Erectile dysfunction(ED) is a common condition in men from 40 to 70 years of age,and during the last decades intensive research has highlighted clinical practice and public sectors.The development of Sildenafil,Vardenafil and Tadalafil have made the first class of agents capable of treating ED with convenient oral administration available.In the past years intracavernosal and intraurethral agents have been developed,but their clinical use was limited due to its invasiveness,and with high discontinuation rates.Gene therapy will be an effective method in future.

OBJECTIVE:To discuss the significance of prescription analysis in Chinese drugs dispensing and to probe into the profound connotation of the dispensing of prescriptions of traditional Chinese medicines.METHODS:Take the basic theory of Chinese medicine as the basis,the importance of prescription analysis in the dispensing of traditional Chinese medicines were analyzed from aspects of the patients' clinical diagnosis,medication intention as well as the function and properties of drugs etc.RESULTS:8 essential factors were found to be involved in prescription analysis,which shed new light on the omnidirectional pharmacy care provided for patients.CONCLUSION:The key for Chinese drugs dispensing lies in the prescription analysis.

OBJECTIVE:To prepare hydrocortisone lotion and establish its quality control method. METHODS: The lotion was prepared with hydrocortisone, and the content of hydrocortisone was determined by ultravidet spectrophotometry. The stability of the prepartion and its skin stimulus were investigated as well. RESULTS: The preparation was colorless limpid liquid and up to the standard specified in Chinese Pharmacopeia (2005 Edition) in the related test. The linear range of hydrocortisone was 5.0～30 ?g?mL-1(r=0.999 0) and the average recovery was 100.09% (RSD=0.17%). After storing for 3 and 6 months, respectively, no obvious change was noted for the preparation. The skin stimulus experiment showed that it caused no side effects such as erythema on skin or edema etc. CONCLUSION: This lotion is simple in preparing process, and its quality is stable and controllable.

Objective To discuss the feasibility of application of laryngeal mask airway(LMA)in pediatric corrective surgery of lingual frenum. Methods Retrospective study was conducted of 42 chil-dren using laryngeal mask airway in selective surgical correction of lingual frenum under general anesthe-sia in our hospital. The childrenˊs vital signs were recorded at five different time points:baseline before an-esthesia(T0),consciousness and eyelid reflex disappear just after anesthesia induction(T1),time right af-ter the LMA insertion(T2),3 ~ 5 min after beginning of operation(T3),and time at the extubation(T4). The success rate of first LMA insertion and the number of changing to other ventilation way were recorded. The shift of LMA and postoperative sore throat within 24h were recorded. Results The success rate of the first LMA insertion was 85. 71% . Intraoperative laryngeal mask airway leak and shift did not occur and the ventilation was also good. Vital signs of the children were stable during operation. The incidence of postop-erative sore throat was 15% within 24h. As to the heart rate,the vital signs of baseline T0 were significant-ly different from other time points(T1,T2,T3,T4). After the anesthesia,there were no significant differ-ences in heart rate among different time points(T1,T2,T3,T4). Compare with T2 and T3,the values of partial end expiratory pressure of CO2 at T0,T1,and T4 were significantly different. Compare with T0,the values of mean arterial pressure at T1,T2 and T3 were significantly different,but there was a significant difference in mean arterial pressure between T1 and T4. As to the pulse oxygen saturation,all the values were above 95% . Conclusion Laryngeal mask airway is a supraglottic airway management method. The advantages of fewer haemodynamic changes and postoperative complication are confirmed. It is feasible and safe for securing the airway in surgical correction of lingual frenum.

Objective To evaluate relationship and singnificance between metabolic syndrome (MS) and carotid atherosclerosis. Methods One hundred subjects were investigated,including 54 MS patients and 46 normal subjects.Body mass index,waist circumference,plasma lipid and fast glucose of all subjects were examined.Carotid intima-media thickness (IMT) was detected and plaque was scored with color Doppler ultrasound. Results The MS patients had significant higher carotid IMT,diameter,plaque index and plaque occurrence rate than those in normal ones. Conclusions The degree of carotid atherosclerosis in MS is much more severe than that in normal patients.The metabolic syndrome may promote the occurrence and the progress of atherosclerosis.Carotid ultrasonograohy may help diagnose coronary artery disease much earlier.

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia,which is rare in children.The treatment of APL mainly includes anthracycline-based chemotherapy,all-trans retinoic acid,and arsenic trioxide,which allow for complete remission,improve the long time survival rate and reduce related toxicity as well.About the optimized treatment,quick breakthroughs have already reached,not only at home in the 80's at the end of the 90's,but also abroad,like National Comprehensive Cancer Network of the United States in 2006-2013.This review summarizes the progress in diagnosis and treatment of children with APL.

Objective To investigate the effects of different tidal volume (V_T) on arterial oxygenation and intrapulmonary shunt(Q_S/Q_T) during one lung ventilation(OLV).Methods Sixty patients scheduled for selective lobectomy under left lateral decubitus position were randomly divided into groups of A,B and C with 20 cases each.After bronchial induction,two lung ventilation(TLV) was performed with V_T 10 ml/kg,frequency(f) 12 breaths per minute(BPM),ratio of inspiration to expiration(I: E) was 1:2 at first.During OLV,I: E was kept steady,V_T 6 ml/kg and f 20 BPM were chosed in group A,V_T8 ml/kg and f 15 BPM in group B,V_T 10ml/kg,f 12 BPM in group C.Blood gas analysis was determined before OLV (T_1) and at 10 min(T_2) ,20 min(T_3) ,and 30 min after OLV (T_4).Q_S/Q_T and lung complience(Cdyn) was calculated.Results OLV Compaired to T_1,PaO_2 and Cdyn were lower (P<0.05) and Q_S,Q_T and peak airway pression were increased (P<0.05).The decrease of PaO_2 was more in groups of A and C than that in group B(P<0.05).Conclusion During OLV,a better PaO_2.may be maintained with the ventilation parameters of V_T8 ml/kg and f 15 BPM with less increase in Q_S/Q_T and higher Cdyn.

Objective To investigate the effects of different dose of edible liquor on cardiac structure and function in rats ,and explore its underlying mechanisms .Methods 54 male SD rats were randomly divided into saline group ,alcohol group ,liquor group , each group were further divided into low-,middle-and high-dose groups .After 12 weeks of feeding ,left ventricular pressure was de-termined ,and left ventricular pressure amplitude and indexes of HW /BW were calculated .Myocardial fibrosis was observed by Masson staining ,AngⅡ content of myocardial tissue were detected by ELISA ,and ACE and ACE2 mRNA expressions were detec-ted by RT-PCR ,respectively .Results Left ventricular pressure amplitude and HW/BW index were increased by both liquor and al-cohol .The myocardial cell turbidity ,degeneration ,hyperplasia of fibrous tissue change were gradually worsened ,and the AngⅡ con-tents and the ACEmRNA expressions of the myocardial tissue were also increased by both liquor and alcohol .The ACE2 mRNA ex-pression of the myocardial tissue were higher by low-dose liquor and alcohol ,while the ACE2 mRNA expression of the myocardial tissue were lower by middle-and high-dose liquor and alcohol .Conclusion Long-term alcohol consumption can damage the balance of cardiac ACE and ACE2 ,causing the increase of ACE ,AngⅡ and the decrease of ACE2 ,resulting in myocardial fibrosis ,whose degree is related to the amount of alcohol consumption and drinking history .

[Objective] This paper sums up Professor Liu Ruifen's scholar thought and clinical experience in diagnosing and treating menopause reheating sweating symptoms.[Methods] From the aspects of the pathological mechanism, clinical manifestation and treatment based on syndrome differentiation of menopause reheating sweating symptoms, this paper sums up Professor Liu Ruifen's scholar thought and clinical experience in diagnosing and treating the disease. At the same time, this paper also sums up Professor Liu Ruifen's experience in Chinese materia medica and presctiptions and rehabilitation. [Re-sults] The pathogenesis of this disease is kidney yin deficiency, Chong and Ren disorders; nourishing yin combined with inhibing Yang to remove heat is the big iethod.[Conclusions]Professor Liu Ruifen's scholar thought and clinical experience in diagnosing and treating menopause reheating sweating symp-toms is effective and is trusted and welcomed by patients. Her thought and clinical experience are worth to extend and apply.

Objective: To investigate the effects of grape seed proanthocyanidin(GSP) and casein peptide on the liver function and protein nutritional status in rays irradiated rats. Methods: Adult wistar rats were randomized into four groups with 20 rats in each group including normal control, radiation control, GSP and GSP+casein peptide combined groups. The GSP group was fed with basic diet containing 1% GSP, the combined group was fed with basic diet containing 1% GSP plus 5% casein peptide. Animals except normal control were irradiated by 60 Co? rays(7Gy) 10 days later. 6 survivors were randomly selected from each group and killed on the 7 th d after radiation. The levels of the total protein (TP) and the albumin (ALB), the activities of the glutamate pyruvate transaminase(GPT) and the glutamate oxaloacetale transaminase(GOT) in serum were measured. The change of the body weight of the animals was observed during the experiment time. Results: After radiation the body weight of the rats dropped sharply. The loss of the weight in combined group were significantly lower than in radiation control group and in GSP group(P