1.Research progress on internal treatment of Chinese medicine in treatment of lung cancer
Chinese Journal of Biochemical Pharmaceutics 2015;(12):183-185
Drug laws were collected by summaring recent Chinese medicine treatment of lung cancer in etiology and pathogenesis , diagnosis and treatment, special disease post-party.It showed parts of the overall and the overall direction of lung cancer treatment.Especially in each lung cancer treatment of internal treatment experience.The traditional Chinese medicine in treatment of lung cancer lesions were stable , survival period longer and survival quality good advantage.For the treatment of modern western medicine, adverse effects, such as surgery, radiotherapy, chemotherapy and other adverse effects, the quality of life of patients can be improved by certain therapeutic method , which can provide protection for the treatment of the body. All aspects of the comprehensive treatment of lung cancer with Chinese medicine , pay attention to traditional Chinese medicine therapy for lung cancer attaches great importance to the protection of the patient’s quality of life, followed by the disease to improve treatment, overall see the prospect of traditional Chinese medicine in the treatment of lung cancer .
2.Quality of life questionnaires used in brain injury patients: a review
Huili CAO ; Kun HE ; Shuhao XUE
Chinese Journal of Practical Nursing 2017;33(26):2074-2076
A review of quality of life(QOL) questionnaires studies in brain injury patients, to help researchers choice reasonable measurement instruments, to provide a reference for the development of the local scale which more in line with China's national conditions and cultures. Universal scales:SIP-68, SF-36, SF-12, WHOQOL–BREF, PedsQL, et al. Specific scales:QOLIBRI, TBI-QOL, EBIQ. The sensitivity of universal scales is poor; Specific quality of life scales are more suitable for assessing the quality of living standards and changes in patients with brain injury.
3.High-resolution 3.0T magnetic resonance imaging in diagnosis of ligament and tendon injuries of the forefoot
Yaxiong LI ; Heng ZHANG ; Rongjie BAI ; Jine WANG ; Yupeng CAO ; Huili ZHAN ; Zhanhua QIAN
Chinese Journal of General Practitioners 2021;20(6):676-681
Objective:To evaluate the application high-resolution 3.0-T magnetic resonance imaging (MRI) in diagnosis of ligament and tendon injuries of the forefeet.Methods:From September 2014 to August 2020, 40 patients with forefeet injury (40 forefoot) and 20 healthy subjects (40 forefoot) meeting the including and excluding criteria were enrolled into this retrospective study. All subjects underwent MRI T1-weighted image (T1WI) and fat suppression proton density-weighted imaging (PD-FS) scan on coronal planes, sagittal planes and axial planes, respectively. Then the MRI characteristics of tendons in forefoot of healthy subjects and patients with forefoot injuries were compared. In patients the MR features of ligament and tendons injury were compared with the surgical findings or follow-up results.Results:In 20 normal subjects the tendons and ligament of the forefoot showed homogeneous low-signal-intensity on T1WI and PD-FS images. In the 40 patients with forefoot injuries, 22 cases were confirmed by surgical findings and 18 cases were confirmed by follow-up results. There were 8 cases of collateral ligament injuries, including 2 cases with complete tear, 3 cases with partial tear and 3 cases with sprain; 2 cases of extensor tendon with partial tear; 8 cases of flexor tendon injuries, including 3 cases with complete tear, 3 cases with partial tear and 2 cases with sprain; 3 cases of abductor tendon with partial tear; 13 cases of plantar plate injuries; and 6 cases of Lisfranc ligament injuries including 5 cases with complete tear and 1 case with partial tear. The injured ligament and tendons presented thicker and discontinuity in T1WI; and demonstrated heterogeneously increased signal intensity with edema in the surrounding soft tissues in PD-FS. The partially torn ligament and tendons showed discontinuity and thickening; and the completely torn ligament and tendons showed that they were interrupted and retracted, fiber structure disappeared and was filled with liquid, and edema in the surrounding soft tissue.Conclusion:High resolution magnetic resonance imaging of the forefoot can demonstrate the anatomy and features of ligament and tendon injuries in forefoot accurately, which has clinical application value for the early diagnosis and accurate treatment of the injury.
4.Comparison of High Volume Zero-Balanced Ultrafiltration With Different Replacement Fluid in Infant Patients
Fan CAO ; Guodong HUANG ; Huili YUAN ; Nan BAI ; Huaizhen WANG ; Xinxin CHEN
Chinese Circulation Journal 2014;(11):917-920
Objective:To compare the clinical effects of high volume zero-balanced ultraifltration (ZBUF) with different replacement lfuid in infant patients.
Methods: A total of 40 infant patients who received aortic coarctation with deep hypothermic circulatory arrest operation in our hospital from 2012-11 to 2014-02 were summarized. The patients were randomized into 2 groups, Group A, the patients had ZBUF with plasmalyte A, n=21 and Group B, the patients had ZBUF with modiifed replacement lfuid n=19. All patients received ZBUF (15-20) ml/kg during re-warming period until the temperature reached 34°C at rectum. Blood gas analysis were conducted at 4 time points as T1 (before CPB), T2 (open ascending aorta and 5 min after calcium perfusion), T3 (ifnishing ZBUF) and T4 (end of CPB). The intra-operative CPB time and the post-operative recovery with the complication were recorded in all patients.
Results: For blood gas analysis, the calcium concentration was higher in Group B than that in Group A at T3 time point, P<0.01 and the base excess was higher in Group A than that in Group B at T3 time point, P<0.05. Those indexes were similar at T1, T2 and T4, all P>0.05. The other indexes were similar between 2 groups, P>0.05 and the post-operative recovery was similar between 2 groups, P>0.05.
Conclusion: ZBUF with modiifed replacement lfuid could avoid decreased calcium concentration and acidosis, therefore, provide a relative stable homeostasis in infant patients.
5.Nursing care of patients with acute radiation-induced oral mucositis treated with Shenmai Decoction plus Gene Time
Chinese Journal of Modern Nursing 2014;20(30):3808-3811
Objective To explore the effect and nursing care of Shenmai Decoction plus Gene Time ( recombinant human epidermal growth factor ) on the treatment of radiation oral mucositis .Methods Totals of 80 head-and-neck cancer patients receiving radiotherapy were randomly divided into treatment group ( n=40 ) and control group (n=40).The treatment group was treated with Shenmai Decoction in combination with Gene Time spraying on the irradiated oral mucosa after cleaned , while the control group was treated only with Gene Time.The course of treatment of both groups was 7 weeks.The total curative effect of two groups were observed and the nursing methods were summarized .Results As the increasing dose of radiotherapy , the incidence rates ofⅢ-degree and Ⅳ-degree oral mucositis were increased significantly in the two groups (15.0% vs 25.0%, 25.0%vs 40.0%;χ2 =13.08, 10.31, respectively;P<0.05).However, the incidence rate of Ⅲ-degree andⅣ-degree oral mucositis of treatment group was significantly lower than that of control group ( 15 .0% vs 25.0%, 25.0%vs 40.0%;χ2 =9.21,14.39, respectively;P<0.05).And total effective rate of treatment group was significantly better than that of control group ( 87.5% vs 85.0%; χ2 =0.105, P >0.05 ). Conclusions Shenmai Decoction plus Gene Time can reduce the incidence of radioactive oral mucositis and significantly enhance the curative effect .Nursing interventions can improve the rehabilitation of oral mucositis patients.
6.Research progress and enlightenment of role model education for nursing students
Zhuoxi CAO ; Huili CAO ; Yifei DU ; Ya MAO ; Hui YANG
Chinese Journal of Modern Nursing 2024;30(15):2089-2095
Role model education has a profound impact on the attitude and behavioral development of nursing students. This article conducts a search and summary analysis of relevant literature in this field, elaborates on the concept and theoretical basis of role model education, sorts out the characteristics and roles of different types of role models and effective role models in the literature, summarizes the current application status of role model education in the nursing field at home and abroad, and proposes future research directions, aiming to provide reference for the future application of role model education in the nursing field.
7.Development of referral indications for low back pain with RAND-UCLA consensus panel method
Xiaona CAO ; Zhihong ZHENG ; Shuqi CUI ; Keqin RAO ; Yali ZHAO ; Juan LIU ; Bingqiang WANG ; Jing WU ; Juan DU ; Xiaoqin LU ; Dahong GAO ; Huili WANG ; Yadong WANG
Chinese Journal of General Practitioners 2010;09(12):824-828
Objective To study the validity of RAND-UCLA (Rand Corporation and University of California at Los Angeles) consensus panel method in developing guidelines of referral indications for low back pain (LBP).Methods Evidence-based clinical guidelines for LBP management at community level and its referral guidelines published since 2001 and other tools were retrieved with varied tools.All clinical guidelines met inclusion criteria were evaluated with clinical studies and evaluation tools (AGREE).An pool of indication items was established based on evidence for developing referral indications for LBP, which were added by RAND-UCLA consensus panel method, and alternative referral indications were selected and clinical guidelines for LBP referral were established.Results A total of 15 copies of clinical guidelines from nine countries or regions were included in it after critical appraisal.Four copies of referral guidelines from two countries were included.Referral indications for LBP were derived directly from the RAND-UCLA consensus panel process, consisting of 44 referral indications for three groups (immediate, urgent and routine referral).Conclusions The RAND-UCLA consensus panel method is a more useful and practical tool in developing clinical guidelines, referral guidelines, which is worthwhile being recommended and spread.
8.Relationship Between Coronary Artery Calcification and Pulse Pressure Difference in the Rural Population of Yunnan Province
Yi WANG ; Xinhua WU ; Ying YANG ; Zhangrong CHEN ; Tianzhao OUYANG ; Shiquan KUANG ; Yu DONG ; Lihua LI ; Bin LV ; Huili CAO ; Robert DETRANO
Chinese Circulation Journal 2014;(6):428-431
Objective: Based on coronary artery calciifcation (CAC) distribution in the rural population of Yunnan province, we further explored the relationship between coronary artery calciifcation score (CACS) and the pulse pressure difference (PPD).
Methods: A randomly stratiifed cluster sampling method was used to study the rural population of Yunnan province and 16-MDCT scan was performed in 212 subjects for evaluating their CAC and calculating CACS. The subjects were divided into 2 sets of groups according to the age and CACS value. Age (51-60) years group,n=108 and Age (61-71) years group,n=104; CACS<1 group,n=162, 1≤CACS<100 group,n=33 and CACS≥100 group,n=17. The PPD level and the relationship between CACS and PPD were compared among different groups.
Results: The average PPD level in Age (61-71) years group was (44.67±13.87) mmHg and in Age (61-71) years group was (50.00±17.44) mmHg,P=0.015, PPD was positively related to age, rs=0.202,P=0.003. The average PPD level in CACS≥100 group, CACS<1 group and 1≤CACS<100 group were (55.22±18.79) mmHg, (46.87±15.46) mmHg and (45.20±15.89) mmHg respectively,P<0.05. The patients with increased PPD level in CACS≥100 group was 47.1%, in CACS<1 group was 17.3% and in 1≤CACS<100 group was 15.2%,P<0.05. Spearman rank correlation analysis indicated that PPD level was positively related to CACS, rs=0.282,P=0.047, with adjusted confounding factors such as age and blood cholesterol level, the PPD was still positively related to CACS.
Conclusion: PPD as a risk factor of coronary artery disease is related to CACS in rural population of Yunnan province, the CACS increased accordingly with the elevated PPD level.
9.Research progress on the pathogenesis of immune checkpoint inhibitor-associated myocarditis
Zeyu WEN ; Huili CAO ; Yajing ZHAO ; Chengmei YANG ; Songshan LI ; Huwei DAI ; Kang ZENG ; Bin YANG
Chinese Journal of Geriatrics 2023;42(12):1489-1494
Immune checkpoint inhibitors(ICIs)have become the most widely used drugs in tumor immunotherapy, with ipilimumab and nivolumab as their representatives.However, the use of immune checkpoint inhibitors has brought about many immune-related adverse events, of which myocarditis is one of the most fatal adverse reactions.The pathogenesis of immune checkpoint inhibitor-associated myocarditis is not fully understood, mainly involving autoimmune T lymphocyte infiltration, regulatory T-cell dysfunction, cytokines, autoantibody production, genetic factors, the gut microbiome, etc.The treatment and management of immune checkpoint inhibitor-associated myocarditis require concerted efforts of multidisciplinary experts.
10.Intra- and interobserver reproducibility in the assessment of coronary artery disease: evaluation with invasive coronary angiography and CT coronary angiography
Mingli SUN ; Bin Lü ; Runze WU ; Shiguo LI ; Zhicheng JING ; Lei HAN ; Yanmin HUO ; Fangfang YU ; Shiliang JIANG ; Ruping DAI ; Jianhua LU ; Zhihui HOU ; Yang GAO ; Huili CAO ; Yongjian WU ; Yuejin YANG ; Shubin QIAO
Chinese Journal of Radiology 2012;46(2):104-109
Objective To investigate the intra- and interobserver repeatability of coronary artery disease (CAD) diagnosis based on invasive coronary angiography (ICA) and CT coronary angiography (CTCA).Methods Two readers with comparable experience ( over 10 years) independently evaluated ICA results of 42 consecutive patients with a blind method. After 30 days,one of them reviewed the same patients again.Another two comparable-experience (over 10 years) readers evaluated the results of CTCA (prospectively ECG-triggering) from the same 42 patients in the same way.The inter-reader and intra-reader repeatability of ICA and CTCA were analyzed by performing Kappa test and calculating the percentage of the segments with agreement on stenotic degree.Using ICA as reference,the accuracy of CTCA in diagnosing CAD was studied by comparing the area under ROC. Results The Kappa between readers for ICA and CTCA were 0.91 and 0.81.Intra-reader Kappa were 0.92 and 0.83 respectively (x2 =509.4 and 432.5,all P <0.01 ).The percentage of the segments with agreement between readers on the degree of stenosis were 80.8% (494/611) in ICA and 75.2% (469/624) in CTCA ( x2 =2.75,P =0.10),and within the same reader,86.9% (531/611)in ICA and 81.9% (511/624) in CTCA(x2 =3.76,P =0.053).With≥ 50%narrowing as a CAD diagnosis criterion,the agreement rates for two readers were 96.6% (590/611 ) in ICA and 94.4% (589/624) in CTCA( x2 =3.36,P =0.07),and for the same reader,97.4% (595/611) in ICA,95.4% (595/624) in CTCA ( x2 =3.62,P =0.06).Using ICA as reference,two readers of CTCA results achieved a sensitivity and specificity of 84.9% (530/624)and 98.1% (612/624).The area under ROC was 0.94 (95% CI 0.91-0.97).Conclusions Both ICA and CTCA demonstrate good repeatability in diagnosing CAD.The repeatability of ICA is superior to that of CTCA.A certain discrepancy exists in two readings from the same reader or two readers.