1.Comparative study of intravenous thrombolysis treatment of cardiogenic cerebral infarction and noncardiac cerbral infarction
Weihua DENG ; Yong YANG ; Xiaoping PAN ; Ze LI ; Jin ZHOU ; Hui HUANG ; Haobo CHEN
The Journal of Practical Medicine 2015;(11):1781-1783
Objective To compare the efficacy and safety of intravenous thrombolysis on cardiogenic cerebral infarction and noncardiac infarction by recombinant tissue plasminogen activator (rt-PA). Methods Comparations of NIHSS, mRS and adverse events before and after treatment were made between the cardiogenic group and the noncardiac group. Results No significant differences in the NIHSS and mRS were found between the two groups. The incidence of brain hernia and dermatorrhagia in the cardiogenic group was higher than that in the noncardiac group. Conclusion Rt-PA therapy in cardiogenic cerebral infarction was effective and safe in spite of higher incidence of hemorrhage and brain hernia.
2.Long-term follow-up and humanistic care for patients with hypophyseal tumor.
Han-ze DU ; Kang LI ; Hui-juan ZHU ; Hong-wei DU ; Hui PAN
Acta Academiae Medicinae Sinicae 2011;33(2):116-119
The number of new cases of hypophyseal tumor increases along with the advances in neuroimaging technology in recent years. The common treatment models include surgical treatment, radiotherapy, and medical therapies. This article discusses the application of long-term follow-up in non-operative hypophyseal tumor patients and its influence on the prognosis. Meanwhile, since the medical mode has switched from biomedical model to biopsychosocial medical model, management of hypophyseal tumor should not be limited in its biological aspect, but also from the perspective of psychology by providing more humanistic care to meet the patients'psychological needs.
Follow-Up Studies
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Humans
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Pituitary Neoplasms
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therapy
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Prognosis
3.Multiple soft tissue defects of hand repaired by muliplefoliated tissue flap only pedicled by descending branch of lateral circumflex femoral artery
Wen-ya ZHANG ; Hui-guo WU ; Yu-xiang HU ; Dong-ning SONG ; Ya-fei HU ; Ke-luo NG JIA ; Ze-ang PAN ; Yun-feng WANG ; Bin-hui LI
Chinese Journal of Microsurgery 2011;34(4):280-282
ObjectiveTo introduction of perforator flaps,muscle flaps pedicled by descending branch of lateral circumflex femoral artery,method and their clinical application that multiple soft tissue defects of hand are repaire by muliplefoliated tissue flap only branch lateral circumflex femoral artery.MethodsFifteen patients with multiple soft tissue defects of hand were repaired muliplefoliated tissue flap only pedicled bydescending branch lateral circumflex femoral artery.At first,the anterolateral thigh perforator flap was designed and harvested according to the soft tissue defects of hand, then the descending branch lateral circumflex femoral artery was dissected at the same time the segmented perforator flap,fascia lata flap,rectus femoris muscle flap, vastus lateralis muscle flap, vastus intermedius muscle flap and distal spatium intermusculare flap were harvested in need according to distance among soft tissue defects.The muliplefoliated tissue flap was harvested only pedicled by descending branch lateral circumflex femoral artery, at last muscle flaps and fascia lata flaps were covered by skin graft, so the multiple soft tissue defects of hand were repaired in one time.ResultsNo vascular crisis happened. All skin grafts survived well, the contour of all repaired soft tissue defects was good and protective feeling was recovered by skin grafts of all flaps. All cases were got follow-up and the range was from 6 to 20 months(the average was 8.7 months).Wound of donor site healed well, muscle strength of quadriceps and motion of knee were normal. Three cases were excellent,nine cases were well and 3 cases were good, according to upper extremity function evaluation criteria of Chinese Medical Society for the Surgery of the Hand, the rate of good was 80 percent.ConclusionMultiple soft tissue defects of hand can be repaired by muliplefoliated flap only pedicled by descending branch of lateral circumflex femoral artery. Its advantages included reduction of operation time and treatment, good recovery of hand contour and function. It is a good method to repair multiple soft tissue defects of hand.
4.Clinical analysis of 60 thyroglossal tract cyst cases.
Chun LIN ; Ze-geng GUO ; Le-zhong TENG ; Zu-hui PAN ; Bo CHEN ; Hong-ping LI ; Guo-bin LI
West China Journal of Stomatology 2007;25(3):263-265
OBJECTIVETo study the characteristics of thyroglossal tract cyst epidemiology and summarize how to improve the operation therapeutic effect.
METHODSThe clinic appearance, the pathological characteristics and the therapeutic effect of the 60 thyroglossal tract cyst cases were analyzed.
RESULTSThyroglossal tract cyst mostly occurred in children and teenagers. The incidence of female patients was more than that of male patients. Most of thyroglossal tract cyst located in the middle line of the neck and were explored tubular-objects and fibroropes. The histopathological feature was variform.
CONCLUSIONThe clinical appearance and pathology characteristic of thyroglossal tract cyst are variform. Thyroglossal tract cyst may be recurred easily if it is not operated well.
Adolescent ; Child ; Female ; Humans ; Male ; Thyroglossal Cyst
5.Clinical analysis of misdiagnosis in 70 children with primary hypothyroidism.
Du Han ZE ; Li KANG ; Pan HUI ; Du GONG-WEI
Acta Academiae Medicinae Sinicae 2011;33(1):14-17
OBJECTIVETo analyze the causes of misdiagnosis of primary hypothyroidism (PH), with an attempt to reduce the misdiagnosis or mistreatment.
METHODSTotally 70 PH children with a history of misdiagnosis but whose conditions were confirmed in Peking Union Medical College Hospital and the First Hospital of Jilin University from July 2000 to May 2009 were enrolled in this study. The clinical data were collected and the causes of misdiagnoses were analyzed.
RESULTSOf these 70 patients, 19 were misdiagnosed as anaemia and dystrophy, 18 as pituitary tumors, 10 as adiposities, 6 as myocarditis or pericardial effusion, 4 as Downs syndrome, 3 as hepatitis, 3 as amyasthenia, 3 as cerebral palsy, 2 as cystis thyrolingualis, and 2 as congenital megacolon. The duration of misdiagnoses ranged from 6 to 72 months. The clinical manifestations of these patients were complicated, involving multiple organs and systems.
CONCLUSIONSPH has complicated clinical manifestations and individual variations, and therefore can be easily misdiagnosed. Good knowledge, sufficient history-taking, and cautious physical examinations can help avoid misdiagnosis. Neonatal screening is helpful for diagnosis and treatment of congenital hypothyroidism.
Adolescent ; Child ; Child, Preschool ; Diagnostic Errors ; Female ; Humans ; Hypothyroidism ; diagnosis ; Infant ; Male
7.Endovascular therapy for small unruptured intracranial aneurysms
Hui HUANG ; Yong YANG ; Xiaoping PAN ; Weihua DENG ; Huameng HUANG ; Ze LI ; Hao ZHANG
International Journal of Cerebrovascular Diseases 2019;27(7):525-528
Objective To investigate the efficacy and safety of endovascular therapy for small unruptured intracranial aneurysms (sUIAs). Methods Patients with unruptured intracranial aneurysms who underwent endovascular therapy in the Department of Neurology, Guangzhou First People's Hospital from January 2008 to January 2018 were retrospectively included. According to the size of the aneurysms, they were divided into the sUIAs group (diameter <5 mm) and the non-sUIAs group (diameter ≥5 mm). Demographics, vascular risk factors, aneurysm characteristics, and treatment method, effectiveness, perioperative complications, and outcomes of endovascular therapy were compared between the two groups. Results A total of 80 patients with unruptured intracranial aneurysms were enrolled, including 33 patients with sUIAs (41.25% ) and 47 patients with non-sUIAs. The age of patients (51.1 ± 9.7 years vs. 61.2 ± 8.1 years; t=5.058, P<0.001), and the maximum diameter (3.6 ± 1.1 mm vs. 8.2 ± 3.2 mm; t=7.923, P<0.001) and neck width (3.1 ± 0.5 mm vs. 4.5 ± 2.5 mm; t=3.167, P=0.002) of aneurysms as well as the proportion of patients with wide-neck aneurysm (3.0% vs. 21.3% ; χ2 =7.213, P=0.007) and stent-assisted embolization (6.1% vs. 23.4% ; χ2 =4.285, P=0.038) in the sUIA group were significantly less than those of the non-sUIAs group. The embolization results, the perioperative complication rate and the good outcome rate were comparable between the two groups. Conclusion For sUIAs, endovascular therapy is effective and safe, comparable to endovascular therapy for non-sUIAs.
8.Clinical and epidemiological features analysis of pneumocystis jirovecii pneumonia in kidney transplant recipients
Ze SHEN ; Yangyang TIAN ; Zheng ZHOU ; Yu HUI ; Liangliang WANG ; Hao PAN ; Yuhua HUANG ; Linkun HU
Organ Transplantation 2023;14(4):570-
Objective To investigate clinical and epidemiological features of
9.Construction and identification of a vector inserted with complete genome of poliovirus strain Sabin I.
Hong-Hui SHEN ; Jun HOU ; Yan HU ; Bing-Ke BAI ; Zhi-Jie WANG ; Xiang-Hui YU ; Wei KONG ; Ze LIU ; Pan-Yong MAO
Chinese Journal of Experimental and Clinical Virology 2010;24(1):59-61
OBJECTIVETo develop a vector inserted with complete genome of poliovirus strain Sabin I.
METHODSThe 3 fragments of the complete genome of Sabin I was amplified and cloned to pEASY-T3 by molecular biological technology. These cloned pEASY-T3 were then digested by Restriction enzymes and ligated to pWSK29 step by step and identified.
RESULTSThe complete genome of poliovirus strain Sabin I was successfully cloned into vector pWSK29 with 9 nucleotide mutations.
CONCLUSIONThe complete genome plasmid was constructed and it provided a basis for further research of the function of Sabin I.
Cloning, Molecular ; Genetic Vectors ; genetics ; Genome, Viral ; Mutation ; Poliovirus ; genetics
10.Construction and identification of attenuated Salmonella which harboring enterovirus 71 VP1 gene.
Ze LIU ; Yan HU ; Hong-hui SHEN ; Shao-ping CAI ; Bing-ke BAI ; Rong GAO ; Sheng-dong LUO ; Yan-tao CHAI ; Pan-yong MAO
Chinese Journal of Experimental and Clinical Virology 2011;25(2):117-119
OBJECTIVETo develop attenuated Salmonella which harboring enterovirus 71 (EV71) VP1 gene.
METHODSThe plasmid which expressed VP1 protein of EV71 was constructed by gene recombination. Cellular expression was assessed by Western Blot analysis. The recombinant plasmid was then transformed into attenuated Salmonella SL7207.
RESULTSEV71 VP1 gene sequence was inserted into a eukaryotic expression plasmid VR1012. VP1 protein was detected by Western Blot analysis in the culture supernatant. And the attenuated Salmonella harbored the plasmid stable.
CONCLUSIONThe plasmid was constructed successfully and it can express effectively in vitro. The bacteria which harboring the plasmid were constructed successfully. This has provided a basis for further research of an oral EV71 vaccine.
Capsid Proteins ; genetics ; metabolism ; Enterovirus A, Human ; genetics ; Gene Expression ; Genetic Engineering ; Genetic Vectors ; genetics ; metabolism ; Salmonella ; genetics ; metabolism