The growth and metastasis of tumor relies on oxygen and nutrients provided by neonatal blood vessel. When no angiogenesis, the tumor growth will be obviously inhibited. At present, anti-tumor angiogenesis strategies are increasingly becoming a focus of attention and study at home and abroad. However,because of the complexity of the antiangiogenesis, the clinical effects of antiangiogenesis alone is not so satisfied, while this is reversed when combined with radiotherapy.

There are many causes of children cerebral infarction, including cerebrovascular malformation,autoimmune cerebrovascular phlogistic, infection, trauma and the high state of blood coagulation. Because the brain development is not mature, the children is the high-risk group of traumatic cerebral infarction. The early diagnosis of traumatic cerebral infarctions relies on the dynamic performance of the clinical observation, taking head CT or MRI quickly, especially diffusion-weighted imaging, which is more sensitive on the judgement of acute cerebral infarction period. Common sites of traumatic cerebral infarction are basal ganglia. The infarcts are usually small. Treatment on traumatic cerebral infarction must give priority to non-operation. Early diagnosis and prompt treatment can provide better prognosis than adults.

Objective To investigate the risk factors of pneumonia associated to elderly patients with cerebral stroke.Methods Totally 248 elderly patients with stroke were retrospectively analyzed on medical history,treatment and prognosis.Results In 248 cases of senile stroke patients,78 cases had an associated pneumonia,accounting for 31.5％.The onset with admission period ≥48 h was in majority (48 cases),less than 48 h in 30 cases (38.5％).12 patients (15.4％)were involved blood culture,38 cases sputum culture,accounting for 48.7％.In the univariate correlation analysis,older age,consciousness,basic diseases,stroke location,NIHSS score of nasal feeding therapy were associated with associated pneumonia (all P＜0.05).As compared to patients without no associated pneumonia,the patients with associated pneumonia had more aged and higher proportions of bulbar paralysis and impaired consciousness,more underlying diseases.At the time of admission,increased occurrences of National Institute of Health Stroke Scale (NIHSS) score,brainstem stroke and multiple feeding treatment appeared in most of patients.Multivariate Logtistic regression analysis showed that age≥ 65 years,history of pulmonary disease,bulbar paralysis,disturbance of consciousness,nasal treatment among older stroke were the associated pneumonia risk factors.The hospitalized time was prolonged [(31.3±20.4)d and(17.6±8.1)d,t＝7.57,P＝0.001] and fatality rate increased (41.0％ vs.4.1％) in patients with pneumonia than without pneumonia(x2＝ 54.96,P＝ 0.000).The independent factors of death were aged ≥ 75 years(OR＝1.6,95％CI:1.0-2.6),NIHSS＞13 (OR＝5.0,95％CI:1.7-24.6) and pulmonary infection(OR＝5.2,95％ CI:1.8-17.3).Conclusions The occurrence of associated pneumonia in elderly patients with cerebral stroke is related with age,underlying disease,state of consciousness and NIHSS scores.The prevention and treatment of relevant factors can improve prognosis.

Objective To discuss the influence of atorvastatin and rosuvastatin on carotid intima-media thickness(CIMT) of patients after percutaneous coronary intervention (PCI).Methods 142 patients after PCI with CIMT increasing were randomly divided into Lipitor group (n=71) and Crest group (n=71).The Lipitor group was given atorvastatin(20mg) orally once a day.The Crest group was given rosuvastatin(20mg) orally once a day.The changes of low density lipoprotein,high density lipoprotein,liver function and CIMT before and after 12 weeks treat-ment were observed in two groups.Results After treatment for 6 months, the levels of LDL-C, CIMT in Lipitor group were lower than before treatment with statistical difference[(3.37 ±1.20)mmol/L vs (2.0 ±0.29)mmol/L, (1.29 ±0.06)mm vs (0.91 ±0.23)mm](t=4.032,3.523,all P<0.05);the levels of LDL-C,CIMT in Crest group were lower than before treatment with statistical difference[(3.38 ±1.21)mmol/L vs (1.8 ±0.15)mmol/L, (1.30 ±0.16)mm vs (0.81 ±0.15)mm](t=4.700,3.892,all P<0.05).The decreasing degree of LDL-C, CIMT was significantly lower in Crest group than that in Lipitor group with statistical difference( t=3.668,3.002,all P<0.05 ) .The level of HDL -C in Lipitor group was higher than before treatment with statistical difference [(1.01 ±0.36)mmol/L vs (1.10 ±0.31)mmol/L](t=3.801,P<0.05).The level of HDL-C in Crest group was higher than before treatment with statistical difference[(1.03 ±0.32)mmol/L vs (1.15 ±0.35)mmol/L](t =3.722,P<0.05).The decrease degree of HDL-C was significantly higher in Crest group than that in Lipitor group with statistical difference(t=3.568,P<0.05).Conclusion Rosuvastatin has better effect than atorvastatin on the reversal of atherosclerosis process.

In the recent years, with the improvement of conditioning regimens, the prevalence of high-resolution HLA matching, as well as the application of high-intensity broad-spectrum antibiotics, unrelated donor transplantation for the treatment of severe aplastic anemia has been improved significantly, with lower incidences of graft failure, graft-versus-host disease, infectious complications, etc. Studies have already confirmed that transplantation from an unrelated donor should be recommended as an effective therapy for children and young adults who do not respond to the first course of immunosuppressive therapy.

Stress response is an organism's defense mechanism against various stimulations, and involves nervous, endocrine, cardiovascular and immune systems.This review summarized the clinical research progress of adjuvant anesthetics and methods for reducing stress response and future trends of investigation.

Objective To understand the status of the disease in local population and the fluoride content in drinking water in the endemic areas of endemic fluorosis in Etuoke Banner of Inner Mongolia,and to provide a scientific basis for making strategies in prevention and control of the disease.Methods Totally 100 endemic fluorosis villages were selected as survey sites,to study the progress and effect of water-improving and defluoridation projects in Etuoke Banner in 2015.In monitoring villages with improved water,1 water sample from the tap water was collected to determine the fluoride level,and in water unimproved villages,1 water sample from each direction of the east,south,west,north and middle of the villages was collected,respectively,to determine fluoride level.Dental fluorosis of children aged 8 to 12 was examined in each village.Water fluoride was tested according to the Standard Testing Methods for Drinking Water (GB/T 5750.5-2006).Diagnosis of dental fluorosis was based on the Diagnostic Criteria for Dental Fluorosis (WS/T 208-2011).Results A total of 100 diseased villages were investigate,the water-improving rate was 39.00％ (39/100).Among the 39 water-improving projects,normal operating rate was 66.67％ (26/39),intermittent operating rate was 15.38％ (6/39) and scrapped projects accounted for 17.95％ (7/39);the qualified rate of water fluoride projects was 53.85％ (21/39).A total of 268 tap water samples were collected,the mean of water fluoride was 1.39 mg/L,and the range was 0.22-5.57 mg/L.In the 61 waterunimproved villages,the water fluoride level ＞ 1.2 mg/L in the drinking water accounted for 49.18％ (30/61),covering a population of 5 231 people.The water fluoride level ＞ 2.0-4.0 mg/L in the drinking water accounted for 18.03％ (11/61),covering a population of 2 326 people;the number of village with water fluoride level ＞ 4.0 mg/L was 1,accounted for 1.64％ (1/61),covering a population of 162 people.A total of 1 040 children aged 8 to 12 in the survey villages were examined,the total rate of dental fluorosis was 9.71％ (101/1 040),the index of dental fluorosis was 0.18,and the prevalence was negative.Conclusion The water-improving and defluoridation projects in Etuoke Banner,Inner Mongolia has a certain effect on children's dental fluorosis,but water fluoride content has exceeded the standard significantly,the water improvement measures should be further strengthened.

the education the education of appreciate the beauty is a kind of character education,.And the character of a kind of spirit level of structure the education.It can educate what medical science living to appreciate beauty the ability,and affect the medical science the concept of value that living,and increase the medical science the human life state that living,and educate the medical science the creation thought that living.this article basic of medical science history teaching to discuss how foster the students to appreciate the beauty of the education.

OBJECTIVE:To investigate the effects of water extract of Panax quinque folium(WEAG,of cool property)and Panax ginseng(WERG,of warm property)on MPP+-induced apoptosis of SH-SY5Y cells.METHODS:SH-SY5Y cells were divided into 4 groups:the control group was cultured in complete medium,model group was cultured with 0.5 mmol MPP+;Panax quinque folium group was treated with 0.5 mmol MPP+ plus different concentration of WEAG,and Panax ginseng group was treated with 0.5 mmol MPP+ and different concentration of WERG concomitantly.WEAG and WERG were added for intervention.the morphology of SH-SY5Y cells was observed by Hoechst33258 staining and the apoptotic rate was detected by FCM;the cell survival rate was measured by MTT chromatometry.RESULTS:Compared with model group,WEAG and WERG markedly reversed the apoptotic characteristics of SH-SY5Y cells,markedly up-regulated MTT value and lowered the apoptotic rate,with WERG showing more potent efficacy than WEAG doing.CONCLUSION:Water extracts of both Panax quinque folium(cool)and Panax ginseng(warm)pose protective effects of different degree against MPP+-induced apoptosis of SH-SY5Y cells,with the Chinese materia medica of warm property showing more potent action against apoptosis.Chinese materia medicas of different drug property have different anti-apoptotic action.

OBJECTIVE:To investigate the effects of water extracts of Panax ginseng(warm),dry P.ginseng(mild),P.quinque folium(cool) on the apoptosis of SH-SY5Y cells induced by ?-amyloid protein(A?25-35).METHODS:SH-SY5Y cells were treated with A?25-35 to simulate the pathologic neuronic damage model in patients with Alzheimer's disease,and then treated with different doses of water extracts of P.ginseng(WERG),dry P.ginseng(WEG)or P.quinque folium(WEAG).The morphologic changes of the SH-SY5Y cells were observed by inverted microscope.Cell survival rate was measured by MTT assay.The percentage of apoptosis and the expression of Bax and Bcl-2 proteins were detected by Western Blotting.RESULTS: After treatment with A?25-35 50 ?mol?L-1 for 72 hours,SH-SY5Y cells became more round and aggregated and the cell survival rate was significantly reduced(P