OBJECTIVETo evaluate the association between leptin receptor gene polymorphisms and hypertension in Chinese population.

METHODSThe keywords "Hypertension", "Blood Pressure, high", "Leptin Receptor", "OB Receptor", "LEPR Protein", "CD295 Antigens", and "LEPR" were used to search the literature to identify the relevant studies for meta-analysis using software RevMan 5.0 and Stata 11.0 software.

RESULTSThirteen studies involving 3210 cases of hypertension and 1881 controls were included in the meta-analysis. Overall, a significant association was found between Gln223Arg gene polymorphism and hypertension in allele contrast and dominant genetic model (for allele contrast genetic model: OR=1.17, 95%CI=1.48-2.15, P<0.0001; for dominant model: OR=2.18, 95%CI=1.75-2.72, P<0.00001). No statistically significant correlation was found between Lys109Arg polymorphism and hypertension (for allele model: OR=1.13, 95%CI=0.84-1.51, P=0.42; for recessive genetic model: OR=0.88, 95%CI=0.33-2.32, P=0.79; for dominant genetic model: OR=1.20, 95%CI=0.85-1.71, P=0.29; for additive genetic model: OR=0.90, 95%CI=0.34-2.42, P=0.84).

CONCLUSIONThere is no significant correlation between Lys109Arg variant of LEPR gene and hypertension in Chinese population, but the Gln223Arg polymorphism is associated with hypertension in allele contrast and dominant genetic model. Chinese population with an A allele are at a high risk of developing hypertension.

Alleles ; Asian Continental Ancestry Group ; genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Hypertension ; epidemiology ; genetics ; Polymorphism, Single Nucleotide ; Receptors, Leptin ; genetics