Sub-health is a state between healthiness and disease.It communicates with the theory of the constitution factor of traditional Chinese medicine(TCM) and the thought of preventive treatment of disease;Sub-health involves psychosomatic.It is related with TCM emotional stress,emphasizes differential diagnosis according to state of viscera as well;Complicated variety in sub-health symptom is dealt with synthetically regulation of TCM and characteristic therapy.This article discussed and analyzed the prevention and cure strategy of traditional Chinese medicine according to the characteristic of sub-health condition.

Miraculous Pivot Yin and Yang 25 Peoples plays an important role in Inner Canon of Huangdi discoursing on the typical model work of the theory of constitution categorization,it takes the theory of five elements as main lines,combines with the theory of yin and yang as the mainstay for constitution categorization.To investigate the associativity between constitution difference and constitution and disease from many latitude,and to show physical constitution is one-sided of adjust a reason,it may be said the earliest panorama of Chinese medicine physical constitution categorization.

It is of great importance that deep learning of computer for the automate identification of the two-dimensional image of Chinese herbal slices is valuable in the application to medicine,production and education.Traditional methods usually extract low-level image features for the identification,but they cannot give robust recognition results under complex backgrounds.Therefore,higher level image representation is necessary in the image identification.A public Chinese herbal medicine database was constructed with 50 common categories and 2,554 images in total,for training and evaluating our recognition model.Then,the sofimax loss function was adopted to train the convolutional neural network model.As a result,the convolutional neural network can achieve the average precision of 70％ under all the 50 medicine herbal classes.In conclusion,convolutional neural network can obtain good results in image identification with complex backgrounds and mutually occluded herbal slices,which has promising potential for future applications.

Objective To inquire into the changes of learning and memory ability and the level of SP, VIP in the brain of the model of Spleen insufficiency. To observe the influence invigorating spleen and restoring virility on above changes. Methods Establishing the spleen insufficiency model of rat by adopting bitter decline diarrhea, wild eating and overworking, to examine influence of invigorating spleen and restoring virility on the ability of learning and memory with the change of SP and VIP in the brain. Results In the period of study and remember of the water maze experiment, the swim whole distance time was long and mistake number was many in the model group; the swim whole distance time was short and the mistake number was little in the group of invigorating the Spleen and restoring virility. In the period of study and remember of the diving platform experiment, the mistake number of times is more and the incubation period was short in the model group; the mistake number was less and the incubation period was long in Spleen invigrating group. At the period of remember mistake number was more. In the model group, the immunoreaction masculine substance of SP level decrease obviously in the hypothalamus ventral kernel, the hippocampi CA1 area and forehand cortex; on above mentioned parts, the group of invigorating spleen and restoring virility increases distinctly, in the group of restoring virility increases distinctly in the hippocampi CA 1 area and forehead cortex, but decreased in hypothalamus ventral kernel. In the model group, the immunoreaction masculine substance of VIP level decreased obviously;in the hippocampi CA1 area and cortex;on above mentioned parts, the groups of invigorating spleen and restoring virility increases obviously. Conclusion In the model group, the ability of learing and memory with SP and VIP level in the brain changed. Invigorating spleen and restoring virility can improve above changes remarkably.

Objective To compare on the influence of invigorating spleen and restoring virility to the SS level and SSR1 gene expression in brain. Method The spleen insufficiency model of rat was established by adopting bitter decline diarrhea, wild eating and overworking. SS level and SSR1 gene expression change of hypothalamus ventral kernel, hippocampi CA1 area and forehead corte were detected by immunohistochemistry and in situ hybridization techniques. Result In the model group, the immunoreaction masculine substance of SS and SSR1 mRNA, hypothalamus ventral kernel, hippocampi CA1 area and forehead cortex decreased obviously. The immunoreaction masculine substance of SS and SSR1 mRNA on above mentioned parts in the group of invigorating spleen and restoring virility increased distinctly. Conclusion In the model group, the SS level and SSR1 gene expression in brain to promoting study memory ability changed. Invigorating spleen and restoring virility may affect study memory ability by regulating the SS level and SSR1 gene expression.

Objective Comparison on the influence of invigorating spleen and restoring virility to the NPY level in brain and gene expression. Method Establishing the spleen insufficiency model of rat by adopting bitter decline diarrhea, wild eating and overworking, to examine the hypothalamus ventral kernel, the hippocampi CA1 area and forehead cortex, the gene expression change of NPY. Result In the model group, the immunoreaction masculine substance of NPY, hypothalamus ventral kernel,hippocampi CA1 area and prefrontal cortex decreases obviously. The immunoreaction masculine substance of NPY on above mentioned parts in the group of invigorating spleen and restoring virility increases distinctly. In the model group, the expression of NPY mRNA on prefronta cortex and hypothalamus ventral kernel decreases obviously, while on the groups of invigorating spleen and restoring virility increases obviously. Conclusion In the model group, the NPY level and gene expression in brain to promote study memory changed. Invigorating spleen and restoring virility may affect study memory by regulating the NPY level and gene expression.

Objective To explore the lowest effective dosage of mifepristone combined with misoprostol in terminating ultra-early pregnancy.Methods All the cases of ultra-early pregnancy classified by amenorrhea days,β-hCG and vaginal B-ultrasonic were randomly divided into two groups.One hundred cases in G1 group (minimized dosage) were orally administered 25 mg mifepristone once a day for 2 days and combined with 200 μg misoprostol 48 hours later,while 150 mg mifepristone combined with 600 μg misoprostol 48 hours later were given to 100 cases in G2 group (normal dosage).All cases were observed for 6 hours after taking misoprostol and returned for assessment three days later.Results None missing.Expulsion of conceptus:G1 and G2 group were 22 (22.0％,22/100) and 25 (25.0％,25/100;P ＞ 0.05).Failure rate:cases with incomplete abortion were 1 (1.0％,1/100) and 2 (2.0％,2/100) in G1 and G2 group,hospitalization for suspected ectopic pregnancies both was 1 (1.0％).Bleeding:bleeding cases during the administration of mifepristone in G1 and G2 group were 71 (71.0％,71/100) and 78 (78.0％,78/100; P＞0.05); the mcan bleeding time were (5.3 ± 1.4) days and (6.0± 1.5) days (P ＜0.01).Other side effects:in G1 group,majority showed light nausea (7.0％,7/100) and light abdominal pain (20.0％,20/100).Menses recovery:99 (99.0％,99/100) for G1 group and 98 (98.0％,98/100) for G2 group to recovery on scheduled time.Satisfactions:both were 99 (99.0％,99/100).Except mean bleeding days and side-effects,the differences above showed no significance (P ＞ 0.05).Conclusion It is safe and effective treatment with the lowest dosages of mifepristone and misoprostol to terminate ultra-early pregnancies.

A specifically designed fiber optical spectrum system was applied to measure the hemoglobin oxygen saturation (SO2) of living rat's brain tissue. Collections of in vivo visible absorption spectrum measured by the fiber optical spectrometer at different SO2 as well as their corresponding SO2 values measured by OXImeter were made on a kind of tissue model (i. e. the mixture of Intralipid and blood) and were used as the training data of an artificial neural network (ANN) which, after being trained, can put out SO2 value correctly when an absorption spectrum was put in. The SO2 values of 5 living rats' brain tissue at different depth were obtained, and the experimental error range was +/- 5%. This method is of great significance to important value for monitoring hemoglobin oxygen saturation at various depths in brain minimally invasive surgery.
Algorithms ; Animals ; Brain ; metabolism ; Computer Simulation ; Female ; Hemoglobins ; metabolism ; Neural Networks (Computer) ; Oximetry ; methods ; Oxygen ; blood ; Rats ; Rats, Sprague-Dawley ; Spectrum Analysis ; methods

The microelectrode recordings of neuron discharge, which contain noises, are very complex and apt to be disturbed by many factors during the microelectrode-guided stereotactic operations. The varying signal-to-noise ratios are obstacles to the analysis of neural spikes. A novel method based on a combination of wavelet-based and non-linear energy operator is presented for the detection of neural spikes. The method is tested for neural signals of different patients and various SNR values. The results demonstrate its performance for successful detection and effective extraction of the waveform of neural spikes.
Action Potentials ; physiology ; Algorithms ; Humans ; Microelectrodes ; Neural Conduction ; physiology ; Neurons ; physiology ; Nonlinear Dynamics ; Signal Processing, Computer-Assisted

Currently, the intraoperative location of microelectrode position in the globus pallidus is subjective and qualitative; it only depends on the experience of doctors during pallidotomy for the treatment of Parkinson's disease. The fractal characteristic of neuronal discharge signals is analyzed for target localization; the factor of box dimension is extracted from the microelectrode recordings for identifying the neuronal structures at the depth of microelectrode. New objective and quantitative targeting technique is presented by processing clinical microelelctrode recordings of Parkinson's disease. Through the validation of clinical data and the critical appraisal by experts, the targeting technique can be used for improving the accuracy of localization in neurosurgery.
Electrophysiology ; Globus Pallidus ; physiopathology ; surgery ; Humans ; Microelectrodes ; Neurons ; physiology ; Pallidotomy ; methods ; Parkinson Disease ; physiopathology ; surgery ; Stereotaxic Techniques ; Surgery, Computer-Assisted ; methods