Objective To evaluate the therapeutic effects of bi-level positive airway pressure on acute left heart failure. Methods Thirty patients with acute left heart failure received combined conventional therapy and bilevel positive airway pressure, and were compared with 30 patients with acute left heart failure receiving traditional treatment as controls. The changes in the power of hydrogen, partial pressure of oxygen in artery, pulse oxygen saturation,partial pressure of carbondioxide in artery,buffuer excess,blood pressure,heart rate,and breathing frequency,and clinical symptom were compared between the two groups. Results Compared with control group,the blood pressure,heart rate, breathing frequency decreased significantly( P＜0. 05 ) ;pulse oxygen saturation increased significantly (P＜0. 05 ) ; the power of hydrogen, partial pressure of oxygen in artery, partial pressure of carbondioxide in artery, and buffuer excess were improved more significantly ( P＜0. 05 ) ; the marked response rate and the total effective rate increased significantly(P＜0. 05). Conclusion The combined conventional therapy and bi-level positive airway pressure has a good efficacy in the patients with acute left heart failure.

OBJECTIVE To evaluate the medical instrument′s cleaning effect and bacterial elimination result by using multi-enzyme cleaning agent.METHODS The total 229 pieces of moderate contaminated medical instrument were randomly divided into 2 groups:control group and experiment group.The effects after routine water immersion and processing of multi-enzyme cleaning(including hand cleaning and machineone were observed and the bacteriological examination in the sample was checked.RESULTS 96% of the medical instruments in experiment group were cleaned,while only 35% of them in control group were cleaned.It was showed the cleaning effect of multi-enzyme was better than routine water immersion.In the experiment group,the contaminated rates of blood pincers and tweezers after hand cleaning with multi-enzyme were 33.7% and 25.5%,respectively,while the contaminated rates of blood pincers and tweezers after machine cleaning with multi-enzyme were 0.It indicated that the bacterial eliminate rate of machine cleaning with multi-enzyme was higher than hand cleaning with multi-enzyme.CONCLUSIONS Multi-enzyme agents are better for medical instrument cleaning.

This paper reports the nursing care of 7 patients with liver cirrhosis during pregnancy and childbirth. During the pregnancy period,nursing care focused on integrated management,monitoring of the dynamic changes of liver cirrhosis and individualized care. During delivery and perioperative period,supportive treatment was implemented and complications such as upper gastrointestinal hemorrhage,postpartum hemorrhage and infections were prevented. The 7 patients got through the perinatal period safely.

Objective: Our study described the body composition of 50 preschool children aged from 4 to 6 years old and evaluated their nutritional and developing status. Methods: Body composition was measured with dual energy X ray absorptiometry(DXA). Results: BMC, BMD, FTM, %BF, LTM of all children were (463.3?80.9)g、(0.69?0.04)g/cm 2、(3917.1?1281.6)g、(21.8?4.9)、(13391.4? 1823.8 )g respectively. The relationships between BMC and age and between LTM and age were positively correlated. BMD and LTM of the boys were significantly higher than those of the girls. On the contrary, FTM, %BF, F t/l and F t/a of the girls were obviously greater than those of the boys. Conclusion: DXA method may be used to evaluate the nutritional and developing status in preschool childran.

Objective To study microvascular density(MVD),DNA ploidy and immunophenotype in prostatic intraepithelial neoplasia(PIN) as well as their relationship with its biological properties.Methods We studied paraffin-embedded specimens from 24 cases of benign prostatic hyperplasia(BPH),23 cases of low-grade prostatic intraepithelial neoplasia(LGPIN),and 26 cases of prostatic carcinoma(PC) with high-grade prostatic intraepithelial neoplasia(HGPIN).Image analysis was used to measure the DNA average ploidy and MVD,and after that the expressions of 34?El2,P63,P504s and CD34 were detected by immunohistochemistry SP.Results DNA ploidy and MVD in PIN were higher than those in BPH,but lower than in PC,and correlation was detected among different grades of PIN.MVD had a positive correlation with DNA aneuploidy in different grades of PIN(P

Descending nociceptive modulation from the supraspinal structures plays an important role in cancer-induced bone pain (CIBP). Rostral ventromedial medulla (RVM) is a critical component of descending nociceptive facilitation circuitry, but so far the mechanisms are poorly known. In this study, we investigated the role of RVM glial activation in the descending nociceptive facilitation circuitry in a CIBP rat model. CIBP rats showed significant activation of microglia and astrocytes, and also up-regulation of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) and pro-inflammatory mediators released by glial cells (IL-1β, IL-6, TNF-α and brain-derived neurotrophic factor) in the RVM. Stereotaxic microinjection of the glial inhibitors (minocycline and fluorocitrate) into CIBP rats' RVM could reverse the glial activation and significantly attenuate mechanical allodynia in a time-dependent manner. RVM microinjection of p38 MAPK inhibitor (SB203580) abolished the activation of microglia, reversed the associated up-regulation of pro-inflammatory mediators and significantly attenuated mechanical allodynia. Taken together, these results suggest that RVM glial activation is involved in the pathogenesis of CIBP. RVM microglial p38 MAPK signaling pathway is activated and leads to the release of downstream pro-inflammatory mediators, which contribute to the descending facilitation of CIBP.

Objective To explore the ultrasonography findings and pathological features of adrenal ganglioneuroma and to improve diagnostic level. Methods Ultrasonography appearance and clinical pathological data of 12 cases of primary adrenal ganglioneuroma were retrospectively analyzed. The location, shape, size, echo characteristics, with or without calcification, the color signal of blood flow and its neighboring structure relationship on ultrasound were analyzed. Re-sults In 12 cases, 9 cases were found in the right adrenal gland and 3 cases in the left. All the tumors were solitary and the diameter was between 1.8 and 12 cm. The tumors were round or oval, some irregular or"embedded" growth. E-chogenic focus were found in 5 cases which was pathologically confirmed calcification, 3 cases of tumor showed a small dot color flow signal, all tumors with clear boundaries around the surrounding tissue. Pathology of tumor was mainly composed of ganglion cells and Schwann cells. Conclusion Ultrasonography is of great value in the diagnosis of adrenal ganglioneuroma owing to some specific sonograms.

Objective To study and discuss influencing factors of the elderly with ST elevation myocardial infarction (STEMI) underwent emergency percutaneous coronary intervention (PCI) after myocardial perfusion.Methods A total of 168 STEMI patients in our hospitalwere divided into total perfusion (CMP) group,reperfusion (PMP) group and non perfusion (NMP) group according to the integral contrast perfusion (APS) scores,including 54 cases in CMP group,96 cases in PMP group and 18 cases in NMP group.General information,coronary angiography and PCI results were compared,and the influencing factors of myocardial perfusion after primary PCI were compared by Logistic regression analysis.Results The general data showed significant difference in admission blood glucose,Killip grade,preinfarction angina incidence and balloon opening time,peak value of creatine kinase isoenzyme (CK-MB) and creatine kinase (CK) (P<0.05);In addition,there was significant difference in high thrombus load rate (P<0.05);Logistic regression analysis showed that the intravenous infusion of tirofiban,pre infarction angina,admission blood glucose,high thrombus load and onset to balloon time were factors affecting myocardial perfusion for PCI patients (P<0.05).Conclusion Blood glucose,intravenous infusion of tirofiban,preinfarction angina,high thrombus load and the onset to balloon time on admission are influencing factors for elderly STEMI patients after undergoing PCI myocardial perfusion.

Objective To study and discuss influencing factors of the elderly with ST elevation myocardial infarction (STEMI) underwent emergency percutaneous coronary intervention (PCI) after myocardial perfusion.Methods A total of 168 STEMI patients in our hospitalwere divided into total perfusion (CMP) group,reperfusion (PMP) group and non perfusion (NMP) group according to the integral contrast perfusion (APS) scores,including 54 cases in CMP group,96 cases in PMP group and 18 cases in NMP group.General information,coronary angiography and PCI results were compared,and the influencing factors of myocardial perfusion after primary PCI were compared by Logistic regression analysis.Results The general data showed significant difference in admission blood glucose,Killip grade,preinfarction angina incidence and balloon opening time,peak value of creatine kinase isoenzyme (CK-MB) and creatine kinase (CK) (P<0.05);In addition,there was significant difference in high thrombus load rate (P<0.05);Logistic regression analysis showed that the intravenous infusion of tirofiban,pre infarction angina,admission blood glucose,high thrombus load and onset to balloon time were factors affecting myocardial perfusion for PCI patients (P<0.05).Conclusion Blood glucose,intravenous infusion of tirofiban,preinfarction angina,high thrombus load and the onset to balloon time on admission are influencing factors for elderly STEMI patients after undergoing PCI myocardial perfusion.