ObjectiveTo investigate the expression of adhesion molecules cyclooxygenase-2 (COX-2)and survivin protein in elderly patients with gastric cancer and their relationship with the pathological behavior and prognosis,MethodsImmunohistochemical staining was used to detect the expression of COX-2 and survivin protein in 60 cases of elderly patients with gastric carcinoma,30 cases of gastric epithelial dysplasia and 20 cases of normal gastric mucosa.The study was also combinedwith analysis of the pathological behavior and clinical follow-up survey of elderly patients with gastric carcinoma.ResultsThe positive expression rates of COX2 and survivin protein in elderly patients with gastric carcinoma were 63.3％(38/60) and 70.0％(42/60),respectively.The positive rates of COX-2 and survivin in elderly patients with gastric carcinoma were higher than that in epithelial dysplasia and normal gastric mucosa( P ＜0.05).The expression of COX-2 and survivin were closely related to the infiltration of serosa,metastasis of lymph node and prognosis of patients ( P ＜ 0.05 ).ConclusionThe expression of COX-2 and survivin are closely related to carcinogenesis,metastasis and survival time in elderly patients with gastric carcinoma.Detecting the expression of COX-2 and survivin may be prognostic indicators of elderly patients with gastric carcinoma.

Objective To investigate the expression of CA242 and CD_(44v6) protein in gastric cancer (GC) and its clinical significance. Methods Immunohistochemical staining was used to detect the expression of CA242 and CD_(44v6) protein in 120 cases of GC, 30 cases of gastric epithelial dysplasia and 20 cases of normal gastric mucosa. The pathological feature of GC and clinical follow-up data was also analysed. Results The positive rate of CA242 and CD_(44v6) was 79.2 % and 81.7 %, respectively in primary GC. The positive rate of CA242 and CD_(44v6) in GC was higher than that in epithelial dysplasia and normal gastric mucosa (P <0.05). The expression of CA242 and CD_(44v6) was closely related to infiltration of serosa, metastasis of lymph node and prognosis of patients (P <0.05). Conclusion These data suggest that the expression of CA242 and CD_(44v6)is closely related to carcinogenesis, metastasis and survival rate in GC. CA242 and CD_(44v6) may be prognostic indicators of GC.

Objective To investigate the expression of survivin and CD44v6 protein in gastric cancer(GC) and its clinical significance.Methods Immunohistochemical staining was used to detect the expression of survivin and CD44v6 protein in 120 cases of GC,30 cases of gastric epithelial dysplasia(GED) and 20 cases of normal gastric mucosa(NGM).The pathological features of GC and clinical follow-up data were also analyzed.Results The positive rate of survivin and CD44v6 was 75.8% and 81.7%,respectively,in primary GC.The positive rate of survivin and CD44v6 in GC was higher than that in GED and NGM(P

ObjectiveTo explore the correlation of expression of galetin-3 (Gal-3) and epidermal growth factor receptor (EGFR) with the biological behaviors in esophageal squamous carcinoma(ESC). MethodsImmunohistochemical method was used to examine the expression of Gal-3 and EGFR in 80 specimens of ESC. ResultsThe positive rates of Gal-3 and EGFR was 73.8％ (59/80)and 56. 3％ (45/80)respectively. The positive rates of Gal-3 and EGFR expression in the patients with poor differentiation, deep infiltration and lymph node metastasis was significantly higher than those with well differentiation, shallow infiltration and without lymph node metastasis ( P ＜ 0. 05 ). The high expression of Gal-3 and EGFR was correlated with higher percentage of death and lower survival rate ( P ＜ 0.05 ). ConclusionThe abnormal expression of Gal-3 and EGFR is closely related with the pathological biology behaviors of ESC. Gal-3 and EGFR can be regarded as objective indicators for forecasting metastasic potential of ESC and estimating prognosis of patients with ESC.

Objective To investigate the correlation between the expression of cyclooxygenase-2 (COX-2),vascular endothelial growth factor(VEGF) protein,and metastasis in human papillary thyroid carcinoma (PTC).Methods lmmunohistochemical method was used to detect the expression of COX-2 and VEGF protein in 66 cases of PTC,20 cases of thyroid adenoma (TA),20 cases of nodular goiter (NG) and 15 cases of adjacent noncancerous (AN) tissues.Results The positive expression rate of COX-2 (72.7％,48/66)and VEGF (59.1％,39/66) was significantly higher in PTC than in TA( 10.0％,15.0％ ),NG( 15.0％,20.0％ )and AN (0.0％,13.3％ ) (P ＜0.05).The expression of COX-2 and VEGF was closely related to invasion,metastasis,and survival duration of PTC patients (P ＜0.05).Conclusion The expression of COX-2 and VEGF is closely related to biological behaviors of PTC patients and can be taken as prognostic indicators for PTC patients.

Purpose:To investigate the relationship of expression of CD44v6, E cadherin (E Cad) with clinic biologicl behavior in breast cancer and its correlation. Methods:Catalyzed signal amplification immunohistochemical method was used to detect the expression of CD44v6 and E Cad in 94 cases of breast cancer.Results:The positive expression of CD44v6 and the negative expression of E Cad were positively correlated with the grading, clinical stage, lymph node metastasis recurrence and prognosis of breast cancer. In breast cancer, the expression of CD44v6 had negative correlation to that of E Cad.Conclusions:Several genes were involved in the occurrence and development of breast cancer in which the expression of CD44v6 had negative regulative synergistic action with that of E Cad. CD44v6 and E Cad expression, as a clinical valuable marker, has a great significance in assessing node metastasis and survival.

Objective:To investigate the relationship between the expression of CD 15 antigen and Cath-D carcinogenesis,progression and metastasis of endometral carcinoma.Methods:The expression of CD 15 and Cath-D in 40 cases of endometral adenocarcinoma was detected by SP immunohistochemical technique.Results:The positive rates of CD 15 and Cath-D were 72.5% and 67.5% respectively.CD 15 was correlated with the histologic grading and clinical staging of endometral adenocarcinoma (P

This study was conducted to study the expressions of sialyl Lewis X and P16 protein in colorectal carcinoma and their relationship with differentiation, metastasis and prognosis of colo rectal carcinoma. Sialyl Lewis X and P16 expressions were determined with microwave-LSAB immunohistochemical technique. The positive rates of sialyl Lewis X and P16 were 92.2% and 42.2% respectively. The increased expression of sialyl Lewis X and the weakened expression of P16 were significantly correlated with metastatic proclivity and poor prognosis of the malignancy. These findings indicated that combined examination of the expression of sialyl Lewis X and P16 might be useful in estimating the differentiation, infitrtion, metastasis of colo-rectal carcinoma and prognosis of the patients.\;

To investigate the relationship of expression of sialyl Lewis X (SLeX) antigen,CD44v6 and E cadherin(ED) with staging,infiltration,node metastasis and prognosis in breast cancer, immunohistochemical method was used to detect their expression in 94 cases of breast cancer.The positive expression of SLeX,CD44v6 and the negative expression of ED were positively correlated with the grading, clinical staging, lymph node metastasis recurrence and prognosis of breast cancer.The results demonstrated that the expression of SLeX, CD44v6 and ED as a clinical valuable marker,has a great significance in assessing node metastasis and prognosis.

Objective To investigate the relationship between the expression of tumor suppressor gene PTEN and p16 protein and the biologcal behaviors of cholangiocarcinomas.Methods The expression of PTEN and p16 protein in 43 of cholangiocarcinoma tissues and 10 chronic cholangitis tissues were investigated by immunohisto-chemical technique.The relationship between expression of PTEN and p16 protein and the clinicopathological parameters of cholangiocarcinoma was analyzed. Results The positive expression rate of PTEN and p16 protein in cholangiocarcinoma was 39.5% and 44.2%,respectively.The expression of PTEN and p16 protein were positively relatad with the TNM staging,differentiation degree and metastasis of cholangiocarcinoma (P