Objective To study the diagnostic value of homocysteine (Hcy) in coronary heart disease(CHD) .Methods 102 CHD patients were collected as CHD group [15 cases of acute myocardial infarction (AMI) ,56 cases of unstable angina pectoris (UAP) and 31 cases of table angina pectoris (SAP)] and 100 healthy subjects were collected as control group .The level of Hcy was measured by enzymatic cycling assay and the levels of folic acid (FA) and vitamin B12 (VB12 ) were measured by microparticle chemoluminescence immunoassay .Results The Hcy levels of patients with AMI ,UAP and SAP were significantly higher than con-trol group (P<0 .01) .The levels of AMI group ,UAP group and SAP group were (24 .12 ± 5 .87)μmol/L ,(22 .56 ± 6 .13)μmol/L and (17 .42 ± 5 .23)μmol/L ,respectively .Not only in CHD group ,but also in control group ,the level of Hcy in men was signifi-cantly higher than that in women .Similarly ,the level of Hcy were significantly higher in current smokers compared with non-smok-ers as well as in older group compared with young group .There were significant negative correlations between Hcy and FA (r= -0 .62 ,P<0 .01) and VB12 (r= -0 .47 ,P<0 .01) .Conclusion Hyperhomocysteinemia is significantly associated with CHD .Hcy may be an marker for early warning CHD .

Objective To discuss the correlation of high homocysteine (Hcy) hypertension (Htype hypertension) with serum levels of uric acid (UA) and fibrinogen (FIB) in the elderly.Methods A total of 188 elderly in-and out-patients with essential hypertension were selected in our heart medicine outpatient and ward from April 2013 to April 2014.They were divided into H type hypertension group (n =136,Hey value≥ 10μmol/L) and primary hypertension group (n =52,Hcy value＜10μmol/L).Another 160 elderly individuals without hypertension taking physical examination in our hospital during same period served as controls.General information were colleted,and the serum Hcy,UA and FIB were detected in all the patients to compare the differences among different groups.Logistic regression analysis was adopted to seek affecting factors of H-type hypertension patients.Results Compared with control group,there were statistical increases in the levels of UA and FIB for primary hypertension group and H-type hypertension group(P＜0.01).Compared with primary hypertension group,there were statistical differences in the level of UA and FIB(P＜0.01).The influence factors analysis showed that H-type hypertension was positively correlated with the serum level of UA and FIB(P＜0.01).Conclusions H-type hypertension is closely associated with UA and FIB.It's good for management of hypertension patients to monitor UA and FIB levels.

BACKGROUND: Serum levels of high-sensitivity C-reactive protein (hs-CRP) can be used to predict cardiovascular injury.OBJECTIVE: To investigate the serum levels of hs-CRP in a rabbit model of atherosclerosis following repeated long-termexposure to positive acceleration and to predict the risk of cardiovascular injury.METHODS: Twenty-four New Zealand purebred rabbits were randomly divided into a positive acceleration group and a controlgroup. Rabbits in the positive acceleration group were exposed to +4 g rotation for 20 seconds with an acceleration of 1 g/s. Therotation interval was 5 minutes and totally three rotations were daily performed for 3 days per week. 0.5 g rotation was addedevery week, and by week 4, +6 g rotation was added, and the exposure lasted for 40 seconds.RESULTS AND CONCLUSION: Exposure to positive acceleration yielded significant effects on serum level of hs-CRP in rabbitswith atherosclerosis compared with before exposure (P < 0.01), but exposure time did not produce effects on serum level ofhs-CRP (P > 0.05). The interaction between exposure to positive acceleration and exposure time also did not produce significanteffects on serum level of hs-CRP (P > 0.05). Hyperplastic foam cells in the aortic tunica intima and the superficial layer of mediaincreased with the prolongation of exposure to positive acceleration. Repeated long-term exposure to positive acceleration maylead to a long-term high serum level of hs-CRP in rabbits.

Objective Through the statistical analysis on literature on asthenia cold syndrome in recent ten years,to comprehend the present situation of studies on the feature and objectivization of symptom distribution of asthenia cold syndrome.Methods Collect literature on asthenia cold syndrome from the periodicals of traditional Chinese medicine and integrated traditional and western medicine from the year 1996 to 2006.The described features and objective indices of symptom distribution of this syndrome were systematically analyzed and summarized.Results In the literature,the diagnostic criteria of asthenia cold syndrome were made mainly by the authors themselves,few referring to others',being different in the descriptions of symptom distribution.The researches on objectivization indices were scattered,most of which took the single or multiple index(es) as subject(s).Conclusion Cold limbs,tiredness,aversion to cold,and loose stools are possibly significant in the diagnosis of asthenia cold syndrome.The way of the studies on diagnostic criteria and its objectivization of asthenia cold syndrome need to be improved.

Objectives To investigate the effect of different physical activities on the blood pressure in elderly patients with hypertension,and to provide evidence for the prevention and treatment of hypertension.Methods 256 elderly patients with grade 1,2 hypertension and no other complications,and 256 healthy elderly people were selected as the control subjects.According to the blood pressure and the level of physical activity,the patients were divided into hypertension combined with low physical activity group(HL group),hypertension combined with middle physical activity group(HM group),normal blood pressure combined with low physical activity group(NL group)and normal blood pressure combined with middle physical activity group (NM group).The changes of blood pressure were compared in quiet,during and after physical activity.Results The diastolic blood pressure(DBP) and systolic blood pressure(SBP) measured at rest,peak exercise and 5 minutes after exercise were significantly higher in group HL and HM group than in NL group and NM group,and the differences between groups were statistically significant(SBP:F=11.846、18.337、10.976,all P＜ 0.001 for all;DBP:F=13.182、11.694、11.453,all P＜0.05).The DBP and SBP in HL group at rest and 5 minutes after exercise were significantly higher than those in the HM group,and the difference was statistically significant(P＜0.05).The change magnitudes of DBP and SBP were significantly lower in HL group than in the HM group,and the differences were statistically significant (P ＜ 0.05).Conclusions Taking part in an appropriate exercise can improve blood pressure level and a recovery capability of post-exercise blood pressure in elderly patients with hypertension.

To explore the teaching model and effect of emergency care simulator(ECS) teaching in "Shock"during clinical bed side teaching,fifty-six students were randomly divided into two groups, receiving model and traditional teaching model respectively. After one semester,the students’examination results and general effect were evaluated. The students’ex-amination results,clinical theory and clinical skills in ECS teaching group were significantly better than traditional teaching group.

Objective To establish a sensitive ,reliable and convenient method for determination of total selenium(Se) in salt by HG-AFS. Methods The salt samples were dissolved and added hydrochloric acid (HCl),after heating by boiling water ,used HG-AFS to determinate Se. Results The linear range of the method was 0.5-400 ?g/L, The correlation coefficient was larger than 0.999 5, the recovery rates were 95.7%-102.8%. If 1 ml sample was collected, the detection limit was 0.08 ?g/L. Conclusion The method is sensitive, reliable, simple, less sample usage, and is an ideal method for determination of total selenium in salt.

Objective:To study the psychological he alth of the laid-off workers and its affecting factors in Changsha City. Methods:675 laid-off w orkers and 669 employed workers were interviewed with the Trait Coping Questionn aire (TCQ),the Social Support Rating Scale (SSRS),and the Life Event Scale(LES) .Demogra phic ,psychological and psychosocial factors that may affect psychological healt h of the subjects were analyed by stepwise regression method.Results: Psychological health condition was significantly affected by age ,marital status, educational level, economic status and duratio n of laid-off.Multiple stepwis e re gression analysis revealed that the major factors affecting psychological health were coping styles,recent life events ,perceived health impairment,educational level, economic pressure, and individual income.

Objective: To investigate the suicide ideation and related risk factors in laid-off workers in Changsha Method: By cluster sampling, 675 laid-off workers of 6 factories were collected 675 workers still at work matched by sex and age were collected as control All subjects completed Suicide Ideation Questionnaire, SCL-90, SES (self-esteem scale), TCQ (trait coping questionnaire), SSRS (social support rating scale) and LES (life event scale) Among all them, the data of 6 subjects was incomplete, therefore totally there were data of 1344 subjects (rate of drop-off was 0 4%) One-way and multiple logistic regression were employed to identify risk factors for suicide ideation Results: About one in four laid-off workers (23 4%) reported suicide ideation, 4 6% had a suicide plan or thought of exact methods, 2 8% had attempted suicide after unemployment Multiple unconditioned logistic regression analysis showed that the major risk factors for suicide ideation were suicide ideation before unemployment, poor mental health, negative coping style, recent life events, low income, poor social support and poor education Conclusion: The prevalence of suicide ideation among laid-off workers is much higher than that of general population Improving their mental health may be a helpful way to prevent suicide