Objective To understand the quality of life of elders in the community of Shangqiu and analyze the affecting factors to provide a scientific evidence which could improve their quality of life.Methods The general questionnaire and World Health Organization Quality of Life Brief Evaluation From were used among 116 elders in two communities of Shangqiu.Results The quality of life of elders was in low level.The mainly factors that influencing the quality of life of elders in the community of Zhengzhou were age,education status,economic income,hobbies and interest,family relation,physical exercise.Conclusions The factors that influence the elders in community are various.To improve quality of life of elders,community workers should take relevant measures and encourage family members to participate in caring elders.

Objective To develop a RP-HPLC method to determine adenosine in Chongcaoqizhi granule. Method The separation was performed in a Kromasil ODS-1 column (250 mm?4.6 mm, 5 ?m) with a mobile phase of phosphate buffer solution (pH 6.5) - methanol (85∶15). The flow was 0.7 mL/min and the detective wavelength was set at 260 nm. Results The standard adenosine showed a good linear correlation at range of 1.016~12.192 ?g/mL. The linear regression equation and correlation coefficient (r) were Y =169339X -82318, r =0.9990, respectively. The average recovery of the loading was 98.02% and the RSD was 1.72%. The average content of adenosine was 12.45 ?g/g. Conclusion This method is accurate, reproducible and highly selective, and can be used for quality control of Chongcaoqizhi granule.

Blood Coagulation Factor Inhibitors ; antagonists & inhibitors ; blood ; Factor VIII ; administration & dosage ; antagonists & inhibitors ; immunology ; Hemophilia A ; drug therapy ; genetics ; immunology ; Humans ; Immune Tolerance ; Isoantibodies ; blood ; immunology ; Recombinant Proteins ; adverse effects ; immunology ; therapeutic use ; Risk Factors ; Time Factors

Biomarkers ; Environmental Monitoring ; Humans

Objective To observe and explore the effect of aripiprazole(Ari)and olanzapine(Ola)on body weight and lipid metabolism in schizophrenia(SP)patients.Methods 96 patients with SP were randomly divided into two groups,48 cases in the observation group and the control group.The control group was treated with Ola,while the observation group was treated with Ari.Before and 6 weeks after treatment,the height,body weight,blood glucose (FBG),insulin(INS),low -density lipoprotein(LDL),triglycerides(TG),total cholesterol(TC)levels in the two groups were detected,insulin resistance index(IRI)and BMI were calculated.Results The differences of body weight,BMI,FBG,INS,IRI,LDL,TG,TC before treatment between the two groups were not statistically significant (t =0.161,0.564,0.277,0.078,0.092,0.124,0.421,0.245,all P >0.05).After 6 weeks treatment,FBG,INS, IRI in the observation group were (4.71 ±0.58)mmol/L,(21.85 ±12.36)μU /mL and (4.62 ±2.14),the differ-ences were not statistically significant compared with before treatment(t =0.800,0.571,0.276,all P >0.05).Those in the control group were (5.14 ±0.56)mmol/L,(28.54 ±11.25)μU /mL and (6.23 ±3.82),which were signifi-cantly higher than those before treatment(t =4.898,3.361,2.628,all P <0.05),and were also significantly higher than those in the observation group(t =3.695,2.773,2.547,all P <0.05 ).After 6 weeks treatment,the body weight,BMI,LDL,TG,TC in the observation group were not statistically significant compared with before treatment (t =0.262,0.638,0.124,0.421,0.245,all P >0.05 ),those in the control group were significantly higher than before treatment(t =2.601,3.834,5.773,5.838,4.375,all P <0.05),and were also significantly higher than those in the observation group(t =3.052,3.265,5.264,5.496,4.188,all P <0.05).Conclusion Ari treatment for SP has no significant effect on glucose and lipid metabolism and body weight in patients,and the effect of Ola treatment on patients'body weight and lipid metabolism is more significant.

Objective To observe the influence of mental rehabilitation combined with family intervention on self -efficacy and quality of life of patients with schizophrenia.Methods 92 cases of schizophrenia patients were choosed to be the research object.They were divided into control group (46 cases)and observation group (46 cases) according to random number table method.The control group was given mental rehabilitation while the observation group was given the mental rehabilitation combined with family intervention treatment.The clinical efficacy of the two groups of patients was observed after six months.The patient's self -efficacy was assessed by using self -efficacy scale (GSES),and the patient's quality of life was assessed by using the quality of life scale (QLQ).Results Six months after treatment,the score of PANSS in patients with positive symptoms[(14.19 ±4.16)points],negative symptoms [(16.29 ±4.92)points],mental symptoms[(35.56 ±6.75)points]and total score[(65.84 ±15.83)points]in the observation group were lower,which were better than those of the control group[(17.37 ±5.27)points,(21.11 ± 5.64)points,(42.37 ±7.92)points and (80.85 ±18.83)points],and the differences were statistically significant(t =3.212,4.368,4.438,4.544,all P <0.05).The total effective rate was 86.96% in the observation group,which was significantly higher than 67.39% in the control group,the difference was statistically significant(χ2 =4.998,P =0.025).The self -efficacy scores of the two groups were higher than before the treatment,which of the observation group[(3.51 ±0.62)points]was better than that of control group[(2.13 ±0.48)points],the difference had statistical significance(t =5.593,P =0.000).After treatment,the patient's quality of life score such as emotional function [(59.82 ±11.38)points],cognitive function[(69.43 ±12.32)points],role function[(69.77 ±12.31 )points], physical function[(75.38 ±14.01 )points],social function[(66.28 ±13.03)points]and so on were higher than before treatment[(56.88 ±10.36)points,(42.01 ±9.29)points,(47.02 ±9.17)points,(60.34 ±10.89)points, (53.92 ±10.76)points].Results of the observation group were better than those of the control group[(53.07 ± 10.13)points,(63.02 ±11.17)points,(62.03 ±11.17)points,(67.33 ±11.74)points,(60.87 ±12.62)points], the differences had statistical significance(t =3.005,2.664,3.158,2.987,2.023,all P <0.05).Conclusion Therapy of mental rehabilitation combined with family intervention can improve the clinical curative effect of schizophrenia patients, and improve the patient's self -efficacy and quality of life.It is worthy of clinical popularization and application.

External evaluation of large medical institutions is key to performance management in the medical sector,which is both a major means for the government to manage such institutions and a key guideline for their internal performance management. Based on a study on the pathways of such institutions in the UK,the USA and Japan in their external evaluation of performance,the paper summarized practices of Shanghai,Shenzhen,Zhenjiang and Beijing,in an attempt to offer references for building the external evaluation system for such institutions in China.

Objective To evaluate the effects of small dose of dopamine on the renal blood flow in the elderly patients undergoing cardiac valve replacement under cardiopulmonary bypass (CPB).Methods Sixty elderly patients,of ASA physical status Ⅱ or Ⅲ,aged 65-74 yr,weighing 52-77 kg,scheduled for elective cardiac valve replacement under CPB,were randomized to receive either normal saline (group C,n =30) or dopamine (group D,n =30).After beginning of surgery,CPB was established routinely.In group D,dopamine was continuously infused for 20 min at a rate of 2 μg· kg-1 · min-1 starting from 10 min after the hearts were perfused with cardioplegic solution for the first time,while the equal volume of normal saline was given in group C.The left renal blood flow velocity was measured by transesophageal echocardiography and mean arterial pressure was recorded before and after dopamine infusion.Blood samples were obtained before surgery and at 24 h after surgery for determination of blood urea nitrogen concentrations.Results Blood urea nitrogen concentrations were significantly increased at 24 h after surgery than that before surgery in the two groups.There was no significant difference in mean arterial pressure and the left renal blood flow velocity before and after dopamine infusion between the two groups.Conclusion Small dose of dopamine (2 μg· kg-1· min-1) dose not increase the renal blood flow or improve the postoperative renal function in the elderly patients undergoing cardiac valve replacement under CPB.

OBJECTIVETo observe the intervention of Dachengqi Granule (DG) on the apoptosis of small intestine smooth muscle cells (SMCs) in rats with multiple organ dysfunction syndrome (MODS) and its mechanisms.

METHODSHealthy 100 adult Wistar rats were randomly divided into the control group (n =20), the MODS model group (n =40), and the DG group (n =40).E. coli suspension was peritoneally injected to rats in the model group and the DG group to establish bacterial peritonitis induced MODS model. DG at 1 mL/100 g was administered by gastrogavage to rats of the DG group, twice daily for 3 successive days. Twenty-four hours after modeling, the proximal segment of intestine was taken and stained by using terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) and immunohistochemistry. Changes of apoptosis quantity of SMCs and the expression of Bcl-2 associated X protein (Bax), B cell lymphoma/leukemia-2 (Bcl-2) and cytochrome c protein (Cyt c) in mitochondrial apoptotic signaling pathway were observed.

RESULTSCompared with the control group, the apoptosis quantity of SMCs and the expression of Bax and Cyt c protein significantly increased, and the expression of Bcl-2 protein significantly decreased in the MODS model group (P <0.01). Compared with the MODS model group, the apoptosis quantity of SMCs and the expression of Bax and Cyt c proteins significantly decreased, and the expression of Bcl-2 protein significantly increased in the DG group (allP <0.01).

CONCLUSIONDG could inhibit apoptosis of SMCs through suppressing activation of mitochondrial apoptotic signaling pathway in intestinal SMCs, thus promoting the recovery of the gastrointestinal motility function in rats with MODS.

Animals ; Apoptosis ; drug effects ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; In Situ Nick-End Labeling ; Intestine, Small ; physiopathology ; Multiple Organ Failure ; drug therapy ; Muscle, Smooth ; physiopathology ; Myocytes, Smooth Muscle ; drug effects ; Plant Extracts ; pharmacology ; therapeutic use ; Proto-Oncogene Proteins c-bcl-2 ; Rats ; Rats, Wistar ; bcl-2-Associated X Protein ; metabolism