1.Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies.
Jacquelyn W ZIMMERMAN ; Hugo JIMENEZ ; Michael J PENNISON ; Ivan BREZOVICH ; Desiree MORGAN ; Albert MUDRY ; Frederico P COSTA ; Alexandre BARBAULT ; Boris PASCHE
Chinese Journal of Cancer 2013;32(11):573-581
In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency (RF) electromagnetic fields (EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer.
Carcinoma, Hepatocellular
;
therapy
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Cell Proliferation
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radiation effects
;
Electromagnetic Fields
;
Humans
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Liver Neoplasms
;
therapy
;
Magnetic Field Therapy
;
adverse effects
;
Neoplasms
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diagnosis
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pathology
;
therapy
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Radiation Dosage
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Radio Waves
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Thyroid Neoplasms
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therapy
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Treatment Outcome
2.Surgical Management of a Type II Extracranial Internal Carotid Aneurysm near to the Skull Base
Miguel A. MENDEZ-SOSA ; Emmanuel CONTRERAS-JIMENEZ ; Javier E. ANAYA-AYALA ; Montserrat W. MIRANDA-RAMIREZ ; Gabriel LOPEZ-PENA ; Luis H. ARZOLA ; Santiago Mier y TERAN-ELLIS ; Hugo LAPARRA-ESCARENO ; Carlos A. HINOJOSA
Vascular Specialist International 2021;37(3):27-
True aneurysmal disease in the carotid arteries is very uncommon, but individuals with this pathology face the grave risk of thromboembolism, which may consequently lead to cerebrovascular accidents. Clinical knowledge remains relatively limited owing to its rarity. We present the case of a 41-year-old obese female with a type II right extracranial internal carotid artery aneurysm incidentally found during imaging work-up. She underwent open surgical reconstruction with an autologous interposition graft from the common carotid artery to the internal carotid artery at the base level of the skull. Her postoperative period was uneventful, and the patient was discharged on postoperative day five with aspirin. At 12 months of follow-up, the patient remained symptom-free without complications.
3.Surgical Management of a Type II Extracranial Internal Carotid Aneurysm near to the Skull Base
Miguel A. MENDEZ-SOSA ; Emmanuel CONTRERAS-JIMENEZ ; Javier E. ANAYA-AYALA ; Montserrat W. MIRANDA-RAMIREZ ; Gabriel LOPEZ-PENA ; Luis H. ARZOLA ; Santiago Mier y TERAN-ELLIS ; Hugo LAPARRA-ESCARENO ; Carlos A. HINOJOSA
Vascular Specialist International 2021;37(3):27-
True aneurysmal disease in the carotid arteries is very uncommon, but individuals with this pathology face the grave risk of thromboembolism, which may consequently lead to cerebrovascular accidents. Clinical knowledge remains relatively limited owing to its rarity. We present the case of a 41-year-old obese female with a type II right extracranial internal carotid artery aneurysm incidentally found during imaging work-up. She underwent open surgical reconstruction with an autologous interposition graft from the common carotid artery to the internal carotid artery at the base level of the skull. Her postoperative period was uneventful, and the patient was discharged on postoperative day five with aspirin. At 12 months of follow-up, the patient remained symptom-free without complications.