1.Analysis of Calcium Channel Blockers Used in Our Hospital During the Period 1999~2001
Zhu LIANG ; Hui HE ; Qiong LUO
China Pharmacy 2001;0(12):-
OBJECTIVE:To investigate the current situation and trend of clinical application of calcium channel blockers METHODS:The kinds and sum of money of calcium channel blockers,consumed in our hospital during the period 1999~2001,were collected and the prospects of clinical application of the drugs were analyzed with consulting the relevant literature RESULTS:The consumption of calcium channel blockers remained stable during the period 1999~2001,and the most commonly-used drugs were dihydrocollidines Domestic and joint ventrue products held a leading post in clinical application CONCLUSION:Sustained and controlled release preparations of calcium channel blockers have broad prospects in clinical application
2.Management of Borrowed Surgical Instruments
Hong LI ; Hui CHEN ; Aimin ZHAO ; Guoying ZHANG ; Liang HE
Chinese Journal of Nosocomiology 2006;0(07):-
OBJECTIVE To manage the surgical instruments borrowed from medical equipment companies effectively in order to prevent or decrease the incidence of hospital infection.METHODS We analyzed the hidden trouble inducing the hospital infection by data investigation.Effective management of surgical instruments was suggested.RESULTS The management method was accepted by most departments and the surgical site infection was well controlled.CONCLUSIONS Effective management of borrowed surgical instruments should be further emphasized to ensure the safety for operation.
3.Antitumor activities and its immunologic functions of Laurencia terpenoids
Hui LIANG ; Juan HE ; Shicui ZHANG ; Chunjing DONG ; Aigu MA
Chinese Journal of Marine Drugs 1994;0(01):-
Objective To investigate the antitumor and immunologic activities of Laurencia extract(LET) in Sarcoma 180(S 180).Methods The content of total terpenoids in LET was detected by RP-HPLC and its toxicity(LD 50) was estimated by Horn assay. Tumor inhibition rates, index of thymus and spleen, proliferation of spleen lymph cells, IgA,IgG,IgM were detected. The data were analyzed by SPSS software. Results The content of total terpenoids in LET was proved to be 63.29%. LET showed low toxicity with its LD 50 more than 3160mg?kg -1. Tumor inhibition rates of test groups were significantly higher than those of the control group. LET could obviously increase the levels of index of thymus and spleen. LET increase the multiplication of spleen lymph cell.Concentrations of IgA、IgG and IgM in plasma of the test groups were higher than those of the control group. Conclusion LET rich in terpenoids is safety to be taken orally. The alga extract showed obvious antitumor activities and immunologic functions.
4.Effect of aplysin on the proliferation and apoptosis in human gastric cancer cell SGC-7901
Ying LIU ; Hui LIANG ; Ai SU ; Juan HE ; Hong YU
Chinese Pharmacological Bulletin 2010;26(3):333-337
Aim To investigate the effects of Aplysin on the inhibition of gastric cancer cell in vitro .Methods MTT assay was used to examine the inhibition of gastric cancer cell 1ine SGC-7901 by Aplysin in different concentrations and at different times.The morphologic changes and the apoptosis of SGC-7901 was observed by inverted microscope and Hematoxylin-Eosin(HE)staining.Reverse transcriptase polymerase chain reaction(RT-PCR)assay was used to detect the changes of COX-2 mRNA expressions.Results Aplysin could decrease the proliferation significantly in a dose-dependent manner in SGC-7901 cells.When treating SGC-7901 with Aplysin in concentration of 120, 240 mg·L~(-1) for 24 h, the growth of the cell was obviously inhibited observing by inverted microscope.Aiso, when treating with the same concentration for 18 h, its chromatin became crimpled and breakdown, as well as cell shrinkage and apoptotic bodies formation when using HE staining.The apoptotic rates(%)of SGC-7901 was(15.0±2.12)%, (18.4±2.3)%, respectively, which was significantly higher than(1.4±0.55)% that in control group(P <0.01).60、120、240 mg·L~(-1) Aplysin could not effectively inhibited the mRNA expressions of COX-2(P >0.05).Conclusions Aplysin can inhibit the proliferation and induces apoptosis of SGC-7901 cells.
6.Establishment and practice of the evaluation system on research ability of staff of the maternal-child health
Hui LIAO ; Jingrui YU ; Ping QIAN ; Jiayi HE ; Jiazhi LIANG
Chinese Journal of Medical Science Research Management 2013;26(6):421-423,432
Scientific research is important for the improvement of the health-care techniques,and is certainly important for the health of women and children of the whole society.With the development of medical science,research ability of maternal and child healthcare professionals is deemed essential.And the evaluation of their research ability,stimulation,and creativity have been important topics to address.Here we introduce an evaluation system for research capacity of maternal and child healthcare professionals established in our hospital,which is the fruit of constant exploration and practice for several years.It is proved to be practical,simple and feasible.The establishment methods,practices and experiences of the evaluation system are presented in this paper.
7.THE ANTICANCER ACTIVITIES AND MECHANISM OF LAURENCIA TERPENOIDS EXTRACT
Hui LIANG ; Juan HE ; Chunjing DONG ; Aiguo MA
Acta Nutrimenta Sinica 2004;0(06):-
Objective:To investigate the effect of Laurencia terpenoid extract (LET) on tumor inhibition,immune modulation and apoptosis of Sarcoma 180 cell. Method:The LD50 of LET was estimated by Horn assay. The models of S180-bearing mice were established and divided into 4 groups which were given LET 0 (control group), 25 (low-dose group), 50 (mid-dose group), 100 (high-dose group) mg/kg bw respectively for 10 d. Tumor inhibition rates were detected in treatment groups and control group respectively. To weigh exactly the thymus and spleen to calculate their indices. The proliferation effect of LET on spleen lymphocyte was evaluated by MTT assay. The apoptosis of tumor cell was assayed by flow cytometry. Results:The LD50 was more than 3 160 mg/kg bw. LET had low toxicity. The average tumor weights of the supplemented groups were all less than the control group(P
8.Laparoscopic liver resection allows quicker recovery of liver function after hepatectomy for hepatocellular carcinoma
Hui HOU ; Dachen ZHOU ; Xiao CUI ; Chunli WU ; Lei WANG ; Shubo PAN ; Liang HE ; Xiaoping GENG
Chinese Journal of General Surgery 2017;32(8):698-701
Objective To compare the perioperative outcomes of laparoscopic liver resection (LLR) versus open liver resection (OLR) for hepatocellular carcinoma (HCC).Methods A total of 89 HCC patients undergoing liver resection between January 2012 and November 2016 were enrolled.Nonparametric tests were employed to compare the clinicalpathological characters and preoperative outcomes.Results No significant difference was observed in clinicalpathological features and postoperative morbidity.LLR group had shorter hospital stay (Z =4.642,P <0.01),lower serum ALT level in 1st,3rd and 5 day (Z =2.157,3.089,2.384,all P <0.05) and AST level in 1st-and 3rd-day postoperatively (Z =2.688,2.566,all P <0.05).The growth rate in serum total protein (TP) and albumin (ALB) postoperatively is higher for LLR group (y =2.348 4x + 51.696 vs.y =0.902 9 + 35.532),(y =1.539 9x + 29.68 vs.y =0.732 9x + 30.406).Conclusion LLR allows quicker liver function recovery and shortens patients' postoperative hospital stay.
9.Three-dimensional individual digital anatomy for microsurgery of cerebellopontine angle region tumor
Wensheng LI ; Hui WANG ; Haiyong HE ; Chaofeng LIANG ; Chuan CHEN ; Ying GUO
Chinese Journal of Microsurgery 2012;35(3):201-203,后插9
Objective To summary the microsurgery clinical experience of 21 patients with cerebellopontine angle tumor by the help of three dimensional individual digital anatomy. And to evaluate the value of three dimensional individual anatomy in the treatment of tumors in cerebellopontine angle. Methods Between January 2011 and November 2011,21 patients with various cerebellopontine angle tumor,managed at the Third Affiliated Hospital of Sun Yat-Sen University, underwent CTA scan, and reconstruct the local anatomy by 3D view software. According to the individual anatomical model, the microsurgery program by restrosig moid approach was developed. Results All patients had reposition of the bone flap at original site after craniectomy during the same operative setting mentioned above with retrosigmoid approach. No complication was noted.Patients did not have any delayed postcraniectomy pain at operation site.Postoperative computed tomography of the skull showed good healing and shaping of the suboccipital bone at the surgical region. Conclusion With the help of three dimensional individual anatomy, the microsurgery of cerebellopontine angle tumor underwent less postoperative complications.This study provides a safe and effective individualized microsurgical methods by restrosig moid approach.
10.Microsurgical treatment of tumors in cervical spinal canal
Hui WANG ; Dejin SHI ; Wensheng LI ; Chaofeng LIANG ; Haiyong HE ; Feng QIN ; Zhuopeng YE ; Ying GUO
Chinese Journal of Microsurgery 2008;31(6):417-419
Objective To report effects of microsurgical treatment for tumors in cervical spinal canal. Methods A total of 32 cases of tumors in cervical spinal canal had received microneurosurgery through a posternmedial approach. 22 cases had received reconstruction of cervical spinal canal stability. Results A total tumor resection was performed in 26 cases (81.25%),a subtotal tumor resection was conducted in 6 cases(18.75%). A cemplete recovery was achieved in 23 cases(71.88%), an improvement of symptoms was achieved in 6 cases(18.75%), and no improvement in 3 cases(9.38%), no death was encountered. Follow up observations were carded out in 30 cases for 3 months to 3 years. MRI examinatious 3 months after operation in 26 cases found no residual or recurrent tumor,recurrence was seen in 3cases of astrocytoma, 1 case was invariable. X-ray radiography in 26 cases showed good vertebral stability ,spinal deformation was found in 4 eases. Conclusion Microsurgery in early period play a key role in treatment of cervical spinal tumors. Reconstruction of spinal canal stability is important to patients.