2.Neonatal ulcerative colitis in a case.
Hui ZHANG ; Gui-nan LI ; Xin-hui LIU
Chinese Journal of Pediatrics 2009;47(5):393-394
3.Progress on the characteristics of gene variants in sporadic medullary thyroid cancer
Han ZHANG ; Daqi ZHANG ; Nan LIANG ; Hui SUN
Chinese Journal of Endocrine Surgery 2021;15(2):205-207
Medullary thyroid carcinoma (MTC) is a rare endocrine tumor characterized by high malignancy, early metastasis and easy recurrence. Sporadic medullary thyroid carcinoma (sMTC) is the main pathological type of MTC, accounting for about 75%. Compared with hMTC which has more clear germline mutations in the RET gene, the pathogenesis of sMTC is still unclear. We mainly retrospectively reviewed the characteristics of gene variants and the associations of their gene variants with tumor risk, including RET gene variants, somatic RAS gene variants, CDKN gene variants and other gene variants, aiming to provide novel directions for the evaluation of patients in terms of etiology.
4.Urotensin II and atherosclerosis.
Li-Fang ZHANG ; Wem-Hui DING ; Yuan-Nan KE
Chinese Journal of Cardiology 2007;35(5):491-493
5.Analysis and strategy on the less approved results of lumbar discectomy
Nan-Min JI ; Wei-Tao YAO ; Hui ZHANG ;
Chinese Journal of Orthopaedics 2000;0(11):-
Objective To study the relationship of surgical procedures with clinical effect in herniat-ed lumbar disc in order to improve operative methods and obtain a better outcome.Methods Retrospec-tive analysis was carried out in7235patients with herniated lumbar disc,who had been operated by removal of nucleus pulposus using small incision and fenestration in our hospital since1983,313cases of whom re-ceived second operation because of postoperative complications.There were187males and126females aging from27to62years(mean,45.8years),the incidence of morbidity was4.32%.During the same period,552patients,who had less approved operative result primarily treated in other hospitals,were admitted to our hospital.There were317males and235females aging from31to64years(mean,46.0years).Results The postoperative complications could be divided into short term(within1month after operation)and mid-dle to long term(more than1month after operation)groups.The total446cases with short term compli-cation were133cases primarily treated in our hospital and313cases in other hospital,including of re-herni a-tion or incomplete nuclear extirpation in77treated with second operation,discitis in106treated with con-servative therapy for 67and second operative management for 39,canal hematoma compression in76treated surgi cally,multi-level herniation and leakage in21and mislocalization in59re-operated,injury of nerve root or cauda equina in85treated with nerve exploration,release and anastomosis,residual materials in canal in17with removal of foreign body,venous thrombus in2,and arachnoiditis in3.The total424cases with middle to long term complications were185cases primarily treated in our hospital and239cases in other hospitals,including of nerve root adhesion in159,recurred disc herniation in122,segmental instability in81,and ia-trogenic spinal stenosis in62.Conclusion Many factors may influence the outcome of herniated lum bar disc which can be abolished by sufficient preparation,careful operation and proper managememt.
6.DETERMINATION OF TOTAL BODY FAT BY WATER DISPLACEMENT METHOD
Qing-Hui YANG ; Bing-Zhang DUAN ; Ya-Nan JIANG ;
Acta Nutrimenta Sinica 1956;0(02):-
Body fat of 12 male adults were measured by water displacement me-thod(density method) at every morning for 5 successive days. The standard deviation of single observation was 0.29kg calculated by mean residual lung volume method. It was significantly lower than the value (0.5kg) calculated by the ordinary method (p
7.Relationship of haplotypes of FgBbeta-1420G/A -993C/T, and BsmAIG/C with functional expression and cerebral infarction.
Nan-nan ZHANG ; Xiao-dong YUAN ; Jian-hui XU ; Hong-liang DENG ; Shu-juan WANG
Chinese Journal of Applied Physiology 2012;28(3):218-220
Aged
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Case-Control Studies
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Cerebral Infarction
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blood
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genetics
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Female
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Fibrinogen
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genetics
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metabolism
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Haplotypes
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Humans
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Male
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Middle Aged
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Polymorphism, Genetic
8.Diagnosis and treatment characteristics of radioactive optic neuropathy
Yan, ZHANG ; Hong-Yang, LI ; Chun-Xia, PENG ; Nan-Nan, GUO ; Shi-Hui, WEI
International Eye Science 2014;(6):1095-1099
AIM:To explore the diagnosis and treatment methods of radioaction-induced optic neuritis ( RION) through the clinical dates of 17 patients.
METHODS: It was a retrospective case series study. From August 2008 to October 2013, 17 cases (24 eyes) of Rion clinical dates from Chinese PLA General Hospital were studied. The diagnosis methods including visual acuity, pupil, fundus, visual field, fundus fluorescein angiography (FFA), visual electrophysiological testing, and head MRI. To analysis the clinical date of patients with diagnosis of RION by statistical description.
RESULTS: The deterioration degree of vision: 13 eyes were classified as Ⅳ, 9 eyes as Ⅲ, 2 eyes as II. Ten eyes RAPD ( + ) , visual electrophysiology is extinguished. The retina of 5 eyes showed flame hemorrhages and cotton wool spots exudation. Optic nerve head edema in one eye. T1 - weighted MRI enhanced in 19 eyes which showed optic nerve of the intracranial and intratubal segments abnormal changed, optic chiasm and pituitary stalk signal abnormalities and enhancement of the optic nerve. Tortuous optic nerves and rough edges were observed in 5 eyes. Treatment effect: 4 eyes of visual acuity improved, 1 eye from blindness to light perception,1 eye from 0. 08 to 0. 2, 1 eye from 0. 4 to 0. 6,1 eye from 0. 04 to 0. 15, the rest of the cases did not see any improvement.
CONCLUSION: The unique clinical manifestation of RION can provide objective basis for clinical diagnosis in time, but there have not been proven any effective treatments.
9.ILs-HPLC simultanesous determination of five alkaloids in phellodenddri chinensis cortex.
Xin-Yi JIANG ; Hui-Fen ZHANG ; Sheng-Nan WANG ; Xiao-Hui CHEN
China Journal of Chinese Materia Medica 2014;39(19):3808-3812
A RP-HPLC method was established for simultaneous determination of phellodendrine hydrochloride (PH1), magnoflorine hydrochloride (MH), jatrorrhizine hydrochloride (JH), palmatine hydrochloride (PH2) and berberine hydrochloride (BH) in Phellodendri Chinensis Cortex by using ionic liquids as mobile phase additives. The separation was performed on a Kromasil C18 (4.6 mm x 250 mm, 5 μm) coupled with ultraviolet (UV) detection. The effect of extraction solvent, detection wavelength, length of alkyl chain on different imidazolium ionic liquids and concentration of ionic liquids on the separation and determination of alkaloids were investigated. Ionic liquid, [BMIm] BF4, can obviously improve the resolution and peak shape. This ILs-HPLC method is simple, rapid, and reliable, which can be used for determination of alkaloids in Phellodenddri Chinensis Cortex.
Alkaloids
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analysis
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Chromatography, High Pressure Liquid
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Drugs, Chinese Herbal
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analysis
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Phellodendron
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chemistry
10.Effects of MEK signaling inhibitor on the growth of human pacreatic cancer cell lines and the expression of cell cyde associated genes
Xia WANG ; Hui WANG ; Nan JIANG ; Sanhong LIANG ; Wen Lü ; Xiao ZHANG ; Xiaofeng ZHANG
Chinese Journal of Pancreatology 2011;11(4):259-262
Objective To examine the effects of the MEK inhibitor on human pancreatic cancer cells, and to explore the molecular mechanisms. Methods Human pancreatic cancer cell lines CFPANC1, PANC1 and MiaPaCa2 were treated with MEK inhibitor PD98059 or DMSO, the sensitivity was analyzed by an MTT assay, and cell cycle distribution was evaluated by flow cytometry( FCM), The transcriptional level and protein expression of tumor suppressor genes were detected by real-time RT-PCR and western blot respectively. DNA methyltransferase (Dnmt)1, 3a and 3b were also assayed by western blot, The methylation status of the promoter of the p16INK4A gene was assayed by methylation-specific PCR (MSP). Results PD98059 inhibited to various degrees the growth of three pancreatic cancer cell lines, accompanied by G0-G1 cell cycle arrest. PD98059 up-regulated the expression of p16INK4a, p21WAF1, p27KIP1 mRNA, demethylated the hypermethylation status of p16INK4a gene promoter, and decreased Dnmtl and Dnmt3b in CFPANC1 and PANC1 cell lines. PD98059 only increased the expression of p27KIP1, while the changes of p16INK4a, p21WAF1 and Dnmt were less marked in MiaPaCa2 cell line. Conclusions MEK inhibitor PD98059 down-regulate the activation of Dnmt and up-regulate tumor supress genes, along with the inhibition of cell proliferation and cell cycle progression.