1.Advances in research on RNA interference-related drugs for cancer treatment.
Chinese Journal of Oncology 2012;34(11):801-804
Animals
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Antineoplastic Agents
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therapeutic use
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Gene Silencing
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Genetic Therapy
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methods
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Humans
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MicroRNAs
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antagonists & inhibitors
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therapeutic use
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Neoplasms
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genetics
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therapy
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RNA Interference
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physiology
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RNA, Small Interfering
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antagonists & inhibitors
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therapeutic use
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RNA-Induced Silencing Complex
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metabolism
2.Extracelluar matrix stimulates neurite outgrowth of dorsal root ganglion neurons differently depending on whether extracted from degenerated or normal intervertebral disk
Chinese Journal of Tissue Engineering Research 2014;(7):1039-1044
BACKGROUND:Compared with the normal intervertebral disk, the density of nerve fibers and number of nerve endings and neuropeptides appear to be more in the degenerated intervertebral disk. However, this phenomenon does not occur in the normal y aged disk.
OBJECTIVE:To evaluate the axonal growth and induction of a painful neuropeptide and substance P using rat dorsal root ganglion neurons and degenerated human disc cells in vitro.
METHODS:The human intervertebral discs were harvested from patients with discogenic low back pain and normal people. And extracelluar matrix extracted from human degenerative intervertebral discs was cultured with rat dorsal root ganglion neurons. The promotion of axonal growth and induction of substance P of dorsal root ganglion neurons in extracted medium were evaluated through morphology observation and enzyme-linked immunosorbent assay, respectively.
RESULTS AND CONCLUSION:Compared with the normal group, the content of nerve growth factor in the degenerative group was significantly higher and the average length of neuritis was significantly longer in the experimental group (P<0.05). After intervention with anti-nerve growth factorβ, the average length of neuritis became remarkably shorter. The percentage of substance P-immunoreactive cells was significantly higher in the degenerative group compared with the normal group (P<0.001). Nerve growth factors that highly express in the extracellular matrix from the degenerative intervertebral dick can promote neurite outgrowth of dorsal root ganglion neurons and induce release of neuropeptides related to pain transmission.
4.Correlation between IL-1?,cagA of Helicobacter pylori and chronic gastritis
Wen QIAO ; Na LI ; Changshun LI ; Hui XUE
Journal of Xi'an Jiaotong University(Medical Sciences) 1982;0(04):-
0.05). Conclusion IL-1? has a higher value than cagA gene in predicting the prognosis of chronic gastritis.
5.Comparison of the efficacy of diffusion-weighted imaging and PET-CT in diagnosis of nasopharyngeal cancer.
Hui LI ; Chuan-miao XIE ; Xue-wen LIU
Chinese Journal of Oncology 2011;33(10):791-792
Adult
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Aged
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Bone Neoplasms
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diagnosis
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secondary
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Diffusion Magnetic Resonance Imaging
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methods
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Female
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Follow-Up Studies
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Humans
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Liver Neoplasms
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diagnosis
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secondary
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Male
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Middle Aged
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Multimodal Imaging
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methods
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Nasopharyngeal Neoplasms
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diagnosis
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Positron-Emission Tomography
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Tomography, X-Ray Computed
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Whole Body Imaging
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methods
6.Influence of age factor on treating cutaneous hemangioma with 90 Sr-90Y applicator
Jine XUE ; Bing WEN ; Changyin WANG ; Shuisheng ZHANG ; Hui GUO
Chinese Journal of Medical Aesthetics and Cosmetology 2013;(2):114-117
Objective To explore the influence of age factor on the treatment of cutaneous hemangioma with (90Sr-90Y) applicator.Methods A total of 224 babies and children of different ages with cutaneous hemangioma were treated by using 90Sr-90 Y applicator.Then,the relation between their therapeutic effects and ages were analyzed respectively.Results The differences in the therapeutic effect between group of one month to less than one year and group of one to less than five years,and group of one month to less than one year and group of five to ten years,and between group of one to less than five ages and group of five to ten years (P<0.05),were statistically significant.With an increase of the age,the recovery rate gradually decreased,but their effective rate,improvement rate and ineffective rate increased.In the 199 well-healed or effective patients,the differences in the distribution of treatment course between group of one month to less than one year and group of one to less than five years,and group of one month to less than one year and group of five to ten years,were statistically significant (P<0.05); but the difference in the distribution of treatment course between group of one to less than five ages and group of five to ten years was not statistically significant (P>0.05).The number of treatment course presented an increased tendency with an increase of the age for patients.Conclusions The age of patients is a factor influencing the therapeutic effect on cutaneous hemangioma with 90 Sr-90Y applicator.The younger the patients,the better their therapeutic effects,the shorter their courses of treatment,and the smaller the adverse reaction of beta ray.
7.Relationship between cerebral infarction and nosocomial pneumonia with coal workers' pneumoconiosis.
Wen-shou XUE ; Feng-rui ZHAO ; Hui ZHANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2005;23(5):378-379
Aged
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Aged, 80 and over
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Anthracosis
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complications
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microbiology
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Cerebral Infarction
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etiology
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Cross Infection
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complications
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Humans
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Male
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Middle Aged
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Pneumonia
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complications
8.Summary of Hui prescriptions for treating cough.
Wen-Jin ZHANG ; Ting XUE ; Xue-Yan FU ; Xin-Hui ZHANG
China Journal of Chinese Materia Medica 2015;40(1):154-159
By using the method of philology, 65 Hui prescriptions for treating cough were been collected to compare Arabic and Chinese names of pennisetum, anemarrhenae, honey, pease, white mustard, perilla and towel gourd stem. The Countif function in Microsoft Excel 2007 was used to count frequency of drugs in the prescriptions and summarize eight common Hui medicine for treating cough, namely sugar, honey, almond, fritillaria, liquorice, orange peel, white mulberry root-bark and lily. According to the commonly used drugs, philological studies and theories of Hui medicines, pathology and therapy of Hui medicines for treating cough were preliminarily inferred. In this study, 35 practical prescriptions and 30 simple and convenient Halal dietary prescriptions were summarized from collected prescriptions according to relevant literatures. On the basis of the long-lasting unique dietary therapy culture developed for Hui people, the simple and practical dietary prescriptions were defined according indications, therapy, prescription name and composition, and eight types of drug-admixed foods were summarized to relieve pains and improve health awareness and quality of life. Meanwhile, this study could also enrich and perfect the prescriptions, provide new ideas for improving health of patients, and lay a certain realistic foundation for further study of Hui medicines.
China
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ethnology
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Cough
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drug therapy
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ethnology
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Drug Prescriptions
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Drug Therapy, Combination
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Drugs, Chinese Herbal
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administration & dosage
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chemistry
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Humans
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Medicine, Chinese Traditional
9.Cancer-related proteins discovery of uveal melanoma with comparative proteomic analysis
Mei-Xia KANG ; Wen-Bin WEI ; Xue-Hui SHI ; Lei CUI ;
Ophthalmology in China 1993;0(04):-
Objective To identify and characterize uveal melanoma associated protein variants with two-dimensional electrophore- sis and mass spectrometry.Design Experiment study.Participants 4 cases of specimens of uveal melanoma and 4 cases of normal con- tributed uveal tissue.Methods Proteins from uveal melanoma and normal urea were separated with two-dimensional eleetrophoresis (2-DE)and visualized with Coomassie G-250.Gels were analyzed by Image Master 5.0 software.The mass spectra were measured by matrix-assisted laser desorption/ionizatian time-of-flight mass spectrometry(MALDI-TOF MS)and searched against NCBI database using Mascot software.Main Outcome Measures Differential proteins.Results A set of 30 proteins were differentially expressed in uveal melanoma compared to nomal urea.Twenty-four types of protein only expressed in uveal melanoma.Five types of protein were up-regu- lated and 1 type of one down-regulated.These proteins can be subdivided into groups according to cellular function,such as enzyme, signal transduction,signal regulation,cytoskehton,immune,etc.Conclusions There is significant difference in protein profilings be- tween uveal melanoma and normal uvea.The differentially expressed proteins may be associated with the development of uveal melanoma.
10.RAPD analysis of nine populations of medicinal mulberry cultivated in Xinjiang
Daxu FU ; Hui ZHANG ; Wen CHEN ; Xue SU ; Kun SUN ; Jiakuan CHEN ;
Chinese Traditional and Herbal Drugs 1994;0(09):-
Object To study the inherited relationships among nine medicinal mulberry populations cultivated in different regions of Xinjiang at DNA level Methods DNA of all populations was amplified by ten random primers from 100 ramdom primers, the polymorphic bands of RAPD were counted And the results of populations were analyzed by clustering analysis NTSYS PC software Results A total of 108 bands was obtained, 91 of total bands (84 26%) was polymorphic The results indicated that there were apparent and abundant genetic variations in Morus L of Xinjiang Besides, eight specific bands of M nigra were obtained Conclusion The genetic relationship among medicinal resources plants of mulberry in Xinjiang indicats by the RAPD analysis to be consistent with their traditional classifications in the main