Objective To study the relationship among hydrops fetalis(over 28 gestational weeks),Mirror syndrome and preeclampsia(PE). Methods Clinical data of 13 cases of hydrops fetalis were analyzed and relative publications were reviewed. Results Eight out of the 13 cases were diagnosed as PE,and 5 were Mirror syndrome.Serious maternal complications occurred in all cases with either Mirror syndrome or PE. ConclusionsFetaland placental hydrops was closely related with maternal symptoms.Clinicians should be aware of this condition and detect Mirror syndrome in time so as to prevent its progress to PE.However,the pathogenic mechanism remains to be fully elucidated.More attention should be paid to both mothers and the hydrops fetalis.

Cyclooxygenase (COX) is a crucial enzyme in the biosynthesis of prostaglandins.There are two COX isoforrns:COX-1 and COX-2.Recently it is demonstrated that there is a close relationship of COX-2 with the occurrence,development and metabasis of tumor; COX-2 inhibitor is hoping to be a new target in tumor therapy.The article overviews many progresses of COX-2 about its expression,modulation and mecha-nism of carcinogenesis in cholangiocarcinoma in order to explore the prospect of the COX-2 inhibitors in cholangioearcinoma treatment.

0.05);Compared with the control group, the time of first stage(403?135) min and the total time of labor(455?148) min were shorter ( P

Animals ; Arsenic Poisoning ; DNA Damage ; Gene Expression ; Humans

Background and purpose:The mechanism of vinorelbine is inhibition of microtubule protein assembly and inducetion of the disaggreation of microtubles;where as docetaxed promotes the assembly of microtuble protein and inhibits normal physiological disaggreation of tubulin.We studied the curative effect and toxicity of combination of chemotherapy with navelbine(NVB) plus paclitaxel in the treatment of advanced breast cancer.Methods:Forty-two pathologically and cytologically proved cases of advanced breast cancer were treated with intravenous infusion of navelbine 25mg/m~2 on d1 and d8,paclitaxel 175mg/m~2 by 3-hour continuous infusion on d1.Interval between each cycle was 21 days and the clinical response and the toxicity were assessed after 2~4 cycles.Results:The overall response rate(RR) for the whole group of patients was 66.7% with 16.7% complete response(CR).In the first time chemotherapy patients,the RR was 72.2% with 27.2% CR;while in those with prior chemotherapy,an RR as high as 62.5% with 8.3% CR was also obtained.The 2-and 4-year survival rates was 40.5% and 21.4%,the median remission period was 8 months,the median overall survival duration was 18 months.The major side effects include leukopenia,hairloss,milieu phlebitis.Conclusions:The combination chemotherapy with navelbine and paclitaxel in treatment of advanced breast cancer is effective and the side effects could be tolerated.

Objective:To establish a method for the determination of salicylic acid in the compound sulfur ointments by ultra-per-formance liquid chromatography (UPLC). Methods:An Agilent ZORBAX SB-C18(250 mm ×4.6 mm,5 μm)column was used, the mobile phase was methanol-0. 1 mol·L-1 sodium dihydrogen phosphate (30∶70), the detection wavelength was 231nm, the column temperature was 35℃, the flow rate was 1. 0 ml·min-1 and the injection volume was 10μl. Results:The linear range of salicylic acid was 11. 96-59. 80 μg·ml-1(r=0. 999 9), and the average recovery was 99. 72%(RSD=1. 28%,n=9). Conclusion:The method is accurate, stable and specific, and suitable for the determination of salicylic acid in the compound sulfur ointments.

Objective: To improve the database of medical equipment archives system and manage medical equipment more scientifically and efficiently. Methods:According to the needs of medical equipment management, the problems of medical equipment archives system would be analyzed and addressed. Results:In recent medical equipment archives system, the database of usage rate, cost-effectiveness, maintenance costs and property management should be improved. Conclusion:The improved archives system could provide reliable basic data and multi-faceted sharing for medical equipment dynamic management.

Objective To investigate the effect of Danzhijiangtang capsule on serum,fat in type 2 diabetic rats.Methods The model of type 2 diabetes mellitus rats were established by injecting small does streptozotocin(STZ)into abdomen and feeding high sucrose-fat diet.All the rats were divided randomly into five groups.The level of blood glucose,serum insulin,insulin sensitivity index,blood fat(triglyceride, cholesterol,high-density lipoprotein,low-density lipoprotein),free fatty acid after treated were examined. Results Danzhijiangtang capsule could decrease the level of blood fat.Conclusion Danzhijiangtang capsule could improve the blood fat in type 2 diabetic rats.

Objective:To study new dosage form of Bingpeng powder referring to oversea patent. Methods: To disperse Bingpeng powder, adhesive and viscosity builders (such as gelatin, carboxymethylcellulose, hypromellose or carbomer), nonionic emulsifier (gluceryl monostearate) and white vaseline into liquid paraffin, stir to attain paste. The formulation was screened by adhesive strength, shape keeping characteristic and water asorbing value. Results: The better formulation: Bingpeng powder 5.0g, hypromellose 21.0g, carbomer 14g, gluceryl monostearate 3.0g, white vaseline 7.0g, liquid paraffin to 100.0g; the paste getting rabbits' artificial ulcers healed more quickly than powder does. Conclusion: The paste is applied more expediently and more effective for oral ulcer.

Objective To investigate the change of serum prealbumin (PA) and C-reactive protein (CRP) in burn patients and its clinical significance.Methods Sixty eight cases of burn patients were divided into two groups,group Ⅰ [n=38,with total burn surface area less than 15% of total body surface area (TBSA)] and groupⅡ(n=30,with total burn surface area more than 50% of TBSA). Thirty healthy people were set as healthy control group. Particle enhanced immunoturbidimetic assay was applied to detecting the serum levels of PA and CRP for all subjects on the day 1 after burns.Results The CRP level was much higher and serum level of PA was much lower in group Ⅱ than that of group Ⅰ,respectively. There existed significant negative correlation between PA and CRP level.Conclusion The level of serum PA decreases significantly along with total burn surface area expansion. PA can be used as a sensitive marker for estimation of inflammation degree after burns.