Objective To analyze the pathogens and antibiotic resistance profile in patients with urinary tract infections who were treated from 2011 to 2013 to provide evidence for rational use of antimicrobial agents.Methods SIEMENS MicroScan WalkAway 96 Plus system or API system was used for identification of bacteria and fungi.Antimicrobial susceptibility testing was conducted by disk diffusion method.WHONET 5.6 software was used for data analysis.Results A total of 344 (29.9%) strains of pathogens were detected from 1 151 midstream urine culture specimens,of which 76.5% (263/344)were gram negative bacteria,including E.coli (53.2%,183/344),K.pneumoniae (9.6%,33/344),Proteus (6.1%,21/344),and P . aeruginosa (3.5%,12/344).About 23.5% (81/344)of the isolates were gram-positive bacteria,including Enterococcus faecalis (4.9%,17/344)and coagulase-negative Staphylococcus (4.4%,15/344).ESBLs were produced in 51.9% of the E. coli isolates and 63.6% of the K.pneumoniae isolates.ESBLs-producing strains showed significantly higher resistance rates to cephalosporins,quinolones,tetracyclines,sulfonamides and other antimicrobial agents than non-ESBLs-producing strains (P <0.05).Enterobacteriaceae isolates were highly sensitive to carbapenems (90.5%-100% sensitive).P .aeruginosa strains were relatively sensitive to ciprofloxacin,amikacin and meropenem (83.3%).Gram-positive cocci remained highly sensitive to antimicrobial agents.Regular monitoring and timely analysis of the pathogens of urinary tract infections and their resistance profile are of great importance to rational use of antimicrobial agents.

The theory of 'restraint subsequent to disorders caused by unrestrained excess' is the essence of the doctrine on yunqi(five successive evolutive phases corresponding to five elements) as well as an important part of the theory of Chinese medicine.It reveals a phenomenon about growth,transformation and restriction that commonly exists in the natural world.Interpromotion and interrestraint of the five elements,opposition and mutual basement of Yinyang,system science,natural phenomena and cultural phenomena are all governed by this theory.This article approaches the theory of 'restraint subsequent to disorders caused by unrestrained excess' from the viewpoint of nature,physiology,pathogenesis,therapeutics and practice,pointing out its significance in the development and clinical modernization of Chinese medicine.

Objective To investigate the analysis of Magnesium Sulfate labetalol in the treatment of early onset severe preeclampsia and intervention. Methods Randomly selected from 2015 to 2017 years with early onset of severe preeclampsia patients 40 cases as the object of this study, all patients were treated with labetalol and Magnesium Sulfate drug drug treatment, the treatment process of nursing the patients and the nursing results were summarized. Results The blood pressure of the patients were smoothly control, 40 patients were eclampsia, and did not appear the phenomenon of death. And 37 cases of neonatal had a higher Apgar score. Conclusion In Magnesium Sulfate labetalol on early onset severe preeclampsia were treated on the application of nursing intervention, can effectively control the blood pressure of patients, and effectively alleviate the condition.

? AIM: To evaluate efficacy of Ranibizumab and Conbercept for wet age-related macular degeneration ( wAMD) .?METHODS: This was a retrospective case series study. Thirty patients ( 30 eyes ) with wAMD were enrolled to receive intravitreal injections of ranibizumab (0.5mg) on 3 consecutive monthly schedule and 28 patients (30 eyes) with wAMD were enrolled to receive intravitreal injections of conbercept ( 0.5mg ) on 3 consecutive monthly schedule.Best corrected visual acuity ( BCVA ), optic coherence tomography ( OCT ) measurement were compared at 1mo after injections.?RESULTS: One month after every injection, the BCVA increased while the central macular thickness ( CMT ) decreased compared with those before treatment in group A and B (P<0.05).BCVA and CMT changes between two groups were no statistically different (P>0.05).?CONCLUSION:Ranibizumab and conbercept therapy can control the prognosis of wAMD and improve the vision effectively. There is no statistical difference on the curative effect between two drugs for 3mo.

Objective To application of solution focused approach in the functional gastrointestinal disorders.Methods 64 hospitalized clients with functional gastrointestinal disorders were randomly divided into the observation group and the control group with 32 cases in each group.We applied the normal nursing intervention to the control group,while applied the solution focused approach to the observation group.The anxiety and depression score,score of coping way and gastrointestinal symptoms were evaluated using t test.Results The scores of anxiety and depression,coping way and gastrointestinal symptoms were better in the observation group than those in the control group.Conclusions Adoption of solution focused approach can relieve FGID sufferers'negative emotion,such as anxiety and depression,increase sufferers' coping capacity and symptoms,which demonstrate pivotal significance for rehabilitation of functional gastrointestinal disorders.

Rheumatoid arthritis ( RA) is a kind of autoimmune disease with high morbidity characterized in synovitis.It has become a key goal for achieving an early RA remission.It is very important for application of RA remission normatively in the treatment of RA.In this paper, comparison and application of various RA remission criteria were reviewed, such as American College of Rheu-matology (ACR), European League Against Rheumatism (EULAR), US Food and Drug Administration (FDA), Outcome Measures in Rheumatoid Arthritis Clinical Trials ( OMERACT) group, ACR /EULAR remission criteria, etc.

Integrin is a main factor that mediates adhesive attraction between the cell and the extracellular matrix,and it participates in the formation of new vessel lumens and the construction of the rete vasculosum by regulating endothelial cell adhesion and migration.The extracellular matrix is the ligand of integrin.Collagen and laminin's deposition form new vessel lumens.The vascular endothelial growth factor promotes the proliferation of endothelial cells,accelerates angiogenesis and increases the permeability of blood vessels.This review focuses on the roles and correlation of integrin and VEGF in angiogenesis.

Lysophosphatidic acid(LPA) is a potent bioactive lipid that has multiple specific effects on vessel wall cells,blood cells,cardiac myocytes and cardiac fibroblasts.Activated platelets are the primary source of LPA in circulation,which in turn stimulate platelet aggregation.It has shown that LPA can promote the formation of atherosclerosis and thrombus under certain conditions that might aggravate cardiovascular diseases,especially ischemic heart disease.LPA can enhance endothelial permeability and cause barrier dysfunction in the early phase of coronary atherosclerosis,as well as in the late phase trigger platlet activation and lead to intra-arterial thrombus formation upon rupture of the atherosclerotic plaque,finally cause myocardial ischemia and infarction.Furthermore,LPA can stimulate cardiac myocyte hypertrophy and fibroblasts proliferation,which aggravate myocardial hypertrophy after infarction.So,LPA plays an important role in the development of ischemic heart disease.

Nuclear factor-?appa B(NF-?B) is an important transcription factor in the expression of any inflammatory media.The role of NF-?B in rheumatoid arthritis has been thought high recently.This review presents the role of NF-?B in rheumatoid arthritis,and the research progression of intervention therapy in inhibition of the activation of NF-?B is also introduced.

Objective:To investigate the consistency of two methods in the measurement of bone mineral density in the lateral lumbar vertebra.Methods:The bone mineral densities of the 2nd,3rd and 4th lumbar vertebras in 18 female patients,at a preset side lying position,were measured respectively by two methods(lateral spine analysis,LS and lateral vertebral analysis,LVA) provided by the dual-energy(X-ray) absorptiometry(GE Lunar,Prodigy).The results were recorded and analyzed by SPSS(Version(10.0).) The values of bone mineral density were displayed by boxplot,paired and analyzed by(Wilcoxon's) signed rank test and(Pearson's) correlation analysis.Statistical significance was considered when P(0.05),) and were clearly correlated(P