1.Survey on the Research of Traditional Chinese Medicine Therapeutic Evaluation Information Processing Method in the Real Word
World Science and Technology-Modernization of Traditional Chinese Medicine 2018;20(4):592-596
In the process of current clinical efficacy evaluation of traditional Chinese medicine, there are four diagnostic information lack of scientific evidence, patients with individualized information using deficiencies. For example the inadequate efficacy evaluation is rarely mentioned in literature methodology to process syndrome. In order to deal with clinical information more objectively and comprehensively, The clinical curative effect of traditional Chinese medicine should be evaluated reasonably, so as to facilitate the clinical treatment of syndromes. This article describes the background, classifications, advantages and disadvantages of traditional Chinese medicine therapeutic evaluation information of processing method in the real word. Mainly introduced the classifications, include quantification and forecast. The former includes the scaling method, scaling method by TCM diagnosis instrument, Data Envelopment Analysis, Propensity score method, Fuzzy Mathematics Calculation Model and Prescription similarity model. The latter includes the multilevel statistical models, Generalized Linear Model and Markov model. In this paper, we introduce the common information processing methods in clinical practice, and the purpose is to simplify and clarify the evaluation objects so as to facilitate the evaluation of TCM clinical efficacy.
2.Repair of rabbit bone defect with composite of calcium phosphate bone cement and calcium phosphate cement mixed with different ratio of minimal morselized bone in vivo
Jiabin MA ; Lei ZHOU ; Jinglong YAN ; Guangping CHANG ; Huaxing PAN ; Chunyang XI ; Jianing ZU ; Ye JI ; Yanjing LI ; Zhihui GUAN
Chinese Journal of Trauma 2011;27(8):737-741
ObjectiveTo explore the effect of the calcium phosphate cement (CPC) /calcium polyphosphate fiber (CPPF) composites mixed with different proportion of minimal morselized bone on repair of bone defect in vivo. MethodsA total of 36 New Zealand white rabbits were completely randomly designed into A, B, C, D groups and their bilateral radial bone defect model was prepared. The minimal morselized bone (300-500 μm in diameter) was made from the iliac of those rats. The CPPF and CPC were evenly mixed into CPC/CPPF composites which were divided into four groups in accordance with the CPPF weight O, 10%, 30% and 50% in CPC/CPPF composite. The CPC/CPPF composites of the four groups was mixed with the minimal morselized bone with ratio of 6:4 and then the mixture was implanted the bone defect of the rabbits in four groups. The gross, X-ray and histological observations were done at four and eight weeks. The biomechanical test was performed at eight weeks. Results When CPPF occupies 30% of the CPC/CPPF composite, the maximum compressive load and bending loads were better than those in the other groups ( P < 0.05 ), when the histological observation showed the most tight link between the artificial composite and the bone interface and the closest similarity between material degradation rate and the ossification rate, with the best osteogenesis and the optimal ratio.ConclusionThe repair of bone defect can attain the optimal outcome through adding a certain ratio of minimal morselized bone into the CPC/CPPF to adjust the degradation rate of composites.