Cyclooxygenase (COX) is a crucial enzyme in the biosynthesis of prostaglandins.There are two COX isoforrns:COX-1 and COX-2.Recently it is demonstrated that there is a close relationship of COX-2 with the occurrence,development and metabasis of tumor; COX-2 inhibitor is hoping to be a new target in tumor therapy.The article overviews many progresses of COX-2 about its expression,modulation and mecha-nism of carcinogenesis in cholangiocarcinoma in order to explore the prospect of the COX-2 inhibitors in cholangioearcinoma treatment.

0.05);Compared with the control group, the time of first stage(403?135) min and the total time of labor(455?148) min were shorter ( P

Objective To study the relationship among hydrops fetalis(over 28 gestational weeks),Mirror syndrome and preeclampsia(PE). Methods Clinical data of 13 cases of hydrops fetalis were analyzed and relative publications were reviewed. Results Eight out of the 13 cases were diagnosed as PE,and 5 were Mirror syndrome.Serious maternal complications occurred in all cases with either Mirror syndrome or PE. ConclusionsFetaland placental hydrops was closely related with maternal symptoms.Clinicians should be aware of this condition and detect Mirror syndrome in time so as to prevent its progress to PE.However,the pathogenic mechanism remains to be fully elucidated.More attention should be paid to both mothers and the hydrops fetalis.

Animals ; Arsenic Poisoning ; DNA Damage ; Gene Expression ; Humans

Background and purpose:The mechanism of vinorelbine is inhibition of microtubule protein assembly and inducetion of the disaggreation of microtubles;where as docetaxed promotes the assembly of microtuble protein and inhibits normal physiological disaggreation of tubulin.We studied the curative effect and toxicity of combination of chemotherapy with navelbine(NVB) plus paclitaxel in the treatment of advanced breast cancer.Methods:Forty-two pathologically and cytologically proved cases of advanced breast cancer were treated with intravenous infusion of navelbine 25mg/m~2 on d1 and d8,paclitaxel 175mg/m~2 by 3-hour continuous infusion on d1.Interval between each cycle was 21 days and the clinical response and the toxicity were assessed after 2~4 cycles.Results:The overall response rate(RR) for the whole group of patients was 66.7% with 16.7% complete response(CR).In the first time chemotherapy patients,the RR was 72.2% with 27.2% CR;while in those with prior chemotherapy,an RR as high as 62.5% with 8.3% CR was also obtained.The 2-and 4-year survival rates was 40.5% and 21.4%,the median remission period was 8 months,the median overall survival duration was 18 months.The major side effects include leukopenia,hairloss,milieu phlebitis.Conclusions:The combination chemotherapy with navelbine and paclitaxel in treatment of advanced breast cancer is effective and the side effects could be tolerated.

Adult ; Cord Blood Stem Cell Transplantation ; adverse effects ; Cytomegalovirus ; Cytomegalovirus Infections ; complications ; Female ; Hemolysis ; Humans

Objective To investigate the change of serum prealbumin (PA) and C-reactive protein (CRP) in burn patients and its clinical significance.Methods Sixty eight cases of burn patients were divided into two groups,group Ⅰ [n=38,with total burn surface area less than 15% of total body surface area (TBSA)] and groupⅡ(n=30,with total burn surface area more than 50% of TBSA). Thirty healthy people were set as healthy control group. Particle enhanced immunoturbidimetic assay was applied to detecting the serum levels of PA and CRP for all subjects on the day 1 after burns.Results The CRP level was much higher and serum level of PA was much lower in group Ⅱ than that of group Ⅰ,respectively. There existed significant negative correlation between PA and CRP level.Conclusion The level of serum PA decreases significantly along with total burn surface area expansion. PA can be used as a sensitive marker for estimation of inflammation degree after burns.

Adolescent ; Adult ; Chronic Disease ; Female ; Hexanes ; poisoning ; Humans ; Occupational Diseases ; therapy ; Retrospective Studies ; Treatment Outcome ; Young Adult

Liver fibrosis can be caused by chronic liver injury arising from various etiological factors.The activation of the hepatic stellate cell(HSC) is the central event in liver fibrosis,the apoptosis of which was the initiating factor for the reversal process.The apoptosis of HSC is very complicated.The signaling pathways lack of enough research in regulating and controlling and activating HSC's apoptosis.The apoptosis pathways as known currently mainly include mitochondrial pathway,death receptor pathway and non-death receptor pathway.Based on these signaling pathways,selectively inducing cell death of activated HSCs is becoming the new antifibrotic treatment.This review focuses on the new progress of HSC's apoptosis signaling pathways,and summarizes the drugs that have the effect of inducing HSC apoptosis.

AIM: To investigate the influence of diethylstilbestrol on metabolism and antioxidative functions in old castrated female rats in order to elucidate the physiological and pharmacological effects of estrogen therapy in climacteric. METHODS: The old female rats had been castrated, liver drug-metabolizing enzyme activities and antioxidative indexes were measured in rats treated with and without diethylstilbestrol (100 ?g?kg -1 , qd?40 d, ig). RESULTS: The activities of microsomal NADPH-Cyt C reductase, benzphetamine N-demethylase, aminopyrine N-demethylase, glutathione S-transferase, and the contents of microsomal cytochrome P450, cytochrome b_5 and homogenate glutathione remarkable decreased in the liver of castrated female rats. Meanwhile, an increase of liver malondialdehyde content was also observed. Treatment with diethylstilbestrol could reverse the changes of above indices except for cytochrome b_5. CONCLUSION: The decreased metabolism and antioxidative functions are related to the lower level of estrogen in old castrated female rats. Estrogen plays a significant role in keeping normal metabolism and antioxidative capacities of the liver.