In this paper, acute nonlyumphocytic leukemia that is not fit for strong chemotherapy treated with low dose cytosine arabinoside (Ara—c) in 11 cases is presented. One of the patients got a complete remission and another was partial remiss, the total remission rate being 18.2%. The therapeutic mechanism, side effect, and remission rate of low dose Ara-c have been discussed. The authors conclude that this treatment is still of choice to the patients who are not fit for strong chemotherapy.

目的观察综合疗法治疗小儿脑瘫的临床疗效。方法150例脑瘫患儿随机分为针刺组50例(采用针刺疗法)、康复组50例(用现代康复疗法)、综合组50例(采用针刺结合康复疗法),3个月后比较各组的疗效。结果综合组治疗前后日常生活活动能力(ADL)差值明显高于针刺组和康复组(P<0.01);综合组和康复组治疗后的爬行能力均较治疗前有显著性差异(P<0.05),针刺组无显著性差异(P>0.05),综合组和康复组治疗后的爬行能力与针刺组有显著性差异(P<0.01),但综合组和康复组之间无显著性差异。结论综合疗法是治疗脑瘫的有效方法,可提高患儿的ADL和爬行能力。

BACKGROUND: The psychological researches on undergraduates popularly believe that status of mental health of undergraduates can be worried.OBJECTIVE: To investigate the relationship between personality and mental health of undergraduates in Henan province, and analyze the feasible value of developing mental health education effectively.DESIGN: Sampling investigation.SETTING: Department of Health Administration, Henan Medical College for Staff and WorkersPARTICIPANTS: 1 128 students from 3 university and colleges in Henan province, whose majors were agriculture, medical science, sciences,literal arts, arts and physical education, etc., were enrolled randomly in this study between April and June 2001.METHODS: Group test was performed in 1 128 students from higher learning schools of Henan province test with Eysenck Personality Questionnaire (EPQ) [including 4 dimensions: Extraversion (E), Neuroticism (N),Psychoticism (P), and Social Desirability (L)] and Symptom Checklist90(SCL-90) (90 items, 9 dimensions).MAIN OUTCOME MEASURES: ① Comparison of personality characteristics between undergraduates and national norms. ② Classified comparison of personality characteristics of undergraduates. ③ Relationship between personality characteristics and mental health of undergraduates.RESULTS: Incomplete questionnaires were excluded, and 1 100 qualified questionnaires were collected. ① Comparison of personality between undergraduates and national norms: Scores on N and L of EPQ in male undergraduates were higher significantly than those of the national norms (5.47 ±3.13,4.53 ±3.11 ;4.99 ±2.47,4.50 ±2.59,P ＜ 0.001 ).Scores on N, P and L of EPQ in female undergraduates were all higher remarkably than those of the national norms (2.97±1.71,2.68±1.82;5.68±3.08,4.97±2.96;5.32±2.46,4.74±2.48,P ＜ 0.05-0.001). ②Classified comparison of personality in undergraduates: There were obvious differences on the 4 dimensions of EPQ in students of 6 different specialties (P ＜ 0.05-0.001 ). Scores on P in agricultural students were the highest (3.44±1.97); Scores on E in students of physical education were the highest (8.27±2.45), while scores on N in literate arts students were highest (5.99±3.24). Male students'scores on L were lower markedly than female students'(4.99±2.47,5.32±2.46,P ＜ 0.05).Scores on E in students from cities were lower significantly than those in students from countrysides (7.54±2.73,7.93±2.63,P ＜ 0.05). Between lower grade (freshman year and sophomore year) and higher grade (junior year and senior year), only scores on L in the former were high er significantly than those in the latter (5.42±2.44,5.01±2.48,P ＜ 0.01 ).Moreover, scores on E in student cadres were higher apparently thanthose in non-student cadres (8.42±2.61,7.42±2.68,P ＜ 0.001). ③Relationship of personality and mental health in undergraduates: E and L of personality dimension in undergraduates had obviously negative correlation with every factor of SCL-90 (P ＜ 0.01-0.001 )while N had significant positive correlation with every factor of SCL90 (P ＜ 0.001),and P had significant positive correlation with somatization, hostility,phobic anxiety and paranoid ideation (P ＜ 0.05-0.01 ).CONCLUSION: Personality of undergraduates have extremely close internal correlation with their mental health. Introversion, emotional instability and psychoticism of personality of undergraduates have side effects on their psychological health. There are some differences of personality characteristics in different specialty, sex, grade, native place (city or countryside),cadre or non-cadre students.

BACKGROUND: Cancer stem cell is a minority population of cancer cells in multiple myeloma possessing the properties of stem cells: self-renewal, multi-directional differentiation and long-term proliferation, which mediating disease initiation, relapse, progression and drug resistance.OBJECTIVE: To review characteristics of biology, phenotypic analyses, sorting and identification in clonogenic myeloma cells, the signaling pathways with in myeloma stem cells and the target therapy related.METHODS: Application of computer search Medline database (1999-01/2009-04), using "multiple myeloma stem cells, heterogeneity, phenotypic analysis, signaling pathways, target therapy" as key words; application of computer search CNKI database (1999-01/2009-04) and CBM Database (1999-01/2009-04) using "multiple myeloma stem cells, heterogeneity, stem cell separation and identification, signal transduction, targeted therapy as key words".RESULTS AND CONCLUSION: We collected for 126 literatures on the multiple myeloma stem cell-related, which include 30 Chinese articles and 96 English articles, excluding published earlier, repeated, and similar studies into 30 sub-standard literatures. Now widely recognized that multiple myeloma stem cells may be derived from normal stem cells, the accumulation of mutations and by gene mutation in regaining self-renewal capacity of progenitor cells or fully differentiated mature cells. Circulating clonotypic memory B-cell populations have self-renewal and multi-directional differentiation potential, which represent the cancer stem cells in multiple myeloma. The exact phenotype of multiple myeloma cancer stem cells has not been definitively established and researched remains. At present, both the side population cells and aldehyde dehydrogenase (ALDH) activity assays were mainly capable of isolating multiple myeloma cancer stem cells. Which to possess self-renewal ability by Hedgehog ,Wnt and Notch signaling pathways. When these signal transduction pathways appear abnormal, leading to the occurrence of the tumor and tumor cell growth in non-controlled. Against the cancer stem cell targeted therapy is a new and important direction of selective therapeutic strategies. Cancer stem cell specific surface markers and signal transduction pathways can be used as anti-cancer stem cells to control tumor development targets.

ObjectiveTo study the feasibility and reasonability of low-dose multi-slice CT(MSCT)with three dimensional rendering of the tendons of foot and ankle. The statistical methods including ANOVA and Kruskal-Wallis H was used. MethodsForty-five consecutive patients with fractures of foot and ankle were enrolled and evenly grouped into A (80 kV, 100 mAs), B(110 k V ,60 mAs) and C (130 kV,60 mAs).The MSCT scanning range was 6 slices of 1.0 mm. The CT value and standard deviation (SD) of the muscle and the CTDIvol were recorded. The image quality of volume rendering of the tendons was blindly evaluated.ResultsThe CT value of muscle in group A (71.6 ± 12.0) HU was significantly higher than group B [(66.8±9.2) HU, P=0.010]and C[(66. 1 ±7. 1) HU, P =0.004]. The SD average values were 11.9, 6. 1 and 7.0 HU for three groups, and there were significant differences among the three groups(F =37. 142, P=0. 0000). Group A had the highest SD value, group C had the lowest SD;CT1DIvol average value were (3.01 ± 0. 08) , (4. 63 ± 0. 11), (7.02 ± 0. 24) mGy respectively, which were significant different among the three groups (H =39. 185, P =0. 000). Group A had the lowest CTDIvol, while group C had the highest CTDIvol. Volume rendering of the tendons was evaluated as 2.3 ± 0. 5、3.7 ± 0. 5、4. 8 ±0. 4, and there were significant differences among the three groups (H = 72. 779, P = 0. 000). Group A had the worst VR images, while group C had the best VR images.All VR images in Group B were good for diagnosis. ConclusionThe protocol of 110 kV, 60 mAs, and 1 mm × 6 with three-dimensional volume rendering would be enough for evaluating the tendons of foot and ankle.

The difference between absorption of unfractionated heparin (UFH) and low molecular weight heparin (LMWH) after oral and oral cavity administration were studied respectively, and the compatible enhancer for oral cavity delivery system of both drugs was found. The LMWH and UFH films were prepared with two bioadhesive materials Carbopol and alginate sodium for oral cavity delivery. The activated partial thromboplastin time (APTT) was used to determine LMWH and UFH in plasma after oral, oral cavity and sc administration in rats. The results show that the enhancer (Labrasol) can increase the absorption of LMWH and UFH through oral cavity in rats but not obviously. The oral cavity iontophoretic delivery system is a useful method to improve the absorption of LMWH and UFH through oral cavity mucosa.

Objective: To develop a HPLC method for the content and uniformity of dosage units of dehydroandrographolide in Xiaoyanlidan Tablets. Methods: ODS column was used and methanol water (70∶30) was used as a mobile phase. The detection wavelength was set at 250nm. Results: The linear range was from 2.14 to 34.24?g/mL (r =0.9999). The average recovery was 99.91%, and the relative standard deviation was 1.78%. Conclusion: The method is convenient and accurate.

Acupuncture, Tuina and combination of acupuncture and Tuina were used to treat 250 cases of shoulder periarthritis who were randomly divided into three groups. Bingfeng (SI 12) and Ashi points were selected and cupping therapy was also given following acupuncture in acupuncture group; pressing, kneading and plucking manipulations were performed in Tuina group,acupuncture plus Tuina were employed in group of acupuncture plus Tuina. The therapeutic results showed acupuncture plus Tuina was better than simple Tuina, and statistical analyses demonstrated P ＜0.05.

Objective To establish a method for the quality control of Huox ia ng Zhengqi Capsules(HZC). Methods Radix Angelicae Dahuricae, Herba Pogostemo nis, Pericarpium Citri Reticulatae and Rhizoma Atractylodis Macrocephalae in HZ C were identified by TLC. The content of magnolol and honokiol were determined b y HPLC. The chromatographic conditions were: Diamonsil C18 (250 mm? 4.6 mm, 5 ? m) column, mobile phase being methanol- acetonitrile- water (20 ∶ 15 ∶ 9 ), and the detection wavelength at 294 nm.Results The qualitative identificat ion with TLC was specific. The linear ranges of magnolol and honokiol were 16.14 4～ 80.72 ? g/mL (r=0.9998) and 20.48～ 102.40 ? g/mL( r=0.9997) , the avera ge recovery were 97.07 % and 97.89 % and RSD were 1.17 % and 1.06 % resp ectively. Conclusion This method is sensitive, stable and accurate. It can be used for the quality control of HZC.

AIM: To investigate the effects of puerarin on expression and translocation of glucose transporter 4(GLUT4) in adipocyte of rats with insulin resistance induced by diets. METHODS: Experimental rats were divided into three groups: control group (n=10), model group (n=10) and puerarin group (n=10) randomly. Animals in model group and puerarin group were fed with the diets enriched with sucrose (20%, w/w), lard (10%, w/w), cholesterol( 2.5%, w/w) and cholic acid (1%, w/w) to induce insulin resistance. Puerarin group were treated with puerarin (100 mg?kg -1 body weight, ip) every day for 6 weeks. After the plasma membranes and the intracellular membranes of adipocyte were prepared and separated, GLUT4 protein was detected by Western blot analysis. Body weight, serum triglyceride and cholesterol, fasting plasma glucose and serum insulin concentration were detected termly. And the insulin sensitivity index was also calculated. RESULTS: Western blot analysis showed that intracellular membranes GLUT4 protein in adipocyte of model group rats decreased by 38.72% (P