Objective:To investigate the protective effect of warning at different time points on eyewitness memory during repeated memory retrieval.Methods:A pilot test and artificial intelligence technology were used to develop a set of witness memory experiment procedures applicable to Chinese people. A total of 46 healthy participants were included in the pilot test and 101 healthy participants were included in the formal experiment. A mixed 3 (group of warning) ×4 (memory test time points) design was applied to this study and SPSS 23.0 software was used for data analysis.The memory of 101 healthy participants (33 in the pre-warning group, 30 in the no-warning group, and 38 in the post-warning group) using two-factor repeated measure ANOVA. The memory accuracy rate, memory misleading rate and confidence of the three groups in different memory test time points were taken as dependent variables, and the group of warning and the test time points were taken as independent variables to analyze the differences in memory among the groups in different test time points.Results:(1)In the early two repeated memory tests, the accuracy of memory in pre-warning group ((0.67±0.11), (0.67±0.12)) were significantly higher than those in no warning group ((0.58±0.15), (0.60±0.15)) (both P<0.05); at the third repeat memory test, the accuracy of post-warning group (0.63±0.12) and no warning group (0.60±0.13) were significantly lower than that of pre-warning group (0.69±0.12) (both P<0.05). (2)In the three repeated memory tests, the memory misleading rates of the pre-warning group (0.25(0.13, 0.38), 0.25(0.13, 0.38), 0.25(0.13, 0.38)) and the post-warning group (0.25(0.13, 0.38), 0.25(0.13, 0.38), 0.25(0.13, 0.38)) were significantly lower than those of the no warning group (0.63(0.34, 0.78), 0.63(0.34, 0.75), 0.63(0.25, 0.75)) (all P<0.05). (3)There were no significant difference in the answer confidence between any pair of groups at any corresponding memory test (both P>0.05). Conclusion:The protective effect of warning before misleading information is better than the warning after misleading information, and the protection of the two warnings are still working.

Objective:Based on the pathological model of acceptance and commitment therapy(ACT), to explore the correlation between cognitive fusion and resting-state spontaneous brain activity amplitude of low frequency fluctuation in patients with major depressive disorder(MDD).Methods:Patients with MDD ( n=19) and healthy controls (HCs, n=19)matched with gender, age, and years of education were enrolled from August 2022 to May 2023 in Hangzhou Seventh People's Hospital. 17-item Hamilton depression rating scale(HAMD-17) and cognitive fusion questionnaire(CFQ) were used to estimate the depressive symptoms and cognitive fusion of the participants. The amplitude of low frequency fluctuation(ALFF) data were collected on a 1.5 T-GE scanner. Based on DPABI v7.0 software of MATLAB 7.11.0 (R2018b), two independent sample t-test was used to compare the ALFF of the MDD group and HC group. ALFF values and the cognitive fusion scale scores were investigated by Pearson correlation analysis. Results:Compared with HCs, ALFF in patients with MDD was decreased relatively in the left triangular part of the inferior frontal gyrus(MNI: x, y, z=-36, 24, 21; t=-2.107, P=0.042), the right cuneus(CUN; MNI: x, y, z=12, -87, 24; t=-8.635, P<0.001) as well as the left calcarine fissure and surrounding cortex(MNI: x, y, z=-18, -57, 6; t=-14.188, P<0.001), while increased relatively in left superior occipital gyrus(MNI: x, y, z=-21, -72, 33; t=-7.253, P<0.001). There was a significant negative correlation between cognitive fusion and ALFF values of abnormal activity in left IFGtriang (belonging to ECN)( r=-0.57, P<0.05). Conclusion:There is a correlation between cognitive fusion and resting-state spontaneous brain activity ALFF in patients with MDD. Both cognitive fusion and depressive symptoms may affect patients' cognitive control deficits through multiple sources.