1.Development and Application of Metabonomics in Forensic Toxicology.
Journal of Forensic Medicine 2015;31(3):219-226
Metabonomics is an important branch of system biology following the development of genomics, transcriptomics and proteomics. It can perform high-throughput detection and data processing with multiple parameters, potentially enabling the identification and quantification of all small metabolites in a biological system. It can be used to provide comprehensive information on the toxicity effects, toxicological mechanisms and biomarkers, sensitively finding the unusual metabolic changes caused by poison. This article mainly reviews application of metabonomics in toxicological studies of abused drugs, pesticides, poisonous plants and poisonous animals, and also illustrates the new direction of forensic toxicology research.
Animals
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Biomarkers
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Forensic Toxicology/methods*
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Humans
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Metabolomics/methods*
2.Development and Application of Metabonomics in Forensic Toxicology
Journal of Forensic Medicine 2015;(3):219-226
Metabonom ics is an im portant branch of system biology follow ing the developm ent of ge-nom ics, transcriptom ics and proteom ics. It can perform high-throughput detection and data processing with multiple param eters, potentially enabling the identification and quantification of all sm all m etabolites in a biological system . It can be used to provide com prehensive inform ation on the toxicity effects, toxi-cological mechanisms and biom arkers, sensitively finding the unusual m etabolic changes caused by poi-son. This article mainly review s application of m etabonom ics in toxicological studies of abused drugs, pesticides, poisonous plants and poisonous anim als, and also illustrates the new direction of forensic toxi-cology research.
3.Comparison of Electrogastrogram and Gastroscopy in 136 Children with Gastric Disease
Journal of Applied Clinical Pediatrics 2004;0(07):-
Objective To study and evaluate the consistency and diagnostic value of electrogastrogram(EGG) and gastroscopy in children′s gastrosis diagnosis.Methods A total of 136 children were checked with gastroscopy and EGG during the same period,then compared the diagnostic accordance rate with 2 ways,and analyzed the characteristics of EGG.Results EGG showed certain characteristics in different gastrosis.Diagnosis of EGG in the group of functional illness was consistence with gastroscopy at 95.8%;others were less than 40%.Conclusion EGG can be used as a method of special value to diagnose children′s functional gastrosis and a screening means in general gastrosis.
4.Electrogastrographic parameters from 40 healthy subjects 6 to 14 years of age.
Yan YANG ; Hui-min YAN ; Ming LI
Chinese Journal of Pediatrics 2005;43(9):697-698
Adolescent
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Child
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Electromyography
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Female
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Humans
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Male
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Stomach
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physiology
5.Risk Factors of Recurrent Stroke and Taking Nursing Measure in the Elderly
Min ZHU ; Fengyun YAN ; Hui JI
Chinese Journal of Rehabilitation Theory and Practice 2008;14(8):799-800
Objective To take nursing measure through analysis on the risk factors of recurrent stroke in the aged.Methods Total 96 subjects were analyzed retrospectively.The risk factors were compared on the urban and the rural through analyzing their clinical characteristics.Results There were more diabetes mellitus and blood lipid disorder and obesity in urban than those in rural.There was also a difference in hypertension between the urban and the rural.Conclusion The recurrence of stroke in the aged is owing to many factors.The different measure should be taken by different reasons.
6.Influence of different kinds of infusion solutions during renal transplantation on blood glucose levels in children.
Min-Hui DAI ; Kun YAN ; Can LU
Chinese Journal of Contemporary Pediatrics 2011;13(7):595-597
Adolescent
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Blood Glucose
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analysis
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Female
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Humans
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Kidney Transplantation
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Male
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Sodium
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blood
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Sodium Chloride
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administration & dosage
7.Analysis on macular choroidal thickness of patients with myopic choroidal neovascularization
Yan, QIU ; Zong-Hua, WANG ; Hui-Min, ZHANG ; Yan, ZHANG
International Eye Science 2015;(5):906-908
? AlM: To examine choroidal thickness and its relationship with axial length and spherical equivalent by spectral domain optical coherence tomography ( SD -OCT ) in patients with myopic choroidal neovascularization ( mCNV) .
?METHODS: We prospectively recruited 30 cases of mCNV in Beijing Anzhen Hospital from October 2010 to December 2014. SD-OCT was used to measure choroidal thickness subfoveally and at 1. 5mm superiorly, inferiorly, nasally and temporally ( SFCT, SCT1. 5mm , lCT1. 5mm , NCT1. 5mm , TCT1. 5mm ) . Paired t- test was conducted to assess the difference of spherical equivalent, axial length and choroidal thickness between mCNV group and controls. Logistic regression analysis was performed to evaluate the correlation between spherical equivalent, axial length, choroidal thickness and mCNV.
?RESULTS: The difference of spherical equivalent and axial length between mCNV group and controls was not significant (P>0. 05). lnferior was decreased in mCNV group compared with controls (140. 85±33. 46μm vs 168. 95±45. 36μm). The difference was significant (P=0. 008). Logistic regression demonstrated that decreased choroidal thickness ( lCT1. 5mm ) at inferior location was associated with mCNV (OR=2. 12;95%CI 1. 35~3. 28;P=0. 02).
?CONCLUSlON: The decrease of lCT1. 5MM may be one of the risk factors of mCNV.
10.Effect of Zhuyun Capsule on Expression of Ovarian Cytokine of Polycystic Ovary Syndrome Rats
Yan-Qiao LIU ; Hui-Min DANG ; Run-Xia LIU ;
Journal of Traditional Chinese Medicine 1993;0(05):-
Objective To observe the effect of Zhuyun Capsule(Pregnant-promoting Capsule)on serum sex hormone and expres- sion of ovarian cytokine of polycystic ovary syndrome(PCOS)rats.Methods Progestogen plus human chorionic gonadotrophin (HCG)was adopted to make PCOS rat models.Totally 40 SD rats were randomized into control group,PCOS model group,Zhuyun Capsule group,and clomiphene citrate group with 10 in each.Radioimmune assay(RIA)was used to measure the sex hormone and immunohistochemical test was done to measure the expression of tumor necrosis factor-?(TNF-?)of ovarian tissue,insulin-like growth factors-1(IGF-1),and leukemia inhibitory factor(LIF)to analyze the relations among these factors.Results Zhuyun Capsule could reduce greatly serum testosterone(T)and luteinizing hormone(LH),decrease expression of TNF-?and IGF-1,but increase expres- sion of LIF.Conclusion Zhuyun Capsule could regulate endocrine function and expression of ovarian cytokine to improve gonad func- tions of PCOS rats and to promote the maturation of follicle and ovulation.