Polymeric micelles as effective drug carriers have been paid wide attention. They have many considerable advantages in cancer therapy, such as high efficiency, long acting and high drug loading etc. The paper reviewed the type, preparation materials and drug lording methods of polymeric micelles, especially discussed the targeting strategy of tumor-targeting drug delivery systems and the ap-plication examples of polymeric micelles in targeting drug delivery systems.

Airway remodeling is one of the main pathological changes of bronchial asthma. It has shown that a variety of cytokines, including chemokines, growth factors, matrix proteins, participate in and even strengthen airway remodeling through building complex signal transduction pathways. Many traditional Chinese medicines,such as shegan mahuang decoction,have a regulatory role in airway remodeling.

ObjectiveTo evaluate the clinical efficacy of acupuncture plus moxibustion in treating chronic superficial gastritis (due to colddeficiency of spleen and stomach).MethodTotally 112 patients with chronic superficial gastritis (due to cold deficiency of spleen and stomach) were randomized into a treatment group of 56 cases and a control group of 56 cases. The treatment group was intervened by acupuncture plus moxibustion, while the control group was by using Ranitidine, both for 2 treatment courses (20 d).ResultAfter 2 treatment courses, the total effective rate of the treatment group was significantly higher than that of the control group (P<0.01); in comparing the gastroscopic results after treatment, the total effective rate of the treatment group was significantly superior to that of the control group (P<0.01).ConclusionAcupuncture plus moxibustion can produce a significantly higher therapeutic efficacy than orally taking Ranitidine in treating chronic superficial gastritis.

Metrology as a main real-time detection method for equipment performance,plays an important role in improving the medical treatment and realizing the modernization of medical science.What's more,suggestions are given on how to site the international standards as example to improve the hospital quality management system and metrological approval system;to normalize and promote hospital foundational management and the development of metrological technology;to realize unified,accurate metrology;and to enhance medical quality and social benefit,which catering the requirement of hospital metrological management and sustainable development.[Chinese Medical Equipment Journal,2008,29(2):105-106]

Radiation retinopathy is a kind of retinopathy after expose to radiation sources or radiotherapy.In China,it occurs mostly after radiotherapy for nasopharyngeal carcinoma.With the development of radiation equipment and radiotherapy technique,the target of treatment is improved and side effects decreased.However,better curative effect may bring longer surviving time and higher incidence of radiation retinopathy eventually.Radiation retinopathy is easily ignored or misdiagnosed as its fundus change is similar to that of some common retinal vascular diseases.Besides,there is no unified and standard treatment for radiation retinopathy.Thus,radiation retinopathy usually leads to incurable vision loss.Oculist and oncologist should pay close attention to this disease.This review focuses on the pathogenesis,clinical manifestation,assistant examination,diagnosis,differential diagnosis and therapeutic method for radiation retinopathy,especially the latest treatment advances in order to achieve early diagnosis and timely treatment.

The autonomy is one of the basic authorities of patients.It isn't only an ethical concept,but also can help enhance the efficacy and compliance to a certain extent.The autonomic behavior of the patients isn't as optimistic as we think.The patient's autonomy can be influenced by many factors.We should base on the principles,advantage,respect and communication,to encourage patients to make an appropriate and unbiased decision and change into a collaborative,patient-centered doctor-patient relationship model.

In addilion to angiotensin II, angiotensin-(1-7) is another importarrt regulatory peplide of the renin-angiotensin system. It manly birds with a spediic receptor known as Mas, showing a vascijlar dilaSion and an ansi-proliferaSion effect, which counterbalances the effects of angiotersin H, mcluding VasoconstiiicSion, blood pressure mcrease, proliferaSion, \M\ne reteniion, etc. Recerrt studies demonstrate that angiotensin-(1-7) and its Mas receptor play aciiVe roles n local phyiiological process and showan protertive effect n many pathological condiSions.

Choroidal neovascularization (CNV) ithe leading cause of vision disordecaused by variouretinal diseases.Apresent,many therapeutimethodare employed clinically,such aphotodynamitherapy (PDT),anti-vasculaendothelial growth facto(anti-VEGF) and transpupillary thermotherapy (TTT).However,none of them can cure CNV thoroughly and repeated treatmenirequired usually.The reason forecurrenCNV istill unclear.Choroidal hypoperfusion associated with Pdmay be one of the reasons.The purpose of thireview ito discusthe problem of choroidal hypoperfusion associated with PDfoCNV awell aitimpacon the eye and possible solutions.Thipapepresentevidenceof choroidal hypoperfusion aftePDand itrelationship with clinical outcomes.Meanwhile,the effecof combination therapy iassessed.Finally,low-fluence Pdirecommended apotential method to reduce choroidal hypoperfusion.

Acrylamide ; analysis ; Air Pollutants, Occupational ; analysis ; Chromatography, High Pressure Liquid ; methods ; Workplace

Aptitude ; Humans ; Integrative Medicine ; manpower