OBJECTIVE:To probe into the standardized administration in the public bid for drug purchase of medical institutions.METHODS:Experiences and understandings in carrying out ISO9001standards in the public bid for drug purchase of our hospital were introduced;problems involved in which were analyzed and some advices were put forward.RESULTS&CONCLUSION:The practice of ISO9001standards does good to the consummation and standardization of the public bid of drug purchase in Chinese medical institutions.

OBJECTIVE:To study the general layout on the quality control of clinical pharmacy work of Xuzhou city during the period of2005～2008.METHODS:The problems appeared in hospital clinical pharmacy were analyzed by adopting ISO9001process control theory,i.e.PDAC cyclical quality management method,and suggestions on the corresponding scheme and practices were raised.RESULTS&CONCLUSIONS:Studying the general layout on the quality control of clinical pharmacy work by means of ISO9001process control theory is conducive to the development of clinical pharmacy of Xuzhou city.

Burns ; complications ; metabolism ; Endotoxemia ; etiology ; metabolism ; Humans ; Multiple Organ Failure ; etiology ; metabolism ; Myocytes, Cardiac ; metabolism

Blood Glucose ; analysis ; Diabetes Complications ; prevention & control ; Diabetes Mellitus, Type 2 ; blood ; therapy ; Humans ; Risk Factors

Objective: To carry out a preliminary study on serum parmacochemistry of Dahuang Fuzi Decoction (DFD) and to research the pharmacodynamic material basis through analyzing the constituents absorbed into blood. Methods: HPLC fingerprints of DFD and serum of rats after DFD treatment were established with serum pharmacochemistry method. The serum samples collected after DFD and single crude drug treatments were compared, the constituents absorbed into the serum after DFD ig administration was determined. Results: After the rats were ig administered with DFD, 18 transitional constituents to blood were detected, among which 14 were metabolites and 4 were prototype constituents. Conclusion: After DFD treatment, the constituents absorbed into blood are mainly from Rhei Radix et Rhizoma and Aconiti Lateralis Radix Praeparata, and the serum pharmacochemistry signs could provide the evidence for the further research of the material basis of the decoction.

Objective:To investigate the consistency of two methods in the measurement of bone mineral density in the lateral lumbar vertebra.Methods:The bone mineral densities of the 2nd,3rd and 4th lumbar vertebras in 18 female patients,at a preset side lying position,were measured respectively by two methods(lateral spine analysis,LS and lateral vertebral analysis,LVA) provided by the dual-energy(X-ray) absorptiometry(GE Lunar,Prodigy).The results were recorded and analyzed by SPSS(Version(10.0).) The values of bone mineral density were displayed by boxplot,paired and analyzed by(Wilcoxon's) signed rank test and(Pearson's) correlation analysis.Statistical significance was considered when P(0.05),) and were clearly correlated(P

To prepare and study the pharmacokinetics and release bioavailability in olunteers and concentrations in plasma in patients. METHODS: Ethylcellulose was used matrix in phase separation-coacervation for preparation of microencapsulation. The release experiments were performed in a rotating shaker. The isoniazid concentration in plasma was determined by spectrophotometrical method following a single oral dose of sustained-release cupsule and ordinary tablet respectively given to 10 volunteers in a open randomized cross-over test. MCP86 was used to process main pharmacokinetic parameters. RESULTS: The sustained-release of capsule and ordinary teblet in vitro, T50 was 1 h and 0.032 h respectively. The drug in sustained-release capsule was sustained release over 10 h. The main parameters in body: ordinary tablets: cmax=11.12 μgml-1, tmax=1.41 h, K=0.201 h-1; sustained release capsule: cmax=4.99 μgml-1, tmax=1.80 h, K=0.03 h-1. The concentration of blood at 36 h was (0±0)μgml-1 and 1.63 μgml-1 respectively. Except tmax, there was significant difference between the two fomulations (P＜0.01). The concentration of blood in patient at 1.5 h and 36 h. ordinary tablet and sustained-release capsule respectively were (8.24±2.60)μgml-1, (0±0)μgml-1and (3.69±0.86)μgml-1, (2.09±0.56)μgml-1. CONCLUSION: The sustained-release capsule will play an important part in prevention and treatment of tuberculosis as the result of its reasonable formulation and simple technology.

Analysis of metabolic activities of cytochrome P450 isoenzyme is a crucial index to study drug/toxicant metabolism, drug-drug interaction, polymorphism and et al. Due to this practice, it is important to use the proper probe substrate and to conduct the experiment under optimal conditions. The validation information in literatures on the most common and newest in vitro probe substrates have been reviewed.

Objective] To study the Xin'an doctor Sun Yikui Sun Wenyuan basis four diarrhea cases, in order to reveal Sun Yikui diarrhea syndrome differentiation syndromes characteristics. [Method] With Sun Wenyuan basis of diarrhea four proven cases as example, the combination of Neijing, Treatise on Febrile Disease, the Synopsis, Mingmen theory, Danxi academic ideas and related works and academic thoughts of Sun's, interpretation of Sun's diarrhea cases, comprehensive analysis of the syndrome differentiation syndromes characteristics. [Results] From the Sun Wenyuan basis diarrhea in four cases to know Sun Yikui grasp of vital theories and Danxi academic thoughts, clinical cure, the doer phlegmy wet, dyspepsia, the accountability of virtual are of pixu(deficient spleen), kidney deficiency, with particular emphasis on the pathological factors of kidney Yang deficiency, the author was good at using insurance and pills, Erchen Decoction, Benefit-stomach Shengyang Moisture-penetration soup, Liujunzi Decoction and revised prescriptions. [Conclusion] Sun Wenyuan basis contained diarrhea basis, Sun's clinically curing diarrhea with outstanding characteristics, the curative effect is distinct, we should combine classical and Sun's works to conduct the thorough research to the related basis, broaden the clinical cure drainage, help to improve the ability of clinical treating diarrhea.

OBJECTIVE:To study the isolation of lentinan,the average molecular weight of which ranged within400000to600000.METHODS:The fine lentinan was purified by2—diethyllaminoethyl—cellulose anion exchange column chro-matography,which was then isolated by dextran gel G-200column chromatography with the molecular weights determined by high performance gel chromatography.RESULTS:The average molecule weight of the isolated lentinan ranged from400000to600000.CONCLUSION:This method can be used for the isolation of lentinan.