In order to understand the clinical research progress of epidermal growth factor receptor inhibitors,the author reviewed the related research and literature report.It considers that cetuximab is mainly used for colorectal cancer without KRAS gene mutations,and trastuzumab is mainly used for breast cancer and gastric cancer with over expression of HER-2,and gefitinib and icotinib is mainly used for non-small cell lung adenocarcinoma with EGFR gene mutations.The above points of view can provide reference for the clinical application of these drugs.