Objective:To assess the feasibility ,safety and short‐term outcome of simultaneous integrated boost‐intensity modulated radiation therapy(SIB‐IMRT) with concurrent capecitabine chemotherpay for anal cancer .Methods:A total of 10 hospitalized patients with anal cancer during Sep .2009 and Feb .2014 were treated with SIB‐IMRT .A total dosage of 57 .6 Gy was given to the primary lesion and macroscopical lymph nodes in 32 fractions ,with 1 .8 Gy in each fraction .And a total dosage of 48 Gy was given to the bilateral iliac vessels and inguinal lymphatic drainage region in 32 fractions ,with 1 .5 Gy in each fraction .And capecitabine was concurrently administered at the oral dose of 625 mg/m2 ,twice daily ,5 days per week . Two patients received a sequential radiation boost dose of 2 × 1 .8 Gy due to macroscopic residual lesion at week 5 of treatment . Acute and late adverse reaction was assessed according to the Common Terminology Criteria for Adverse Events version 4 .0 . Results:All patients completed radio‐chemotherapy without any treatment break .The incidence rate of grade 3 skin adverse reaction was 50% (5/10) .No grade 4 adverse reaction was observed .Mean follow‐up was 20 months(range 6‐60 months) .The 2‐year‐local control ,colostomy‐free survival ,distant metastases‐free survival and overall survival rates were 100% (10/10) ,90%(9/10) ,90% (9/10) ,and 90% (9/10) ,respectively .Conclusions:SIB‐IMRT with concurrent capecitabine chemotherapy :an acceptable safe regimen ,however ,more samples and a longer follow‐up are required to assess its potential superiority .

Objective To analyze the current status,research hotspots and development trends in the field of immune responses in the microenvironment after spinal cord injury(SCI). Methods Literatrues about immune responses in the microenvironment after SCI were searched from CNKI and the Web of Science Core Collection,from inception to March,2024.VOSviewer and CiteSpace were used to conduct a vi-sual analysis of authors,countries,institutions,journals,co-cited references and keywords. Results A total of 152 Chinese and 455 English studies were included.The number of publications increased annually,and China and the United States were leading research efforts in this field.In the Chinese literature,Zhu Yue was the most prolific author,and China Medical University was the leading institution.In the English literature,Phil-lip Popovich was the most prolific and highly cited author,and Ohio State University was the leading institution.Journal of Neuroscience and Experimental Neurology were identified as key journals.The research hotspots in both languages focused on immune activation,inflammatory response and functional recovery.Researches on stem cell transplantation,macrophage and traditional Chinese medicine were particularly prominent in the regu-lation of immune responses after SCI. Conclusion Immune responses in the microenvironment have emerged as a central focus in SCI research.The emphasis of current researches is shifting from mechanistic exploration to the investigation of immunomodulatory strate-gies,with several cutting-edge technologies showing significant potential in this regard.Moving forward,increas-ing collaboration across regions and institutions are essential to promote information sharing,accelerate scientific progress,and facilitate clinical translation,ultimately enhance patient rehabilitation outcomes.