were clear, the hepatocytes had full cytoplasm, and no abnormality was observed in the kidney cells compared with blank control group. After 48 h injection of sodium urate, the degree of joint swelling was reduced by up to 27.1% in SDE group compared with model group. Compared with model group, the serum IL-10 level in 20% SDE group was significantly increased (P<0.01), and the serum MIP-la level was also significantly increased (P<0.01). Conclusion: Sunflower powder can reduce the UA level and has protective effect on the liver and kidney tissues and it can improve the body's anti-inflammatory activity and reduce the body's inflammatory response to achieve anti-gout arthritis activity.

The article has reviewed theShengyang-Yiweidecoction for the disease of digestive system, such as diarrhea-predominant pattern irritable bowel syndrome(D-IBS), chronic gastritis, diabetic gastric paralysis (DGP), ulcerative colitis (UC) and chronic diarrhea. Recently,Shengyang-Yiwei decoction was also used in some other diseases, such as diseases of urinary system, diseases of nervous system, orthopedic diseases, gynecological diseases and so on. This review aimed to provide reference and evidence for the clinic application ofShengyang-Yiwei decoction.

Objective:To develop an evaluation index system for the management ability of general practice team leaders in community health service centers.Methods:Based on literature review, key insider interviews and other methods, the framework and indicator pool for management capability of general practice team leaders were formed. Two rounds of Delphi consultations with 15 experts were conducted from July to October 2021, and the evaluation index system of general practice team leaders' management ability established.Results:All 15 experts had at least 5 years of work experience, including 10 engaging in clinical general practice, 3 in public health and 2 in community management. The response rates for the two rounds of expert consultation was 15/15, and the expert authority coefficient was 0.84, with Kendall's W coefficient of 0.35 ( P<0.001) and 0.46 ( P<0.001), respectively. Finally, the evaluation index system of the management ability of general practice team leaders was established, which consisted of 5 primary indicators (personal quality, special business management, organizational management, teaching and research management, strategy and culture building), 11 secondary indicators and 37 tertiary indicators. Conclusions:The management capability evaluation index system general practitioner team leaders of the community health centers has been established in this stu, which may be used for the training and selection of general practice team leaders in the community health centers.

Objective:To survey on the status quo of the management capabilities of general practice team leaders in community health service centers in Shanghai.Methods:Using stratified sampling method, 18 community health service centers in the urban and suburban areas of Shanghai were selected, then the general practice team leaders and general practitioners (team members) in the centers were selected as the study participants. The questionnaire survey on the management capabilities of general practice team leaders was conducted among selected participants from November to December 2021. The self-assessment by general team leaders and the other-assessment by team members were carried out, and the total scores was calculated according to the weight of self-evaluation score (30%) and other-evaluation score(70%).Results:A total of 110 general practice team leaders and 749 team members participated in the survey. Among the team leaders, 63.64% (70/110) were females, 82.73% (91/110) were bachelor degree holders, 71.82% (79/110) had intermediate professional title, and 50.91% (56/110) worked for more than 9 h per day. The total score of general practice team leaders was (87.15±10.76) points, the other-assessment score was significantly higher than self-assessment score ((88.62±9.34) vs.(83.71±14.08), t=2.22, P<0.05). The average score of the 5 dimensions was 4.41 for special business management, 4.39 for organizational management, 4.38 for personal quality, 4.27 for teaching and research management and 4.22 for strategy and cultural construction, respectively. Conclusion:The overall management capabilities of Shanghai community general practice team leaders are at the upper-middle level, however, the capabilities in scientific research and team planning are relatively weak.

Objective:To analyze the relationship between capacity of general practice team leaders and the team performance in community health service centers.Methods:This study was a cross-sectional study. A questionnaire survey was conducted between November and December 2022, among general practice team leaders and general practitioners (GPs) from 18 community health service centers in the urban and suburban areas of shanghai selected by stratified sampling method. The personal information questionnaire, leadership of general practice team leader questionnaire,and work performance scale of general team members were used for the survey. The relationship between leadership of general practice team leaders and team performance was analyzed based on structural equation model (SEM).Results:A total of 944 questionnaires were distributed and 856 valid ones were returned with a response rate of 91.0%, including 110 general practice team leaders and 749 were GPs. The SEM analysis showed that some dimensions of the management ability of the general practice team leader had significant effect on the employee organization loyalty (organizational management: β=0.37, teaching and research management: β=-0.29, strategy and cultural construction: β=0.23, personal quality: β=0.11) and work performance (special business management: β=0.95, organizational management: β=0.54) (all P<0.05); and employee organization loyalty played a partial mediator role in relationship between leadership of general practice team leaders and work performance with a mediating effect of 39.50%. Conclusion:The management ability of the general practice team leader directly affect or indirectly affect the work performance of team members through team members′ organizational loyalty.