4.Effect of nicardipine on perioperative insulin sensitivity in patients with essential hypertension
Yujun MING ; Hui LI ; Junmei XU
The Journal of Clinical Anesthesiology 2010;26(2):97-99
Objective To investigate the effect of nicardipine on perioperative insulin sensitivity in patients with essential hypertension(EH). Methods Thirty-eight patients undergoing lobectomy continuously after induction of anesthesia in group N, while normal saline was infused in group C instead of nicardipine. Blood samples were taken immediately before induction of anesthesia(T_0), 2 h after skin incision(T_1) ,4 h after surgery(T_2) and 24 h after surgery(T_3). Blood glucose(BG) and plasma insulin (Ins) were measured. The Insulin sensitivity index (ISI) was calculated. Results Values of BG at T_2and T_3 in group C were higher than those at T_0 (P<0. 05). Value of Ins at T_2 in group C was higher than that at T_0 (P<0. 05),which at T_3 in group C was significantly higher than that at T_0 (P<0. 01). ISI at T_2 in group C was lower than that at T_0 (P<0. 05) ,which at T_3 in group C was lower significantly than that at T_0 (P<0. 01). Values of BG and Ins at T_3 in group N were higher than those at T_0 (P<0. 05), ISI at T_3 in group N was lower than that at T_0 (P<0. 05). Value of BG at T_2 was significantly lower in group N than that in group C(P<0. 05). Value of Ins at T_3 was significantly lower in group N than that in group C(P<0. 01). ISI at T_2 and T_3 in group N was min~(-1) infused continuously during and after lobectomy can increase significantly insulin sensitivity and improve postopertive insulin resistance state in EH patients.
5.Electrogastrographic parameters from 40 healthy subjects 6 to 14 years of age.
Yan YANG ; Hui-min YAN ; Ming LI
Chinese Journal of Pediatrics 2005;43(9):697-698
Adolescent
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Child
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Electromyography
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Female
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Humans
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Male
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Stomach
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physiology
6.Latest advancement in designing and evaluation of MDR inhibitors targeting P-glycoprotein
ming-hui, CHEN ; xun, LI ; kang-hui, YANG
Journal of International Oncology 2006;0(09):-
Over-expression of P-glycoprotein (Pgp) is associated with the development of multi-drug resistance ( MDR). Pgp has been focused on as the main target in designing chemotherapy strategy. In this article we review some of the latest advancement in designing and evaluation methods of P- glycoprotein inhibitors.
7.Relationship between neuronal ?4?2 nicotinic acetylcholine receptor and neurological diseases
hui-zhen, NIE ; wei, LI ; rui-li, NIE ; ming, YIN
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(06):-
Neuronal?_4?_2 nicotinic acetylcholine receptors(nAChRs) are the most widespread subtypes in central nervous system.?_4?_2 nAChRs mainly exist in procerebrum,parietal lobe cortex,temporal lobe cortex,hippocampus,basal ganglion and cerebellum.Researches on gene knock-out mice have demonstrated that?_4?_2 receptors participate in the development,aging,neuron survival,pain,and learning and memory,and are also involved in gamma-aminobutyric acid release and dopaminergic function.Studies have disclosed that?_4?_2 nAChRs relate to the development of variety of neurological diseases,including pain,Alzheimer's disease and Parkinson's disease.
8.Relationship between neuronal α4β2 nicotinic acetylcholine receptor and neurological diseases
Hui-zhen, NIE ; Wei, LI ; Rui-li, NIE ; Ming, YIN
Journal of Shanghai Jiaotong University(Medical Science) 2009;29(6):744-746
Neuronal α4β2 nicotinic acetylcholine receptors (nAChRs) are the most widespread subtypes in central nervous system, α4β2 nAChRs mainly exist in procerebrum, parietal lobe cortex, temporal lobe cortex, hippocampus, basal ganglion and cerebellum. Researches on gene knock-out mice have demonstrated that α4β2 receptors participate in the development, aging, neuron survival, pain, and learning and memory, and are also involved in gamma-aminobutyric acid release and dopaminergic function. Studies have disclosed that α4β2 nAChRs relate to the development of variety of neurological diseases, including pain, Alzheimer's disease and Parkinson's disease.
9.Influence of cationic cyclopeptide on microstructure and permeability of Caco-2 cell membrane.
Xiao-Hui LI ; Ming-Ming CHANG ; Qing WANG ; Yu-Ming SUN ; Yang LIU
Acta Pharmaceutica Sinica 2014;49(7):1062-1068
The microstructure of cationic cyclopeptide (TD-34) treated Caco-2 cell membrane was observed, and we discussed the relationship between membrane structure and insulin transmembrane permeability. Atomic force microscope (AFM) was used to observe living cell membrane in air condition and tapping mode. Results showed that the surface of Caco-2 cell membrane treated with TD-34 lost its smoothness and nearly doubled its roughness. Apparent permeability coefficients (P(app)) of insulin in Caco-2 cell monolayers increased 2.5 times. In conclusion, AFM can be used to observe microstructure of cationic cyclopeptide treated cell membrane and cationic cyclopeptide enhanced insulin delivery across Caco-2 cell membrane by increasing membrane fluidity.
Caco-2 Cells
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Cations
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Cell Membrane
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drug effects
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Cell Membrane Permeability
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drug effects
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Humans
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Insulin
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metabolism
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Membrane Fluidity
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drug effects
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Microscopy, Atomic Force
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Peptides, Cyclic
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pharmacology
10.Successful treatment in 46 cases of acute poisoning .
Su-hui SU ; Cheng-ming GEO ; Hong-ten LI
Chinese Journal of Industrial Hygiene and Occupational Diseases 2003;21(4):291-292
Acute Disease
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Adolescent
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Adult
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Benzene
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poisoning
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Cough
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etiology
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Dexamethasone
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therapeutic use
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Fatigue
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etiology
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Female
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Glucocorticoids
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therapeutic use
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Glutathione
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therapeutic use
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Humans
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Length of Stay
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Male
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Middle Aged
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Occupational Diseases
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etiology
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therapy
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Occupational Exposure
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adverse effects
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Treatment Outcome