Objective To investigate the influence of LNG-IUS placement on endometrial thickness, recurrence rate and complications of patients with endometrial polyps and moderate anemia after TCRP. Methods 140 patients with endometrial polyps and moderate anemia were chosen from January 2014 to January 2016 and randomly divided into control group (70 patients) with TCRP used alone and observation group (70 patients) with LNG-IUS placement after TCRP; the endometrial thickness, hemoglobin levels and PBAC score before and after treatment, the recurrence rate and the complication incidence of both groups were compared. Results The endometrial thickness after treatment of observation group were significantly less than control group before the treatment (P < 0.05). The hemoglobin levels and PBAC score after treatment of observation group were significantly better than control group before the treatment (P < 0.05). The recurrence rate of observation group were significantly lower than control group (P < 0.05). There was no significant difference in the complication incidence between the two groups (P > 0.05). Conclusion LNG-IUS placement in treatment of patients with endometrial polyps and moderate anemia after TCRP can efficiently reduce the endometrial thickness, decrease the uterine bleeding amount, prevent the long-term recurrence and not increase the complications incidence.

Asymmetric dimethylarginine(ADMA) is an endogenous inhibitor of nitric oxide synthases(NOS),which is a risk marker of cardiovascular endothelial dysfunction.Recent studies found that ADMA was a predictor not only for acute cardiovascular disease,but also for critical illness and mortality.Studies have found that exogenous ADMA altered lung function and induced apoptosis in animal experiments and vitro experiments.The levels of plasma ADMA significantly increased in children with hypoxia,PPHN,brain damage,and preterm infants who required mechanical ventilation.ADMA could be a independent risk factor to predict neonatal complications and death.

Activated protein kinase ( AMPK) , an important energy receptor , plays a very important role in regulating organ-ism and the energy metabolism of the cell .AMPK has complex relationship with survival of different types of breast cancer cells .Ac-cording to different conditions , AMPK may exist both anti or promoting effect on tumor .In this review , we summarize the relationship between AMPK and breast cancer related signal pathways , AMP and breast cancer endocrine therapy , breast cancer chemotherapy , ra-diotherapy for breast cancer , treatment of triple negative breast cancer and multi drug resistance of the relationship , we also expound some drugs related to AMPK and used in clinical setting .

0.05). Conclusion Tei index may be useful, convenient and reliable in fetal cardiac function assessment.

Objective To explore the effect of new labor standards on the intrapartum interventions and delivery outcome for gestational diabetes mellitus primiparas in labor by comparing with materal who were in accordance with the Friedman standards. Methods From May to November 2015, 319 singleton and full-term gestational diabetes mellitus primiparas whose labor treatment was according to new labor standards were selected as observation group. From November 2014 to April 2015, materal in accordance with the Friedman standards were selected as control group, a total of 292 cases, and then progress of labor, the usage of oxytocin, delivery way, postpartum hemorrhage, neonatal hypoglycemia and asphyxia were all observed. Results There was no significant difference between two groups in the rate of postpartum hemorrhage, neonatal hypoglycemia, neonatal asphyxia and neonatal mobidities (P>0.05). The total labor stage, the first labor stage and the second labor stage was (10.73 ± 4.00), (9.97 ± 3.89), (0.60 ± 0.38) h in observation group and (8.86 ± 3.09), (8.19 ± 3.00), (0.53 ± 0.31) h in control group, there was significant difference between two groups (t=18.184, 17.799, 6.798, all P<0.01). The incidence of artificial rupture, the usage of oxytocin, caesarean section was 22.57%(72/319), 16.93%(54/319), 5.64%(198/319) in observation group, and 28.77%(84/292), 22.95%(67/292), 9.59%(28/292) in control group, and there was significant difference between two groups(χ2=3.079, 3.476, 3.410, all P<0.05). The incidence of episiotomy was only 29.47% (94/319) in observation group, significantly less than that in control group, which was 51.37% (150/292), there was significant difference (χ2=30.490, P<0.01). Conclusions For gestational diabetes mellitus primipara, the new labor standards effectively reduce intrapartum interventions, the rate of cesarean sections and episiotomy, and more, less influence on maternal and newborn, which is helpful to promote the maternal reproductive health and natural delivery.

Objective To explore the influence of plasma homocystine(Hcy) level on the prognosis of acute cerebral infarction(ACI) and the effect of interventional therapy.Methods The plasma Hcy levels of 152 patients with ACI were measured by fluorometric method at

Objective To investigate the distribution features of upper limb involved nerves in patients with diabetic peripheral neuropathy (DPN).Methods The sensory nerve conduction velocity (SCV)and amplitude(SNAP),motor nerve conduction velocity(MCV)and amplitude(CAMP)of median,ulnar and radial nerves were examined in 98 DPN patients (DPN group) and 32 normal controls(NC group).The distributive ferture of involved upper limb nerves in DNP patients were analysed.Results (1) Comparing to NC group,the SCV and MCV of median,ulnar and radial nerves in DPN group were significantly slower (P

Pulse-taking is the most specific diagnostic method of TCM.Its significance has been recognized by ancient and modern doctors.However,at present the application and spread of pulse-taking is limited.In this paper,the author made detailed explorations of literatures and studies the value of pulse condition in guiding syndrome differentiation of liver diseases.The study shows abnormal pulse in left guan and taut pulse in cunkou location both suggest the liver is disordered.We can judge the location of diseases through pulse condition.This exploration shows pulse-taking plays important role in syndrome differentiation.But there is one thing should be paid more attention,pulse condition should be integrated with other symptoms,that will be reliable in guiding diagnosis.

Objective To investigate the differential expression of microRNAs(miRNAs) in transplanted kidney undergoing chronic rejection by the technique of RNA microarray.Methods Four biopsy specimens from transplanted kidney undergoing chronic rejection were harvested as test group(CR),and 3 biopsy specimens were obtained from normal renal cortex as normal control group(NC).Total RNA of each sample was extracted using Trizol reagent.miRNAs were isolated and differential expression of miRNAs were screened by miRNA array analysis.The results of miRNA array were validated by RT-PCR.The quantity and quality of all the RNA samples were checked by gel electrophoresis and absorbance at A260/280,respectively.Results It was confirmed that the isolated RNA was of appropriate quality.The results of miRNA array analysis showed that there were 63 differential expression miRNAs in CR group,of which 35 were up-regulated and 28 down-regulated.There were 9 differential expression miRNAs which distributed in 3 gene clusters: 14q32.31,22q11.21 and xq27.3.The miRNAs hsa-miR-637,hsa-miR-648 and hsa-miR-516-5p were randomly selected for relative quantification by real-time PCR.It was showed that the expression ratios of hsa-miR-637,hsa-miR-648 and hsa-miR-516-5p in AR/NC,when detected by RT-PCR,were 0.034,2.670 and 7.846,while the ratios were 0.035,2.660 and 7.857 when analyzed by miRNAs array.The results from two methods were not significantly different,so the method of miRNAs array was reliable.Conclusions It is notable that the differential expression of miRNAs existed in the transplanted kidney undergoing chronic rejection.miRNAs might be helpful in protecting the patients undergoing kidney transplantation against chronic rejection.

Objective To observe the effect of plasma exchange (PE)therapy for removing serum interleukin-6 (IL-6),tumor necrosis factor alpha (TNFα),and interferon gamma (IFNγ)in patients with liver failure,and to assess the value of artificial liver support system in the treatment of liver failure.Methods The study included 36 patients with liver failure who were hospitalized in the First Affiliated Hospi-tal of Bengbu Medical College from February 2012 to February 2013.Blood samples were collected before PE and the next morning after mul-tiple treatments.Plasma TNFα,IL-6,and IFNγlevels were measured by ELISA.Between-group comparison of measurement data before and after treatment was made by independent-samples t test,and comparison of mean values between groups was made by analysis of vari-ance.Results All the 36 liver failure patients had significantly lower levels of TNFα(381.23 ±190.57 ng/L vs 274.12 ±212.30 ng/L,P<0.05),IL-6 (77.9 ±83.09 ng/L vs 54.8 ±63.32 ng/L,P<0.05),and IFNγ(534.65 ±471.19 ng/L vs 259.65 ±312.26 ng/L,P<0.05)after treatment than before treatment.According to the severity of clinical manifestations,the patients with subacute or acute-on-chronic (subacute)liver failure were divided into early stage,middle stage,and advanced stage groups.There were significant differ-ences in IL-6 and TNFαdecreases between the early stage,middle stage,and advanced stage groups (P<0.05).IFNγdecrease signifi-cantly differed between the early stage or middle stage group and advanced stage group (P<0.05),but not between the former two groups (P>0.05).After PE therapy,29 out of 36 liver failure patients recovered well,while the remaining 7 patients deteriorated.The recovered group had significantly greater decreases in TNFα(122.58 ±57.64 ng/L vs 42.45 ±19.86 ng/L,P<0.05),IL-6 (26.93 ±7.25 ng/L vs 6.71 ±3.55 ng/L,P<0.05),and IFNγ(284.06 ±94.31 ng/L vs 217.47 ±45.76 ng/L,P<0.05)than the deteriorated group.The response rates of patients with acute,subacute,acute -on -chronic,and chronic liver failure were 66.67%,85.71%,86.36%,and 50%,respectively.Conclusion Continuous artificial liver PE therapy can effectively remove pro-inflammatory cytokines from plasma and thus improve the clinical outcomes of patients with liver failure.