3.Effect of Edaravone Combined with Plantula Ixeridis Sonchifoliae on Relieving Neurologic Impairment Symptoms of Patients with Acute Cerebral Infarction
Zerong ZHENG ; Min HUANG ; Hui LIU ; Jianqiang CHEN
Journal of Guangzhou University of Traditional Chinese Medicine 2001;0(03):-
Objective To observe the effect of edaravone combined with Plantula Ixeridis Sonchifoliae(PIS) on relieving neurologic impairment symptoms of patients with acute cerebral infarction(ACI).Methods Ninety-two ACI patients were equally randomized into the treatment group and the control group.The two groups were given routine western medical treatment such as use of aspirin and neurotrophic drugs,and decreasing intracranial pressure and symptomatic treatment for large-size cerebral ischemia.Additionally,the treatment group received intravenous injection of edaravone injection plus PIS injection,and the control group received PIS injection.Fourteen days constituted one treatment course,and the treatment lasted 2 courses.The score of neurologic impairment was evaluated with European Stroke Scale(ESS),and the score of activities of daily life(ADL) was observed before treatment,and after one and two treatment course(s).The adverse reaction was recorded during the treatment.Results At the end of the first treatment course,the scores of ESS and ADL were improved in both groups(P0.05).At the end of the second treatment course,the scores of ESS and ADL were markedly improved in both groups(P
4.Expression and clinical significance of serum response factor and vascular endothelial growth factor receptor 2 in gastric carcinoma
Min ZHAO ; Hui ZHANG ; Ying ZHOU ; Jiangmei HUANG ; Ruiji LIU
Cancer Research and Clinic 2016;28(2):112-115
Objective To investigate the expression and clinical significance of serum response factor (SRF) and vascular endothelial growth factor receptor (VEGFR2) in gastric carcinoma. Methods SABC immunohistochemical method was used to determine the expressions of SRF and VEGFR2 in 50 cases of gastric carcinoma, 50 cases of surgery incisal edges and 29 cases of lymph node metastasis focus. Results The detection positive rates of SRF and VEGFR2 in gastric carcinoma were 52.00 % (26/50) and 60.00 %(30/50), respectively, which were significantly higher than those in the normal gastric mucosa [16.00 % (8/50) and 10.00 % (5/50), respectively] (P< 0.05), with no statistical difference with metastiatic lymph node [65.52 % (19/29) and 72.41 % (21/29), respectively]. In the gastric carcinoma group, the expression of SRF was relevant with depth of invasion and lymph node metastasis (P<0.05). The expression of VEGFR2 was not related to age, gender and tumour size (P>0.05), but closely correlated to differentiation degree, invasion depth and lymph node metastasis (P<0.05). The expressions of SRF and VEGFR2 in the gastric carcinoma were positively correlated (r= 0.594, P< 0.05). Conclusion Overexpressions of SRF and VEGFR2 in gastric carcinoma can be regarded as the poorly prognostic markers and play an important role in invasion and metastasis of gastric carcinoma.
5.Bioavailability and bioequivalence of erythromycin ethylsuccinate granules in healthy volunteers
Gui-Xiong ZENG ; Guo-Ping ZHONG ; Xue-Ding WANG ; Li-Hui HUANG ; Min HUANG ;
Chinese Journal of Infection and Chemotherapy 2006;0(04):-
Objective To study the bioavailability and bioequivalence of erythromycin ethylsuccinate granules in healthy male volunteers.Methods In a randomized two-period crossover study,20 healthy male volunteers received single 500 mg test and reference formulations of erythromyein ethylsuccinate granules.The plasma concentrations of erythromycin were assayed by microbiological method.Results The parameters of test and reference preparations were as follows:T_(max)(0.86?0.22)and (0.80?0.13)h,C_(max)(2.13?0.64)and(2.16?0.61)mg/L,t_(1/2)(2.04?0.2)and(1.97?0.4)h,AUC_(0-t)(4.96?1.73)and(4.63?1.52)mg?h/L,respectively.There was no significant difference between the two preparations.The rela- tive bioavailahility of the test granules was(109.1?22.8)%.Conclusions The two preparations of erythromycin ethylsucci- nate granules are bioequivalent.
6.Time trends and age-related characteristics of cardio-cerebrovascular deaths in Hunan.
Hui MING ; Hui-biao XIANG ; Min-zhu HUANG ; Guang-chun LI
Chinese Journal of Cardiology 2010;38(6):558-561
OBJECTIVETo investigate the time trends and age-related characteristics of mortality and disease burden for cardiocerebrovascular diseases (CVD) in Hunan, China during three periods (1973-1975, 1990-1992 and 2004-2005).
METHODSThe cardiocerebrovascular death data of Hunan residents were collected by three national retrospective sample surveys of death. Cause-specific mortality, proportion, years of potential life lost (YPLL) and associated indicators were identified in the population of Hunan in above mentioned three periods. Time trends of age-specific mortality rate were assessed by fitting curvilinear regression lines and the increase rates of mortality with age were analyzed in each period.
RESULTSThe standard all-cause mortality of residents in Hunan decreased (chi2 = 189.947, P < 0.001, chi2 = 54.201, P < 0.001; chi2 = 27,396.898, P < 0.001) while the standard mortality for CVD increased (chi2 = 54.201, P < 0.001; chi2 = 27,396.898, P < 0.001) from 1973 to 2005. The age-specific mortality rate for CVD increased with age in all three periods, especially for citizens older than 60 years. There were age stages in each period in which the mortality increase rate was the fastest (10-14 and 15-19 years old in 1973-1975; 10-14, 15-19 and over 80 years old in 1990-1992; 15-19 and over 80 years old in 2004-2005). Exponential regression function (y = b0e(b1x)) can be used for the proper description of age-specific mortality change. The ratio of YPLL for CVD in all death causes showed increase trend (chi2 = 275,630.407, P < 0.001). YPLL rate (YPLLs per 1000) in 1973-1975 was higher than those in 1990-1992 and 2004-2005. YPLL rate was positively correlated with mortality in all periods.
CONCLUSIONSThe mortality for CVD increased with time and aging. People older than 60 years were threatened by CVD mostly. Mortality trend analysis also found higher CVD deaths in people age 15-19 in Hunan residents.
Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cardiovascular Diseases ; epidemiology ; mortality ; Cause of Death ; Cerebrovascular Disorders ; epidemiology ; mortality ; Child ; Child, Preschool ; China ; epidemiology ; Humans ; Infant ; Life Tables ; Middle Aged ; Survival Rate ; trends ; Time Factors
7.Wuzhi Tablet protects against APAP-induced liver injury at different pretreated intervals in mice
Le-qian XU ; Yan-ying ZHOU ; Yi-ming JIANG ; Yun-hui XING ; Min HUANG ; Hui-chang BI
Acta Pharmaceutica Sinica 2021;56(4):1147-1154
Acetaminophen (APAP, also known as paracetamol)-induced liver injury is the leading cause of drug-induced liver injury in the world. Wuzhi Tablet (WZ, an ethanol extract of
8.Development and application of 2006 WHO Child Growth Standards.
Wei-wei FENG ; Xiao-na HUANG ; Li-min GONG ; Hui-shan WANG
Chinese Journal of Pediatrics 2013;51(9):704-707
Anthropometry
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Body Height
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Body Weight
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Breast Feeding
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Child
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Child Development
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China
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Female
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Growth Charts
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Humans
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Infant
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Infant, Newborn
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Male
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Public Health
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standards
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Reference Values
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Sex Factors
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World Health Organization
9.Structural comparison of the granted projects at Chinese Center for Desease Control and Prevention with its scientific develonment plan during the 11th 5-year period
Min WANG ; Liang CHEN ; Hui HUANG ; Jichun WANG ; Chao CHEN ; Ying ZHANG ; Xiaoping DONG
Chinese Journal of Medical Science Research Management 2012;25(1):33-36
From 2006 to 2010,381 national or provincial projects were granted to Chinese Center for Disease Control and Prevention (Chinese CDC).According to the development plan of key dsciplines made by Chinese CDC, this study stratified the granted projects and analyzed their distribution in the four units (including 37 subunits),namely,infection disease,health,chronic disease and general technology platform. The results indicated that most of the important topics proposed by our center received financial support from the government,and the supported projects were mostly in the field of infectious disease and health.The results also revealed that the key projects proposed by Chinese CDC meet the practical requirements of disease control,and those projects covered the key scientific topics and key technologies.Meanwhile,the result reflected that Chinese CDC is very competitive as far as scientific research is concerned,but the research structure is not balanced among the 4 units.
10.Evaluation of thiopurine methyltransferase genotyping and enzyme activity detection in treatment of patients with inflammatory bowel disease
Fangbin ZHANG ; Liang DING ; Xiang GAO ; Hui LIU ; Yinglian XIAO ; Minhu CHEN ; Min HUANG ; Pinjin HU
Chinese Journal of Digestion 2010;30(7):436-440
Objective To assess the predictive value of thiopurine methyltransferase genotyping and enzyme activity in relation to side effects in patients with inflammatory bowel disease (IBD) who were treated with azathioprine (AZA). Methods One hundred and eleven IBD patients (26 with ulcerative colitis and 86 with Cronh's disease) with indication of AZA administration between April 2004 and Dec. 2009 were enrolled. All patients received 2 mg/kg of AZA daily. Polymerase chain reaction and high performance liquid chromatography were used to genotype the TPMT * 2, * 3A, * 3B, * 3C and to detect TPMT activity, respectively. The association of TPMT genotype and activity with side effects was analyzed in patients treated with AZA for 24 weeks or more, or in those discontinued AZA because of adverse effects. Results Adverse effects were reported in 38(33. 9%) patients, the most frequent being myelosuppression (20. 5%). The frequency of TPMT * 3C heterozygous mutation was 0. 9% (1/112). The TPMT activity was (12. 9±4. 8) U/ml RBC with unimodal distribution. One patient with TPMT * 3C heterozygous mutation developed myelosuppression at the 4th week after AZA treatment. The TPMP genotype myelosuppression patients. Conclusions TPMT genotype mutation and low enzyme activity can be used to predict myelosuppression with high specifically and low sensitivity. In patients treated with AZA, co-administration of 5-ASA results in a high frequency of myelosuppression with no effect on TPMT activity.