1.Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
Priscilia LIANTO ; Yani ZHANG ; Huilian CHE
Asia Pacific Allergy 2019;9(3):e28-
Eosinophilic esophagitis (EoE) is a recently recognized esophageal inflammatory disease with clinical manifestations arising from esophageal dysfunction. The etiology of EoE is currently being clarified and food allergy is evolving as the central cornerstone of EoE disease pathogenesis. Given the large number of eosinophils in the esophagus of people with EoE verified by data from murine models EoE is widely considered as the hallmark T-helper type 2 (Th2) disease of the esophagus. It is also known that some eosinophilic inflammation is controlled by other subsets of T cells such as Th9 or Th17 and control is also exerted by type 2 innate lymphoid cells acting together with basophils. In this paper we review results from molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and present in-depth molecular understanding of EoE.
Animals
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Basophils
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Cytokines
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Eosinophilic Esophagitis
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Eosinophils
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Esophagus
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Food Hypersensitivity
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Humans
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Inflammation
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Lymphocytes
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Mice
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T-Lymphocytes
2.Evidence-based guidelines for food allergy of children in China
Wei ZHOU ; Jing ZHAO ; Huilian CHE ; Jianguo HONG ; Li HONG ; Hong LI ; Zailing LI ; Juan MENG ; Li SHA ; Jie SHAO ; Kunling SHEN ; Lianglu WANG ; Li XIANG ; Huan XING ; Sainan BIAN ; Nannan JIANG ; Hong JING ; Ling LIU ; Pengxiang ZHOU ; Weiwei ZHU
Chinese Journal of Applied Clinical Pediatrics 2022;37(8):572-583
The diagnosis of food allergy in children is one hotspot attracting people′s attention in recent years.The incidence of it shows an increasing trend which exposes problems in the understanding of children′s food allergy in China, especially in the misdiagnosis and missed diagnosis.To further standardize the diagnosis and treatment of food allergy in children, based on the current domestic, foreign guidelines and relevant research evidence, the guideline recommends 16 clinical hot-button issues in the 4 aspects of diagnosis, treatment, prognosis, and prevention.Finally, a diagnosis flowchart has been formulated.The guideline aims to improve the standard diagnosis and treatment of food allergies in children in China.