Objective:To observe the effect of Aalv Capsule on sodium current in guinea pig ventricular myocytes(INa)for exploring the mechanism of its anti-premature beats.Methods:Whole-cell patch-clamp recording technique was used to record the Aalv Capsule for a single cell of sodium currents in guinea pig ventricular myocytes.Results:There was dose-dependent of Aalv Capsule in block of sodium currents and had a certain amount of use-dependent and time-dependent.Conclusion:The role of Aalv Capsule in blocking sodium current block was one of the mechanisms of its in bearing premature.

Objective To translate the English version of Infant Feeding & Nutrition Checklist For Congenital Heart Disease (IFNC:CHD) into Chinese,and to test the reliability and validity of the Chinese version of IFNC:CHD.Methods After obtaining authorization from the developer,the IFNC:CHD was translated and culturally adapted into Chinese version.The reliability and validity of the Chinese version of IFNC:CHD were tested in 168 patients.Results The Cronbach's α coefficient was 0.804.Two nurses used the scale to evaluate the consistency of the results,and the Kappa coefficient was 0.812.The content validity index of item ranged from 0.80 to 1.00,and the average index was 0.90 for the total scale.The correlations coefficients between each dimension score and the total score ranged from 0.339 to 0.474 (P＜0.01),and the correlations coefficients between each dimension score ranged from 0.198 to 0.861(P＜0.01,P＜0.05),Three factors were extracted from exploratory factor analysis,and the cumulative variance contribution rate was 72.66％.Conclusion The Chinese version of IFNC:CHD has been proved to have good reliability and validity.It can be used to assess infant feeding and nutritional risk of congenital heart disease in the Chinese settings.

Objective Toexplorethecorrelationanalysisofmammographyandclinicalcharacteristicsassociatedwiththerecurrence ofearlystageoftripleGnegativebreastcancer(TNBC).Methods Thedataofmammographyandclinicalcharacteristicsof231TNBC patientsfromJanuary2009to October2017 wereretrospectivelyanalyzed,andthenthedifferencesofmammographyandclinical characteristicswerecomparedbetweenthepatientswithrecurrence(n＝64)andthosewithoutrecurrence(n＝167).Results Compared withthepatientswithoutrecurrence,thepresenceoffamilyhistoryinpatientswithrecurrencewashigherthanthosewithoutrecurrence (12.5%vs3.6%,P＜0.05).Thehistologicalgradesofthepatientswithrecurrenceweremainlyshowedasgrade2(6.3%)and3(93.7%), andthehistologicalgradeinpatientswithrecurrencewashigherthanthosewithoutrecurrence(P＜0.05).Themammographicfindingsin TNBCshowedthatthepatientswithrecurrenceweremorelikelytohavedensebreasttissue(84.4%),axillarylymphnodesinvasion (53.1%)andlowercalcification(12.5%)(P＜0.05).Multivariatelogisticregressionanalysisshowedthatthefamilyhistoryofbreast cancer(P＝0.01,OR＝2.54),histologicalgradeof2(P＝0.01,OR＝2.23)and3(P＜0.001,OR＝3.79),mammographicdensity breasttissue(P＝0.02,OR＝2.32),calcification(P＝0.02,OR＝0.45),andaxillarylymphnodesinvasion(P＝0.03,OR＝1.75)were statisticallysignificancewithTNBCrecurrence.Conclusion Thefamilyhistory,histologicalgrade,thepresenceofdensebreasttissue andaxillarylymphnodesinvasionsatmammographywereassociatedwiththeincreasedriskofrecurrenceinTNBC,whilethepresenceof calcificationwasrelatedtothelowerriskofrecurrenceinTNBC.

OBJECTIVE:To investigate the development of related TCM evidence-based researches in China.METHODS:The literatures titled"Meta-analysis"and those with Chinese Library Classification Number of"R2(Chinese Medicine)"were searched from CJFD by computer. The retrieval time limit ranged from database establishment to Dec. 2017. Bibliometrics analysis was performed in respects of year of publication,source journals,publishers,authors,co-authors,funding and research content. RESULTS:A total of 1 540 papers from 321 journals were included,and the first paper was published in 1997;the first author came from 494 institutions which mainly distributed within the mainland institations of China. Guangzhou University of TCM had the largest number of publications. According to Price's law,there were 25 core authors who published 157 literature in total;the co-authoring rate was 95.1% and the collaborating degree was 4.00. 32.3% of the papers were obtained by the fund support, involving 236 literatured founded by National Science Foundation of China. There were 5 types of papers,including 1 512 applied research papers,14 quality evaluation papers,6 methodological studies;there were 17 categories of diseases involved in applied research. CONCLUSIONS:Meta-analysis of TCM research in China has developed rapidly,but related theoretical research is relatively lack. It is necessary to further strengthen the methodology research so as to promote the development of evidence-based research of TCM.

Objective:To evaluate the effectiveness and safety of preemptive nasogastric tube placement for improving nutritional status and clinical outcomes in hospitalized infants with congenital heart disease.Methods:Children from 0 to 12 months with congenital heart disease hospitalized in cardiovascular center of Children's Hospital of Fudan University from February to July 2018 were selected as control group through continuous sampling. Children hospitalized were selected from September 2018 to February 2019 as intervention group. The control group followed the current feeding method, the intervention group used preemptive nasogastric tube placement. The nutritional indicators, feeding indicators and clinical outcomes of the two groups were compared to evaluate the intervention effect.Results:The serum albumin and prealbumin of the children in the intervention group were (36.81±4.59) g/L and (162.74±48.17) g/L, which were higher than those in the control group (34.80±5.21) g/L and (142.98± 33.96) g/L, the difference between the two groups was statistically significant ( t values were -2.721, -3.169, both P<0.05); the daily enteral intake, calorie intake and single enteral calorie intake of children in the intervention group were (124.93±27.97) ml·kg -1·d -1, (376.48±88.53) kj·kg -1·d -1, (48.39±9.13) kj·kg -1·time -1, higher than the control group (114.74±30.63) ml·kg -1·d -1, (330.01±90.75) kj·kg -1·d -1, (44.24±13.31) kj·kg -1·time -1, the difference between the two groups was statistically significant ( t values were -2.511, -3.750, -2.382, all P<0.05). the incidence of feeding difficulties in the intervention group was 4.95% (5/101) lower than 14.68% (16/109) of the control group, the difference between the two groups was statistically significant ( χ2 value was 5.513, P<0.05); the proportion of children in the intervention group reaching the target feeding amount when discharged from the hospital was 97.03% (98/101), higher than 84.40% (92/109) of the control group, the difference between the two groups was statistically significant ( χ2 value was 9.699, P<0.05). Conclusions:Preemptive nasogastric tube placement is safety and effectively for patients with congenital heart disease in clinical infants. but it still needs a large sample for a long time to confirm its effectiveness.

Objective:To explore the efficacy of venetoclax plus azacitidine (VA) in the treatment of patients with newly diagnosed chronic myelomonocytic leukemia (CMML).Methods:The clinical data of 4 newly diagnosed CMML-2 patients treated with VA regimen in the Affiliated Hospital of Hebei University from February 2022 to March 2023 were retrospectively analyzed, and the related literature was reviewed.Results:All 4 CMML-2 patients achieved the effect of ≥ partial bone marrow remission (PMR) after 1 course of treatment, and with the deepened extension of treatment course, the overall response rate and complete remission (CR) rate was 100% and 50%, respectively. In terms of dose adjustment, the dose and usage day of venetoclax were determined by using dynamic frailty assessment and adverse events. Among the 2 patients who achieved CR, 1 patient initially received venetoclax 200 mg for 14 days, and 1 patient received venetoclax 400 mg for 28 days and then the usage reduced to venetoclax 200 mg for 14 days due to hematological adverse events. All 4 patients maintained CR status. The most common grade 3 and 4 adverse events were neutropenia and thrombocytopenia.Conclusions:The first-line application of VA regimen in the treatment of newly diagnosed CMML-2 patients may achieve faster remission and better safety compared with traditional HMA monotherapy.

Objective To explore the effects of behavioral activation (BA) intervention on patients with chronic obstructive pulmonary disease (COPD) complicated with anxiety and depression. Methods Totally 70 patients with COPD complicated with anxiety and depression who were hospitalized in a ClassⅢ Grade A hospital from August 2018 to April 2019 were selected using convenient sampling and divided into experimental (n=35) and control (n=35) groups according to the time of admission. Patients in the control group received conventional hospital care and psychological guidance in the Department of Respiratory Medicine, while patients in the experimental group received BA intervention on this basis. Anxiety, depression and fatigue scores were compared between the two groups. Results A total of 33 patients in control group and 32 patient in experimental group completed the study. After BA intervention, the anxiety and depression scores of the experimental group were lower than those of the control group, and there were statistically significant differences between the two groups (P＜0.05). The total score of multi-dimensional fatigue scale of COPD patients in the experimental group was lower than that of the control group, the difference was statistically (P＜ 0.05), and there was no statistically significant difference in the score of mental fatigue between the two groups (P＞0.05). Conclusions BA intervention can ameliorate the anxiety and depression in patients and reduce their sense of fatigue, thus improving their quality of life.

Objective:To build an evaluation index system for the post competency of nurses in Kidney Intensive Care Unit (KICU) , so as to provide references for the post access management and training system setting of KICU nurses.Methods:Through literature review and semi-structured interview, the post competency evaluation index system of nurses in KICU was preliminarily constructed. Using the purposive sampling method, a total of 15 nursing experts were selected for 2 rounds of expert letter consultation from March to June 2021, and the indicators at all levels were screened, revised and improved. The evaluation index system for the post competency of nurses in KICU was established.Results:The effective recovery rates of the two rounds of questionnaires were both 100.00% (15/15) , the expert authority coefficients were respectively 0.85 and 0.87 and the Kendall harmony coefficients of total indicators were respectively 0.332 and 0.341 ( P<0.01) . The final evaluation index system of post competency of nurse in KICU included 4 first-level indicators, 16 second-level indicators and 51 third-level indicators. Conclusions:The constructed evaluation index system of post competency for KICU nurses is scientific and reliable, which can provide references for the post access management and training system setting of KICU nurses.

Objective:To explore the prevalence and risk factors of cardiac events in different ethnic groups in Xinjiang region.Methods:This retrospective cohort study was based on big data from the health checkup population. A total of 7 899 cases were included from the Physical Examination Center of Xinjiang Uygur Autonomous Region People′s Hospital form 2015 January 1 to December 31, 2017.The population were divided into Uyghur group (2 630 cases), Kazak group (2 636 cases), and the Han nationality group (2 633 cases). Telephone follow-up was conducted once a month after the health checkup, the preset follow-up time for all personnel was 2 years, with the occurrence of cardiac events as the end point. Once cardiac events occurred, the follow-up would be stopped. The risk factors of cardiac events in different ethnic groups were evaluated by statistical analysis.Results:The median follow-up time of the 7 899 included healthy examinees was 1.27 years, and 200 cases of cardiac events occurred, with an incidence rate of 2.53%. The values of body mass index (BMI), the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of Uyghur and Kazak were higher than those of Han (all P<0.05). The cardiac events in Uyghur, Kazak and Han group were 75 cases (2.85%), 85 cases (3.22%) and 40 cases (1.52%). There was no significantly statistical difference between Uyghur group and Kazak group in the incidence of cardiac events, while it was significantly lower in the Han group than the other two groups (both P<0.05). Univariate analysis showed that BMI, TC, TG, HDL-C and LDL-C were the risk factors of cardiac events; multivariate Cox regression analysis showed that ethnic groups ( HR=4.34, 95% CI: 1.14―8.13); HDL-C ( HR=3.32, 95% CI: 1.89―5.74) and LDL-C ( HR=2.47, 95% CI: 1.21―7.45) were independent risk factors for cardiac events. Conclusions:Ethnic factor is one of the independent risk factors for the occurrence of cardiac events in Xinjiang, and Uyghur and Kazak have a higher incidence of cardiac events. HDL-C and LDL-C are also important risk factors for cardiac events.

Objective To examine the development of traditional Chinese medicine (TCM) in China and provide reference for the construction of a discipline through a literature review of TCM physique and statistical analyses of papers published between 2008 and 2017. Methods We searched the Chinese journal full?text database for TCM physique research papers, and used bibliometrics to statistically analyze the papers. Results We obtained 2 905 papers from 381 journals, 1 021 institutions, and 6 740 authors. The number of papers increases with the publication time. The cited rate was 87.2%. Each paper was cited 8.74 times. The H?index was 51 and co?authored rate was 83.7%. The cooperation degree was 3.78 with 3 354 words appearing in the keywords of the papers. Conclusion In the past ten years, research on TCM constitution has advanced, strengthening core scientific research. Research quality is high, and the research contents cover a wide range. With the spread of research tentacles, the prospect of further research on this subject is worth looking forward to.