Erectile dysfunction(ED) is a common condition in men from 40 to 70 years of age,and during the last decades intensive research has highlighted clinical practice and public sectors.The development of Sildenafil,Vardenafil and Tadalafil have made the first class of agents capable of treating ED with convenient oral administration available.In the past years intracavernosal and intraurethral agents have been developed,but their clinical use was limited due to its invasiveness,and with high discontinuation rates.Gene therapy will be an effective method in future.

Objective To discuss the feasibility of application of laryngeal mask airway(LMA)in pediatric corrective surgery of lingual frenum. Methods Retrospective study was conducted of 42 chil-dren using laryngeal mask airway in selective surgical correction of lingual frenum under general anesthe-sia in our hospital. The childrenˊs vital signs were recorded at five different time points:baseline before an-esthesia(T0),consciousness and eyelid reflex disappear just after anesthesia induction(T1),time right af-ter the LMA insertion(T2),3 ~ 5 min after beginning of operation(T3),and time at the extubation(T4). The success rate of first LMA insertion and the number of changing to other ventilation way were recorded. The shift of LMA and postoperative sore throat within 24h were recorded. Results The success rate of the first LMA insertion was 85. 71% . Intraoperative laryngeal mask airway leak and shift did not occur and the ventilation was also good. Vital signs of the children were stable during operation. The incidence of postop-erative sore throat was 15% within 24h. As to the heart rate,the vital signs of baseline T0 were significant-ly different from other time points(T1,T2,T3,T4). After the anesthesia,there were no significant differ-ences in heart rate among different time points(T1,T2,T3,T4). Compare with T2 and T3,the values of partial end expiratory pressure of CO2 at T0,T1,and T4 were significantly different. Compare with T0,the values of mean arterial pressure at T1,T2 and T3 were significantly different,but there was a significant difference in mean arterial pressure between T1 and T4. As to the pulse oxygen saturation,all the values were above 95% . Conclusion Laryngeal mask airway is a supraglottic airway management method. The advantages of fewer haemodynamic changes and postoperative complication are confirmed. It is feasible and safe for securing the airway in surgical correction of lingual frenum.

Objective:To explore the effect of sodium cantharidate vitamin B6 injections in the adjuvant treatment of advanced cer-vical cancers. Methods:Totally 60 cases of advanced cervical cancer patients were randomly divided into the observation group and the control group, and the control group was given common DP chemotherapy and radiotherapy, while the observation group was given sodium cantharidate vitamin B6 injections additionally. After the 6-week treatment, the short-term curative effect, bone marrow inhibi-tion adverse reaction, immune function and life quality were compared between the two groups. Results:The short-term curative effect in the observation group was 66. 7%, which was significantly higher than that in the control group (40%)(P<0. 05). The degree of adverse reaction was significantly lower than that in the control group with statistical significance (P<0. 05). After the treatment, CD8 +, NK cells and CD8 + / CD4 + in the two groups were significantly improved, and those in the observation group were all better than those in the control group (P<0. 05). The improvement of life quality in the observation group was more notable than that in the control group with statistical significance (P <0.05). Conclusion: Sodium cantharidate vitamin B6 injections can significantly in-crease the short-term curative effect and immune function, decrease bone marrow inhibition and improve life quality of advanced cervi-cal cancer patients.

Replacement therapy with plasma derived or recombinant F Ⅷ (rFⅧ) concentrates is only effective way to treat hemophilia A.Currently,the first,second and third generation rFⅧ are commercially available.Of the three products,the third generation rFⅧ products are best,because of no additional human or animal plasma proteins at any period.The use of rFⅧ concentrates has greatly improved the safety of replacement therapy in hemophilia A and reduced the risk of blood-borne pathogen transmission.In this article we review the current knowledge about the three rF Ⅷ concentrates,analyzing their main characteristic and their clinical hemostatic efficacy and safety.

Objective To investigate the effects of different tidal volume (V_T) on arterial oxygenation and intrapulmonary shunt(Q_S/Q_T) during one lung ventilation(OLV).Methods Sixty patients scheduled for selective lobectomy under left lateral decubitus position were randomly divided into groups of A,B and C with 20 cases each.After bronchial induction,two lung ventilation(TLV) was performed with V_T 10 ml/kg,frequency(f) 12 breaths per minute(BPM),ratio of inspiration to expiration(I: E) was 1:2 at first.During OLV,I: E was kept steady,V_T 6 ml/kg and f 20 BPM were chosed in group A,V_T8 ml/kg and f 15 BPM in group B,V_T 10ml/kg,f 12 BPM in group C.Blood gas analysis was determined before OLV (T_1) and at 10 min(T_2) ,20 min(T_3) ,and 30 min after OLV (T_4).Q_S/Q_T and lung complience(Cdyn) was calculated.Results OLV Compaired to T_1,PaO_2 and Cdyn were lower (P<0.05) and Q_S,Q_T and peak airway pression were increased (P<0.05).The decrease of PaO_2 was more in groups of A and C than that in group B(P<0.05).Conclusion During OLV,a better PaO_2.may be maintained with the ventilation parameters of V_T8 ml/kg and f 15 BPM with less increase in Q_S/Q_T and higher Cdyn.

The curriculum,as the core of school education,is the intermediary of turning educational thoughts,ideas,purposes and aims into concrete educational practice.Therefore,the key question of the reform of nursing education is the reform of its curriculum which should accord with the principles of sticking to humanism,stressing the characteristics of nursing speciality,strengthening the training objectives and paying attention to the fostering of the students qualities and abilities.

Objective To evaluate relationship and singnificance between metabolic syndrome (MS) and carotid atherosclerosis. Methods One hundred subjects were investigated,including 54 MS patients and 46 normal subjects.Body mass index,waist circumference,plasma lipid and fast glucose of all subjects were examined.Carotid intima-media thickness (IMT) was detected and plaque was scored with color Doppler ultrasound. Results The MS patients had significant higher carotid IMT,diameter,plaque index and plaque occurrence rate than those in normal ones. Conclusions The degree of carotid atherosclerosis in MS is much more severe than that in normal patients.The metabolic syndrome may promote the occurrence and the progress of atherosclerosis.Carotid ultrasonograohy may help diagnose coronary artery disease much earlier.

OBJECTIVE:To discuss the significance of prescription analysis in Chinese drugs dispensing and to probe into the profound connotation of the dispensing of prescriptions of traditional Chinese medicines.METHODS:Take the basic theory of Chinese medicine as the basis,the importance of prescription analysis in the dispensing of traditional Chinese medicines were analyzed from aspects of the patients' clinical diagnosis,medication intention as well as the function and properties of drugs etc.RESULTS:8 essential factors were found to be involved in prescription analysis,which shed new light on the omnidirectional pharmacy care provided for patients.CONCLUSION:The key for Chinese drugs dispensing lies in the prescription analysis.

OBJECTIVE:To prepare hydrocortisone lotion and establish its quality control method. METHODS: The lotion was prepared with hydrocortisone, and the content of hydrocortisone was determined by ultravidet spectrophotometry. The stability of the prepartion and its skin stimulus were investigated as well. RESULTS: The preparation was colorless limpid liquid and up to the standard specified in Chinese Pharmacopeia (2005 Edition) in the related test. The linear range of hydrocortisone was 5.0～30 ?g?mL-1(r=0.999 0) and the average recovery was 100.09% (RSD=0.17%). After storing for 3 and 6 months, respectively, no obvious change was noted for the preparation. The skin stimulus experiment showed that it caused no side effects such as erythema on skin or edema etc. CONCLUSION: This lotion is simple in preparing process, and its quality is stable and controllable.

Idiopathic thrombocytopenic purpura (ITP),as a heterogeneous autoimmune disease,is the most common bleeding disorder,of which etiology and pathogenesis are still unclear. Health related quality of life are severely affected,especally in chronic patients . Studys on chronic idiopathic thrombocytopenic purpura pathogenesis ,both in China and abroad,have found that genetic factors may be involved in the occurrence and prognosis of the disease. The paper gives a review from the follow aspects,such as its risk factors,relationship between genetic polymorphisms or expression levels and chronic ITP susceptibility and seriousness,the role of epigenetic,researchs about chronic and refractory ITP,et al.