Elderly acute myeloid leukemia (AML) accounted for 35 % of all AML with the increased incidence year by year, and the median onset age is 67 years old. Generally, AML patients require strong chemotherapy, but older patients often cannot tolerate intense chemotherapy due to the viscera dysfunction. It is still lack of unified treatment clinically. Reports on treatment of elderly AML in the 57th American Society of Hematology (ASH) annual meeting covered multiple fields, in which the traditional induction chemotherapy, demethylation drug alone or in combination with other drugs, and novel drugs were an involved. This article reviewed the latest research on the elderly AML in the 57th ASH annual meeting.

Objective:To investigate the relationship between antibiotics use and antimicrobial resistance of Acinetobacter bauman-nii to provide reference for rational antibiotics use. Methods:The DDDs of antibiotics in the inpatients and the drug resistance rate of A. baumannii were analyzed in our hospital from 2010 to 2014. The relationship between the antibiotics use and the antimicrobial re-sistance of A. baumannii was analyzed by SPSS 19. 0. Results:From 2010 to 2014, the total DDDs of antimicrobials in our hospital were decreased year by year in the first three years, while increased significantly in the last two years. The total DDDs of cephalospo-rins always ranked the first and the DDDs of carbapenem were increased year by year. The resistance rate of Acinetobacter baumannii a-gainst multiple antibacterials was increased in varying degrees in the past five years. In addition to levofloxacin, cefoperazone/sulbac-tam and tigecycline, the resistance rate against the other antibacterials was increased up to 50% in 2014. The resistant rate of A. bau-mannii against ciprofloxacin, gentamycin, cefepime, imipenem and tazobactam/piperacillin presented a positive correlation with the DDDs of cephalosporins and quinolones(P<0. 05). The resistance rate of A. baumannii against cefepime, imipenem tazobactam/pip-eracillin and levofloxacin was also positively correlated with the DDDs of carbapenem(P<0. 05). Conclusion: Antibiotics consump-tion is related to drug resistance of A. baumannii,so it is necessary to strengthen the management of clinical antibiotics use to decrease the multidrug-resistant strains.

This paper is devoted to discussing two research patterns of biological basis of traditional Chinese medicine syndrome and presenting a research strategy for data mining methods. It points out that data mining methods which are based on feature selection are better fit for investigating biological basis of traditional Chinese medicine syndrome. Based on such a discussion, the concept of "characteristic pattern" is proposed to bridge the gap between "golden index" and biological basis of traditional Chinese medicine syndrome. This paper presents a novel research avenue for investigating biological basis of traditional Chinese medicine syndrome.

Objective Chromatography fingerprint of Radix Codonopsis of different age from Shanxi province was studied to provide the reference for the science appraisal of intrinsic quality of Radix codonopsis. Method A RP-HPLC method was applied on GraceSmart-RP18 (250 mm?4.6 mm, 5 ?m) column with acetonitrile-0.1% acetic acid gradient elution as mobile phase, and the flow-rate was 0.6 mL/min. The detection wavelength was at 268 nm and the column temperature was at 30 ℃. Result Chromatography fingerprint of Radix Codonopsis can demonstrate obviously the difference and the similarity of Radix Codonopsis of different age. The RSD were lower than 3% in the precision, stability and the repetitiveness trial, and the codonopsis pilosula alkyne glucoside can be used as the reference to identify the active composition of Radix Codonopsis. Conclusion The method was simple, reproducible and reliable. The integrity of fingerprint can be used to supply the reference for the quality control of Radix Codonopsis from Shanxi provice.

Object To study IR absorption spectra of the extracts from chicken bile possessed excellent anti inflammatory and anticancer activity so as to develop this valuable resource.Methods Bile samples from chickens and various animals were dried in the dark and subjected to IR analysis respectively. Results By comparison, significant difference was found between IR spectra of chicken bile and other animals' bile, but the IR spectra of various chicken bile showed very good consistency. Conclusion The IR spectra of chicken bile is independent of raising places, species, feeding fashion, sampling season and age of sampled chicken. It was suggested that the bile of various chicken contained same chemical composition and this result was confirmed by UV and TLC analysis.

BACKGROUND: Cytridinie triphosphate(CTP) is predominantly used for cerebrovascualr accident and its sequelae, brain concussion, cerebral arteriosclerosis, senile dementia. What about its effect on diabetic peripheral neuropathies?OBJECTIVE: To observe the efficacy of cytridine triphosphate in improving nerve function and nerve conduction velocity in diabetic peripheral neuropathy.DESIGN: A prospective and randomized and controlled trial based on the patients.SETTING: Endocrine department of a military medical university.SUBJECTS: Totally 50 patients with diabetic peripheral neuropathy, hospitalized in Endocrine Department of Xijing Hospital of Fourth Military Medical University, were enrolled in this study from September 1999 to February 2000. All the patients were according to the including criteria, including 28 male and 22 female patients. They were randomly divided into treatment and control group averagely. Informed consent was obtained from all patients.METHODS: The 25 patients in treatment group received daily intravenous injection of 60 mg CTP. The other 25 in the control group received 100 mg vitamin B1 and 500 μg vitamin B12 and 20 mg scopolamine(654-2) and 100 mL saline as well every day. The treatment lasted for 14 days. The nerve conduction velocity was orthodromicly measured by surface electrode.MAIN OUTCOME MEASURES: Nerve conduction velocity in both groups.RESULTS: After treatment, the nerve conduction velocities of median nerve,ulnar nerve, fibular nerve, tibial nerve in the treatment group were higher than those in the control group (P < 0.05- 0. 01 ) . The neurological symptom and sign score in the treatment group(1. 4 ± 0.5, 3.0 ± 0.5) was less than that in the control group(2.6±0.3, 4.0±0.3) (t=3.255,2.005, P <0.05).CONCLUSION: CTP is effective in improving nerve conduction velocity in diabetic peripheral neuropathy.

Objective:To seek differentially expressed plasma proteins of unstable angina blood-stasis syndrome.Methods:2-dimensional di rence gel electrophoresis and mass spectrometry were used to screen the di erentially expressed plasma proteins among unstable angina blood-stasis syndrome and healthy volunteers.Results:Compared with healthy people,the express of Clusterin,ApoA-I of unstable angina blood-stasis syndrome patient decreased while the expression of Fibrinogen ? chain,Vitamin D-Binding Protein,Haptoglobin ? chain,Haptoglobin ?2 chain increased.Conclusion:Fibrinogen ? chain,Fibrinogen ? chain,Haptoglobin ? chain,Haptoglobin ?2 chain,Clusterin,ApoA-I may be correlative with blood-stasis syndrome.

BACKGROUND: Acute graft versus host disease (aGVHD) is still one of the barriers of allogenic hemopoietic stem cell transplantation in clinic. It has been proven that transforming growth factor-beta1 (TGF-?1), tumor necrosis factor-? (TNF-?) and interferon-? (IFN-?) abnormal secretion may be essential factors for aGVHD. OBJECTIVE: To explore the role of interleukin-4 (IL-4) and IFN-?, marker factors of Th1 and Th2, in aGVHD mice model of allogenic hemopoietic stem cell transplantation. DESIGN, TIME AND SETTING: Randomized controlled in vivo transplantation was performed at Department of Animal, Beijing Stomatology Hospital and Department of Hematology, Beijing Friendship Hospital, Capital Medical University from August to October 2005. MATERIALS: Twenty clean-grade male C57BL/6(H-2b) mice as donors were selected for harvesting bone marrow cells and spleen lymphocyte; fifty BALB/c(H-2d) female mice as recipients were randomly divided into control group (n=10), bone marrow cell transplantation group (n=20) and combination transplantation group (n=20). METHODS: Bone marrow cell group was injected with 2.0?107 marrow cells through tail vein, and combination transplantation group was injected with bone marrow cells and spleen lymphocyte of C57BL/6(H-2b) mice. Both groups were exposed to 6MV-X radiation (9.0 Gy). MAIN OUTCOME MEASURES: Mice survival time; peripheral blood leucocyte count; cytokine levels in peripheral serum by ELASA; histopathological alterations by HE staining. RESULTS: Mice in marrow cell group died since the eighth day, while those in combination group since the fourth day. Kaplan-Meier exhibited P 0.05). Compared with marrow cell group, the levels of IL-4 were significantly decreased (P

Objective To understand the influence of personal feature on nurses' professional identity.Methods Nurses of 6 military hospitals were assessed and analyzed by general data questionnaire,Nursing Professional Identity Scale.Results Nurses' professional identity in military hospital was on the moderate level.Nursing age,department,monthly income,position,gender entered into the regression equation of nurses' occupation,which affected positively nursing professional identity.Conclusions The military nursing managers should raise the income of nurses appropriately,especially pay attention to training of professional identity of seniority nurses and local recruitment nurses,and enhance master concept in order to increase their understanding and recognition of their occupation.

Objective · To observe the effects of custom made fiber posts on the fracture resistance of young permanent teeth treated with calcium hydroxide for different time. Methods · Forty-five extracted human young permanent teeth (premolar) were selected and randomly assigned to 9 groups.One group was the control group and the rest 8 groups were treated with conventional root canal preparation. Of these 8 groups, 4 groups (F Ⅰ , F Ⅲ , F Ⅵ ,FⅨ ) were restored by custom made fiber posts after being treated with calcium hydroxide for 1, 3, 6, and 9 months respectively, and other 4 groups (C Ⅰ ,CⅢ , C Ⅵ , C Ⅸ ) were not restored by custom made fiber posts. All samples underwent fracture strength tests and their fracture modes were analyzed for the possibility of second repair. Results · The fracture load was decreased with the treatment time after being treated with calcium hydroxide for 1 month (P<0.01). The fracture loads in groups restored by custom made fiber posts were increased after being treated with calcium hydroxide for 6 and 9 months (P<0.05, P<0.01). After being treated with calcium hydroxide for 1 month, groups restored by custom made fiber posts were likely to have fracture modes that facilitate the second repair as compared with groups not restored by custom made fiber posts (P<0.05). Conclusion · The restoration by custom made fiber posts can increase the fracture resistance of young permanent teeth treated with calcium hydroxide for medium and long term ( ≥ 1 month).