Objective:To analyze and integrate the illness experience of female patients with systemic lupus erythematosus (SLE) .Methods:The qualitative studies on the illness experience in female SLE patients were searched in PubMed, Web of Science, CINAHL, the Cochrane Library, PsycINFO, China Biology Medicine disc, Wanfang Database, VIP, CNKI and other Chinese and English databases by computer. The retrieval period was from the database construction to April 30, 2021. The quality of the literature was evaluated using the Australian JBI Evidence-based Health Care Center (2017) Qualitative Research Quality Evaluation Standard, and the results were integrated and analyzed using the collection integration method.Results:A total of 9 literatures were included, which were classified into 13 categories and integrated into 4 integration results. First, the patients lacked disease knowledge, family and social support and they desired support. Second, the disease caused physical discomfort and impaired self-image to patients, and their daily life, work, and childbirth are restricted. Third, the disease brought a series of negative psychological experiences to patients. Fourth, patients learned to accept themselves and could actively adjust coping strategies.Conclusions:Over time, SLE patients can learn to accept themselves and coexist with the disease. It is recommended that medical staff give patients necessary guidance to help patients correctly understand the disease and provide individualized interventions to improve the quality of life of SLE patients.