Objective:To investigate endoscopic treatment and its effects on non-varicose upper gastrointestinal bleeding in elderly patients.Methods:From June 2018 to September 2019, 86 elderly patients with non-varicose upper gastrointestinal bleeding treated in our hospital were enrolled and underwent endoscopic hemostasis.They were divided into the observation group(n=45, receiving endoscopic hemostasis combined with somatostatin treatment)and the control group(n=41, only receiving endoscopic hemostasis treatment). Clinical effects were evaluated in the two groups.Results:The immediate hemostasis rate was higher and the rebleeding rate within 1 week was lower in the observation group than in the control group(95.6% or 43/45 vs.80.5% or 33/41, 11.1% or 5/45 vs.29.3% or 12/41, χ2=4.740 and 4.460, P=0.030 and 0.035). Arrhythmias, multiple organ failure, and death during treatment occurred in 1 case, 0 cases, and 0 cases in the observation group and 4 cases, 2 cases, and 1 case in the control group, respectively.The incidence of complications was lower in the observation group than in the control group(2.2% or 1/45 vs.17.1% or 7/41, χ2=5.608, P=0.018). Conclusions:Endoscopic hemostasis combined with somatostatin treatment can not only achieve satisfactory hemostatic effects, but also reduce the incidence of rebleeding in elderly patients with non-varicose upper gastrointestinal hemorrhage, and thus plays an important role in alleviating suffering and ensuring safety in elderly patients.

Objective To establish the index system of nursing quality evaluation for patients with hematopoietic stem cell transplantation. Methods Based on the Donabedian structure-process-result three-dimensional quality management model, the evaluation index system of nursing quality of stem cell transplantation was constructed by combining qualitative and quantitative research of literature inquiry, case review, expert inquiry and analytic hierarchy process. Results Through the second round of expert consultation, the effective recovery rate of the expert questionnaire was 100% , the expert authority coefficient was 0.813, 0.859, and the coordination coefficient was 0.235 and 0.278 respectively (P< 01). Three primary indicators, 14 secondary indicators and 48 tertiary indicators were formed to evaluate the quality of care in stem cell transplantation. The index weight coefficient was established and the consistency test was passed. Conclusion The quality index system of hematopoietic stem cell transplantation nursing is well defined, its weight allocation is reasonable, the index is clear, and it is scientific and operational.

With the rapid development of antibody genetic engineering, bispecific antibody technology has been advanced. They are capable of binding two or more different epitopes simultaneously, thus offering specific advantages over natural monoclonal antibodies in immunotherapy. Bispecific antibodies have been successfully used in cancer therapy (e.g. melanoma, Hodgkin's lymphoma, liver cancer, and stomach cancer) and inflammation therapy (e.g. rheumatoid arthritis, psoriasis and Crohn's disease), but are still in their early stage for viral immunotherapy. In this study, we reviewed the research progress of bispecific antibodies for immunotherapy of virus infections, especially those with good effects in vivo and in vitro, to provide references for the research and development of bispecific antibodies for antivirus treatment.
Antibodies, Bispecific ; therapeutic use ; Antibodies, Monoclonal ; Epitopes ; Humans ; Immunotherapy ; Virus Diseases